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Gene: Efcab8 (EF-hand calcium binding domain 8) Rattus norvegicus

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Symbol:

Efcab8

Name:

EF-hand calcium binding domain 8

RGD ID:

1597364

Description:

Predicted to enable calcium ion binding activity. Orthologous to human EFCAB8 (EF-hand calcium binding domain 8); INTERACTS WITH bisphenol A; methoxychlor; paraquat.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

EF-hand calcium-binding domain-containing protein 8; hypothetical protein LOC690324; LOC499923; LOC690324; RGD1560257; similar to hypothetical protein A630008I04

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	162,717,381 - 162,783,900 (+)	NCBI		GRCr8
mRatBN7.2	3	142,257,195 - 142,323,743 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	142,257,229 - 142,323,743 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	3	149,259,684 - 149,326,182 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	3	155,638,634 - 155,703,450 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	144,161,795 - 144,225,579 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	140,998,446 - 141,066,191 (+)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

glutathione synthetase deficiency (ISO)

glutatione synthetase deficiency with 5-oxoprolinuria (ISO)

immunodeficiency-centromeric instability-facial anomalies syndrome 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

genistein (ISO)

methoxychlor (EXP)

mono(2-ethylhexyl) phthalate (ISO)

paraquat (EXP)

permethrin (ISO)

quercetin (ISO)

resorcinol (ISO)

thiram (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Molecular Function

calcium ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Efcab8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	162,717,381 - 162,783,900 (+)	NCBI		GRCr8
mRatBN7.2	3	142,257,195 - 142,323,743 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	142,257,229 - 142,323,743 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	3	149,259,684 - 149,326,182 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	3	155,638,634 - 155,703,450 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	144,161,795 - 144,225,579 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	140,998,446 - 141,066,191 (+)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

EFCAB8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	32,858,923 - 32,961,845 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	32,858,923 - 32,961,845 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	31,446,729 - 31,549,651 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	30,908,661 - 31,013,076 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	20	28,200,602 - 28,303,292 (+)	NCBI		Celera
Cytogenetic Map	20	q11.21	NCBI
HuRef	20	28,253,776 - 28,268,367 (+)	NCBI		HuRef
CHM1_1	20	31,355,022 - 31,384,535 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	34,585,603 - 34,688,526 (+)	NCBI		T2T-CHM13v2.0

Efcab8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	153,615,231 - 153,686,672 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	153,621,851 - 153,686,671 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	153,773,311 - 153,844,752 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	153,779,931 - 153,844,751 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	153,606,615 - 153,620,918 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	153,606,615 - 153,620,918 (+)	NCBI		MGSCv36	mm8
Celera	2	159,625,729 - 159,640,086 (+)	NCBI		Celera
Cytogenetic Map	2	H1	NCBI

Efcab8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955422	28,269,996 - 28,337,345 (-)	NCBI	ChiLan1.0	ChiLan1.0

EFCAB8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	38,546,512 - 38,651,210 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	38,539,611 - 38,644,308 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	29,141,250 - 29,247,827 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	30,260,913 - 30,366,017 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	30,265,759 - 30,366,017 (+)	Ensembl	panpan1.1		panPan2

EFCAB8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	22,170,315 - 22,238,276 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	22,130,125 - 22,238,109 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	21,815,426 - 21,885,352 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	22,856,659 - 22,925,239 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	24	22,131,574 - 22,201,421 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	22,241,212 - 22,311,125 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	22,672,221 - 22,742,126 (+)	NCBI		UU_Cfam_GSD_1.0

Efcab8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	171,183,947 - 171,246,080 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936485	19,619,695 - 19,677,243 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EFCAB8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	36,431,992 - 36,487,494 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	36,432,415 - 36,487,513 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	41,369,399 - 41,424,431 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EFCAB8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	37,238,115 - 37,287,583 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666050	89,574,988 - 89,666,892 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Efcab8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624842	6,321,306 - 6,391,517 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Efcab8
279 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	112
Count of miRNA genes:	94
Interacting mature miRNAs:	101
Transcripts:	ENSRNOT00000038684
Prediction methods:	Microtar, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
1598877	Bp285	Blood pressure QTL 285	1.5	0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	120538241	165538241	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141074471	169034231	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	137398739	169034231	Rat
61335	Bp20	Blood pressure QTL 20	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141339236	155617360	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141339013	162184794	Rat
1300173	Rf11	Renal function QTL 11	3.38		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	121056165	145956249	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	122438700	167438700	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	127162703	168026850	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	118839124	163839124	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	121056165	157309487	Rat
5686842	Rf59	Renal function QTL 59			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	3	140069424	146976080	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	130193298	161695983	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	138799500	169034231	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001430734	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001430735	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001430736	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762400	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762401	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762402	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775585	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775586	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775587	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285087	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285091	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285094	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000108968 ⟹ ENSRNOP00000097645

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	142,257,229 - 142,323,743 (+)	Ensembl

RefSeq Acc Id:

XM_008762400 ⟹ XP_008760622

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	162,717,383 - 162,783,900 (+)	NCBI
mRatBN7.2	3	142,257,203 - 142,323,743 (+)	NCBI
Rnor_6.0	3	149,259,685 - 149,326,182 (+)	NCBI

Sequence:

show sequence

GTGGCCGCCGCGTGCGGAGCAGTTTTCCTCCAGCCTCAATCCCAGCGCCGCTCCTACCCACGCG
CACATTTGTCCTTCCTGGACAAGGTTAACGCCTCGTCTCGCACAGCTGTGCCTCCTGAGCCCCT
CCCTTGGAGACATTGTTCTCTGTGGACCCCCTTGCTTCTGCTCTGCAGAGCGCCCCCTGTTCCT
AAAAGGGCTCTAAACCGTATCCAGTTCTTAAAAGTGTTCACGCTTAGACGTCAACCACTCCTGC
AGCTACTAGAATCAAACATTCATCGTCAACAGTCGGGTTCTGCCGGCACTCCCTTCCTCAAGGG
CAAGACTAATGTCTTCTGAGGAGTCAGGAGAGAGCCCTCAATCCCAAAAGATGGCCCAACCAGG
TGGAGTCCAGGAGGAGACTTCTAAGACCTATCCAGTGACAAGTTCCGTCAGCCAGAGCAGTGAA
ATCCATCAAAGCACTCAGCAGTTTACCGAGATGCACCTGGCTGACCTACAGAAGGTGTTTGAGA
AGGAGGCAGACGAGAACGGAGCCCTGAAAAAGGAAGGCTTCATCAAGGTCATGAAGTGGGTACT
GAGTAACATGTCGGAGGAGATGCTCGAGGTGCTGTTCTTGAAGGTGGACTCAGACTGCAATGGC
TTTGTCACCTGGCAGAAGTATGTGGATTATATGATGCGTGAGTTCCAGGGCAAGGAGGAGATGA
GGAAGAGCCAATACCGCCTGCGCTTCCACCTTCCCATGACCGTCATCCCCCTGCACCATGGGAG
CGAGGTTGTGAAAGTGGCGTTTTTAACCCAAGGGTTCAAAAAGATAGGCTGTTTCCTGACTGTC
ACCAAAGATGGGATCCTGCAGTTCTGGTCTGAGACCTTCTCAATGATGGATTCTTTCCGGCTTA
CTCAGACCAAGCAGTTTGGCCACCAGCAGATGTGGGTTGTCGACGTGGCATATCTGCACAACAT
GAACCTCATCGCTGTTGCCTCGACTGAGCTGAAGATAGAGTTCTTTGATATCAGTGGCTACAAA
TGCATCCGGGCCTTCACCTTTATTGATCTAGATAGCTGTGCCATGGCCATGCACTATTGGACTG
ACTATCACAAGGCTGTGTTCTGCTTTGGGGACACCAAGGGCAATGTCGTCATCTTCATCTCGGA
CAACGTGGTTGGTGGGCTGTTCAACCCACAAATCCTCCCCCGGACCTCCAAATGGGATCACTGG
ATCCCTGTCTCCTTGAGGAGGCTCTTGAACAAGAAGTCCCCTCTGTATAGAAGTTTCCGAATGA
AGGGTCTCCACCCCAACTGGTGTCAGCAGATCAAGTACATCCCGCAGTTGAATGTAGTGGTCTC
GTGTTCAGCCGTTGAGAAGTCCTCTCTGGTGCTGATAATACTGCCGCCCAAAGATCCCGAGAGA
CCCAAGTTATCATCACTGAGTTTAAGAAAAGGAATTCTTTGCTTTGACTACTGTCCGGACCGGA
ACTTTCTGGCAACTGGCGGCTATGACCCCCACATCCGCCTGTGGAACCCCCTGGTCTCAAAAAG
GCCCGTGTGGCTGATGAAGGGACATCAGACATCAGTGACACACCTCCTTGTGAGCAGCAAGAAC
GCCAGCATCCTGATCAGCATTTCCAGGGACAAGAACGTTCGAGTGTGGGATCTGCAGGACTATG
TATGCCTCCAGTCTTTCTGCGGGAAGCTTTTCCCCCTGGGCAACTGCCCCATAACCAGCGCCTA
CTTCCACAGAAGCAGCACGCTCATCTGCAGCACCTACAATATTGGGATCCTCAGAGGGTACTTG
GAATCCCAGGGGCCCCTGAAAACAGGGAGGATAACGACTCACAACACACCGGTGTGCACCATCC
TCTACAGCAAGATCTTCAAGCAGGTGGTTAGCGGTTGCCTCCAGGGCATCGTGAGTGTGTGGGA
CATCAGCACAGGCAAGAAGAGGATGGAGTTACCCGTGTCCGGCATCCAGGAAAGCGAGCTGACG
GCCATGTCTCTGGACGAGTCGGAGAGGTGTCTGCTCACAGGCTTGCGTGACGGCACGGTGCAGA
TGTGGAATTACAACACTGGGGAGTGCCTGCTGACCTTTCCCAACCCGGACAAAGTGGAGATTAG
TGGAATAGTCCACATGAACAAAGTGTACTACATGACCGGGTGGAGTAAGAGAATCACCAATTTC
ACGTTCCAAAAGGCCACACAGACATTCTCCTGCTACCACTGGCAAAGCTTCCACACAGAGGACA
TCCTGAGCATGGACAAGTATCAGAACCAGTTCCTTGGGACCTCTTCCTACAATGGGGACATTGT
TTTCTGGAATGTCAGCACGATGAAGCCTATCTTGAGTTTCAATGCCTCCAAGAGTCCCTTGCCT
TTACAGCCAAAGAAGGTGAGAGAAACGGAGACATGTGCACCCAAATCTCCAGCCCATCTAGACT
TTGAAGTTCAAAAGTGGGCACACAAGCCCTGGAAGTCAACTGCCTCCACTGTGAAGCGAAGACT
GATGTCAGCTCCCCCAGTGATGAAACACTGGAAGGATACAGAGCAAGAGAGGAATGTGGCGCAG
GAGAAACATTTCAGGAGTAACAAACCTGGATTGTCTAAAATGCTCTTTGATAAGTCGACCCATA
AACCACCGTTTTACAAAGACGCTCAAATGAGAAAGGGGGAGTTCTGGCAGAAGATGCTGCTGCA
GTCCAGCGTGTCAGTGGAGAAGATCATTTTTCTGCAGACCAGGCCCCGCCTGCCGCACACGGCT
GCCCTGCTGAGCAGCTGCATCGATGGCTTCATCTACGCCTGGTCCATCCATGGGAACGGGGGTC
TGCTGGGAAAGTTCTCTGTGGACCCCAAAGACACTGGGTGTGTCGTGGGTGCCATGGCCACTGA
TGAAAACAACTGGATCCTCCTCACCGGGGACAGTAAAGGAAATATCAAGATCTGGGACATCAAG
GATTACTGCTGCTTTATTGGCCAGCAACCATTCCACTCCAGTGGGAGCTCGATCTCTGGTGACA
CGGAGAATAAGTTCCGGCTCTTGATTCCTAAAGAACTCCAGATCTACTCTCAGCACCACTTGCT
ACAGAAGGAGAAGGAGGTTGTGGAAGGACAGACCATTTCTCTGGTTCCCCCACCACTTCTGATT
ACCTGGAATAGCCACATGGACAGCGTGACAGACATCCTGTATGTGGACTCCTTCCGGCTAGTTG
TCAGTGCGAGCGAGGATCGGGACGTCAAGGCTTGGAAATTCTTTGGTGAAATGATAGGAACATT
TGGCCTGGGTCTTTGGAACAGACTACAGGAGGCTGCGGTGACCGACAAGCTGGAGCAGGCCGAA
AGTTTGGAGAAGAAACCCGACTTCACTGGTGCTGCCCTCAAGCACTCCTTCCTAGAGCTGGACA
AGGAACTGGCTGAAGCTCTGGTGTACCAGCGGCGTGAGCAAGCAGCACTCATGGCCCTCCTGCA
CGGGAAAGCTGAGAAAGAAACTGAGGCATGGTACAGGCTGCAGCAGATGTCCCTGTTATCCCCG
TGGTCCAAAGATTCTTCTATGGAAGACATTGAGGAGAGCTGGAATCGATGGGCCAAGGACAAGC
AGGCAAGCAAAATTGTGGGAGCAGCATATAAGCCCAAGTTGCGTGTTCGGAACCCCAAACTCCT
GACCTCCAGAGCGCAGTTTAACTGGATGAGGCAGCAGATCTCTCCTCAGATCTACCAATGCCTA
TCCTTTACTGACCTTAAGCCAGTCCAACAGCCTGACTTCCTGATGCATAAGATCCTGGACCAAG
AAGGACGGCACATTCGCTGGGTGGCCAGTGATAACCGGAGTGAGCTGGAGTTTTTCCGGGGTCA
GATCTTCACAGACATCACCTCACCTGCCACCCACTCTTCCCTCTCCACTCTTTCTGTGGGGCCA
TCGGCCTCCAACTGGTCTACCTCCCTGAAGCCCCATTCATCTGGTTCCTTCGTGAGGCCTTCAT
CAGCCTCTCCAGTCCATTCTAGCTCTTCTACATCACCACAGCAGACCTCGGGTCTGCTCCGCAG
AGGTCAGAGACCCCAAGGCCAATTGTTATCTCCTTCTTGCAGTATCCGAATCCCAGGGGAGCCA
CCCTCATGTCCTCTGTGAAGTGGGGCTTCCACCTCATGTATTGAGGTGTTCGTTTTTCTCTCTG
TTCTGAAGCAGGGGACCTATAGGGTCTTGCACGTCCCTGGCTCACTCCCTGCCAGGCCTGGAGG
ATGCAGCCCTTTCCTCCCATACTGCTTCTGTCTGGATAATTCCAGCTGTCTTGTGGCTCTGCAC
AATTCTGGAGAAGAAAAGAAAATAAATATTCTCCTGCATTAGAGTTCTACAGGTGACATGGCCG
TGCTATGTCTTTCACACTCTTAGGTCCCTGCTATGCTATGGGACAGGTCACAATGCCTGGAAAG
GCCTTAAGCAGACAGTGAGAGTCCTATGCCTCAGGATTCCTGGGTGCTTTGCCTACCGTGCAGC
AGGCCCACCCCACTAGGGCTCTGGGTGGCATTGCAGATCACATGGTTGGGATGCCCGATAGTTC
AGCAGCCTGATTCAGCCTCACAGAAGTCATTCTGTGCTGAGTGTCTGCTTGTCCTTTGTCCCTG
ATGTCTGTCTTCCTTGGCCATCAGCCCCAGCTGCAGTGTCTGGAAGCTGCTCTGTGCCTCATAT
CAATGATATCTGAGTATGTAAACAGGCGGTTCCTACTGTGGATCTGAAACATCCTTCTTGGCCG
GAAGCACCTGTCCCAAGCTCTGCCCGGTCTGTCCCTTTCAGAAGGCTAACTCTGGGCCATATAT
AAAATCCTAGACACAGAAGATTCCATTCAAAGGCCGTGAAGGATGGGGTCCCACCAACTCGAAT
GGGAGCCCTTTTGGGAACACGGCCTGTGGCTCTGGGCAGAGCAGATTCATCAGAGCGCATCCTT
GCTAGGGATGTGATACCAGGTCACCTCCCAGCAGCTCCAAAAACATCAGGTCTAGCAGAGCTGA
GGCCTTCTTTGGAGCCCACCAGAGGCAGTGGGCTCGAGGCTCAGCCGTAGCACAGGAGGGAAGG
GTCAAAGGAACTGGAACATCTTCGGCCTTGGGGTTTGAGCTGGGTCTCCACAACCCACAGGGCT
GGAGGACTGAGGTCCCCAAGCTCCTCACAGAGGGCCCCTTTATGTACATTTAACTTTTTATGTG
TGTGTGTGTGTTGTATACATGTGTGTGTTCTCATGTATGTAGGCACACATATGTGTGCCAGTGC
TTGTTCATGCATGCATGAGCATATGCAGGCCCAAGGTTGATGTGAGGTGTTTTCCTTCCTTTAG
ATAGAGACAAGGTTGCTCACTGATCCCAGAGTTCACTGACCTATGGGTCTTGAGCATCCGAACC
TTAGCCCCCATGCTTGCACGGCAAGTGTTTTACCCACCAGAGTTCTCTAGACCCTGTTCTTAAC
CTTTCTAGTGCTGCAACCCTTTA

hide sequence

RefSeq Acc Id:

XM_063285087 ⟹ XP_063141157

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	162,726,190 - 162,783,900 (+)	NCBI

RefSeq Acc Id:

XM_063285089 ⟹ XP_063141159

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	162,727,844 - 162,783,900 (+)	NCBI

RefSeq Acc Id:

XM_063285090 ⟹ XP_063141160

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	162,727,849 - 162,783,900 (+)	NCBI

RefSeq Acc Id:

XM_063285091 ⟹ XP_063141161

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	162,717,381 - 162,783,390 (+)	NCBI

RefSeq Acc Id:

XM_063285092 ⟹ XP_063141162

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	162,717,381 - 162,782,243 (+)	NCBI

RefSeq Acc Id:

XM_063285093 ⟹ XP_063141163

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	162,717,381 - 162,782,460 (+)	NCBI

RefSeq Acc Id:

XM_063285094 ⟹ XP_063141164

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	162,752,400 - 162,783,900 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001417663	(Get FASTA)	NCBI Sequence Viewer
	NP_001417664	(Get FASTA)	NCBI Sequence Viewer
	NP_001417665	(Get FASTA)	NCBI Sequence Viewer
	XP_008760622	(Get FASTA)	NCBI Sequence Viewer
	XP_063141157	(Get FASTA)	NCBI Sequence Viewer
	XP_063141159	(Get FASTA)	NCBI Sequence Viewer
	XP_063141160	(Get FASTA)	NCBI Sequence Viewer
	XP_063141161	(Get FASTA)	NCBI Sequence Viewer
	XP_063141162	(Get FASTA)	NCBI Sequence Viewer
	XP_063141163	(Get FASTA)	NCBI Sequence Viewer
	XP_063141164	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL85989	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000097645
	ENSRNOP00000097645.1

RefSeq Acc Id:

XP_008760622 ⟸ XM_008762400

- Peptide Label:

isoform X1

- Sequence:

show sequence

MSSEESGESPQSQKMAQPGGVQEETSKTYPVTSSVSQSSEIHQSTQQFTEMHLADLQKVFEKEA
DENGALKKEGFIKVMKWVLSNMSEEMLEVLFLKVDSDCNGFVTWQKYVDYMMREFQGKEEMRKS
QYRLRFHLPMTVIPLHHGSEVVKVAFLTQGFKKIGCFLTVTKDGILQFWSETFSMMDSFRLTQT
KQFGHQQMWVVDVAYLHNMNLIAVASTELKIEFFDISGYKCIRAFTFIDLDSCAMAMHYWTDYH
KAVFCFGDTKGNVVIFISDNVVGGLFNPQILPRTSKWDHWIPVSLRRLLNKKSPLYRSFRMKGL
HPNWCQQIKYIPQLNVVVSCSAVEKSSLVLIILPPKDPERPKLSSLSLRKGILCFDYCPDRNFL
ATGGYDPHIRLWNPLVSKRPVWLMKGHQTSVTHLLVSSKNASILISISRDKNVRVWDLQDYVCL
QSFCGKLFPLGNCPITSAYFHRSSTLICSTYNIGILRGYLESQGPLKTGRITTHNTPVCTILYS
KIFKQVVSGCLQGIVSVWDISTGKKRMELPVSGIQESELTAMSLDESERCLLTGLRDGTVQMWN
YNTGECLLTFPNPDKVEISGIVHMNKVYYMTGWSKRITNFTFQKATQTFSCYHWQSFHTEDILS
MDKYQNQFLGTSSYNGDIVFWNVSTMKPILSFNASKSPLPLQPKKVRETETCAPKSPAHLDFEV
QKWAHKPWKSTASTVKRRLMSAPPVMKHWKDTEQERNVAQEKHFRSNKPGLSKMLFDKSTHKPP
FYKDAQMRKGEFWQKMLLQSSVSVEKIIFLQTRPRLPHTAALLSSCIDGFIYAWSIHGNGGLLG
KFSVDPKDTGCVVGAMATDENNWILLTGDSKGNIKIWDIKDYCCFIGQQPFHSSGSSISGDTEN
KFRLLIPKELQIYSQHHLLQKEKEVVEGQTISLVPPPLLITWNSHMDSVTDILYVDSFRLVVSA
SEDRDVKAWKFFGEMIGTFGLGLWNRLQEAAVTDKLEQAESLEKKPDFTGAALKHSFLELDKEL
AEALVYQRREQAALMALLHGKAEKETEAWYRLQQMSLLSPWSKDSSMEDIEESWNRWAKDKQAS
KIVGAAYKPKLRVRNPKLLTSRAQFNWMRQQISPQIYQCLSFTDLKPVQQPDFLMHKILDQEGR
HIRWVASDNRSELEFFRGQIFTDITSPATHSSLSTLSVGPSASNWSTSLKPHSSGSFVRPSSAS
PVHSSSSTSPQQTSGLLRRGQRPQGQLLSPSCSIRIPGEPPSCPL

hide sequence

Ensembl Acc Id:

ENSRNOP00000097645 ⟸ ENSRNOT00000108968

RefSeq Acc Id:	XP_063141161 ⟸ XM_063285091
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_063141163 ⟸ XM_063285093
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_063141162 ⟸ XM_063285092
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_063141157 ⟸ XM_063285087
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063141159 ⟸ XM_063285089
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063141160 ⟸ XM_063285090
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063141164 ⟸ XM_063285094
- Peptide Label:	isoform X7

Protein Domains

EF-hand

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1597364	AgrOrtholog
BioCyc Gene	G2FUF-47204	BioCyc
Ensembl Genes	ENSRNOG00000070431	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000108968	ENTREZGENE
	ENSRNOT00000108968.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
	EF-hand	UniProtKB/TrEMBL
InterPro	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
	WD-EF-hand_domain	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:499923	UniProtKB/TrEMBL
NCBI Gene	Efcab8	ENTREZGENE
PANTHER	WD REPEAT-CONTAINING PROTEIN ON Y CHROMOSOME	UniProtKB/TrEMBL
	WD40 REPEAT DOMAIN 95	UniProtKB/TrEMBL
Pfam	WD40	UniProtKB/TrEMBL
PhenoGen	Efcab8	PhenoGen
PROSITE	EF_HAND_2	UniProtKB/TrEMBL
	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000070431	RatGTEx
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	Putative isomerase YbhE	UniProtKB/TrEMBL
	SSF47473	UniProtKB/TrEMBL
	SSF50978	UniProtKB/TrEMBL
UniProt	A0A8I6AS75	ENTREZGENE, UniProtKB/TrEMBL
	A6KHW6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-06-02	Efcab8	EF-hand calcium binding domain 8	Efcab8	EF-hand calcium binding domain 8	Data merged from RGD:149736310	737654	PROVISIONAL
2021-08-09	Efcab8	EF-hand calcium binding domain 8			Symbol and Name status set to provisional	45752	PROVISIONAL
2011-05-26	Efcab8	EF-hand calcium binding domain 8	RGD1560257	similar to hypothetical protein A630008I04	Data merged from RGD:1560257	737654	APPROVED
2010-04-23	Efcab8	EF-hand calcium binding domain 8	LOC690324	hypothetical protein LOC690324	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1560257	similar to hypothetical protein A630008I04	RGD1560257_predicted	similar to hypothetical protein A630008I04 (predicted)	'predicted' is removed	2292626	APPROVED
2008-01-09	LOC690324	hypothetical protein LOC690324	LOC682892	hypothetical protein LOC682892	Data merged from RGD:1593957	1643240	APPROVED
2006-11-20	LOC690324	hypothetical protein LOC690324			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-20	LOC682892	hypothetical protein LOC682892			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-03-07	RGD1560257_predicted	similar to hypothetical protein A630008I04 (predicted)	LOC499923	similar to hypothetical protein A630008I04	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC499923	similar to hypothetical protein A630008I04			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar