Gzmfl1 (Granzyme F like 1) - Rat Genome Database

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Pathways
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Gene: Gzmfl1 (Granzyme F like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Gzmfl1 (Ensembl: LOC691670)
Name: Granzyme F like 1 (Ensembl:similar to natural killer cell protease 7)
RGD ID: 1597224
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in killing of cells of another organism and proteolysis. Predicted to be located in cytolytic granule. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Orthologous to several human genes including GZMB (granzyme B).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC691670; LOC691670; similar to natural killer cell protease 7; uncharacterized protein LOC691670
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,956,223 - 33,959,163 (-)NCBIGRCr8
mRatBN7.21529,986,103 - 29,988,926 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,986,103 - 29,988,926 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1531,832,084 - 31,834,907 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,979,287 - 32,982,110 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01531,237,417 - 31,240,240 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01535,163,014 - 35,166,264 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1535,163,388 - 35,166,211 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01539,050,228 - 39,060,313 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41534,674,444 - 34,677,267 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1529,560,259 - 29,563,082 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19946888  


Genomics

Variants

.
Variants in Gzmfl1
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:35
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000059662
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 3 3 11 2 3
Below cutoff 4 22 14 8 14 1 4 10 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000059662   ⟹   ENSRNOP00000056414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,986,103 - 29,988,926 (-)Ensembl
Rnor_6.0 Ensembl1535,163,388 - 35,166,211 (-)Ensembl
RefSeq Acc Id: NM_001109646   ⟹   NP_001103116
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,956,340 - 33,959,163 (-)NCBI
mRatBN7.21529,986,103 - 29,988,926 (-)NCBI
Rnor_6.01535,163,388 - 35,166,211 (-)NCBI
Rnor_5.01539,050,228 - 39,060,313 (-)NCBI
RGSC_v3.41534,674,444 - 34,677,267 (-)RGD
Celera1529,560,259 - 29,563,082 (-)RGD
Sequence:
RefSeq Acc Id: XM_063274671   ⟹   XP_063130741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,956,223 - 33,959,163 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001103116 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130741 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM14318 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000056414
  ENSRNOP00000056414.2
Reference Protein Sequences
RefSeq Acc Id: NP_001103116   ⟸   NM_001109646
- Peptide Label: precursor
- UniProtKB: D3ZY93 (UniProtKB/TrEMBL),   A6KH89 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000056414   ⟸   ENSRNOT00000059662
RefSeq Acc Id: XP_063130741   ⟸   XM_063274671
- Peptide Label: isoform X1
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZY93-F1-model_v2 AlphaFold D3ZY93 1-248 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699705
Promoter ID:EPDNEW_R10229
Type:single initiation site
Name:LOC691670_1
Description:similar to natural killer cell protease 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01535,166,281 - 35,166,341EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597224 AgrOrtholog
BioCyc Gene G2FUF-13659 BioCyc
Ensembl Genes ENSRNOG00000049919 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059662 ENTREZGENE
  ENSRNOT00000059662.3 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:691670 UniProtKB/TrEMBL
NCBI Gene 691670 ENTREZGENE
PANTHER GRANZYME H UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Gzmfl1 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049919 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt A6KH89 ENTREZGENE, UniProtKB/TrEMBL
  D3ZY93 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Gzmfl1  Granzyme F like 1  LOC691670  similar to natural killer cell protease 7  Symbol and Name Changed 1299863 APPROVED
2008-01-09 LOC691670  similar to natural killer cell protease 7  LOC681857  similar to natural killer cell protease 7  Data merged from RGD:1590505 1643240 APPROVED
2006-11-20 LOC691670  similar to natural killer cell protease 7      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC681857  similar to natural killer cell protease 7      Symbol and Name status set to provisional 70820 PROVISIONAL