Plppr2 (phospholipid phosphatase related 2) - Rat Genome Database

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Gene: Plppr2 (phospholipid phosphatase related 2) Rattus norvegicus
Analyze
Symbol: Plppr2
Name: phospholipid phosphatase related 2
RGD ID: 1597171
Description: Predicted to enable lipid phosphatase activity and phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human PLPPR2 (phospholipid phosphatase related 2); INTERACTS WITH (-)-epigallocatechin 3-gallate; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lipid phosphate phosphatase-related protein type 2; Lppr2; phospholipid phosphatase-related protein type 2; plasticity related protein 4; plasticity-related gene 4; Prg-4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2820,467,071 - 20,479,474 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,467,071 - 20,479,474 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx824,497,880 - 24,510,469 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0822,793,436 - 22,806,016 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0820,696,681 - 20,709,077 (+)NCBIRnor_WKY
Rnor_6.0822,946,787 - 22,959,554 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,947,152 - 22,959,554 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0823,001,604 - 23,014,338 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4821,040,658 - 21,050,517 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera821,858,304 - 21,870,682 (+)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14750979   PMID:25943107  


Genomics

Comparative Map Data
Plppr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2820,467,071 - 20,479,474 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,467,071 - 20,479,474 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx824,497,880 - 24,510,469 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0822,793,436 - 22,806,016 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0820,696,681 - 20,709,077 (+)NCBIRnor_WKY
Rnor_6.0822,946,787 - 22,959,554 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,947,152 - 22,959,554 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0823,001,604 - 23,014,338 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4821,040,658 - 21,050,517 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera821,858,304 - 21,870,682 (+)NCBICelera
Cytogenetic Map8q13NCBI
PLPPR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,355,432 - 11,365,698 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1911,355,386 - 11,365,698 (+)EnsemblGRCh38hg38GRCh38
GRCh371911,466,108 - 11,476,374 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,327,109 - 11,337,372 (+)NCBINCBI36Build 36hg18NCBI36
Celera1911,360,936 - 11,371,242 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1911,042,113 - 11,052,420 (+)NCBIHuRef
CHM1_11911,467,084 - 11,477,386 (+)NCBICHM1_1
T2T-CHM13v2.01911,482,410 - 11,492,670 (+)NCBIT2T-CHM13v2.0
Plppr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,846,980 - 21,860,203 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,848,329 - 21,860,203 (+)EnsemblGRCm39 Ensembl
GRCm38921,935,684 - 21,948,907 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,937,033 - 21,948,907 (+)EnsemblGRCm38mm10GRCm38
MGSCv37921,742,718 - 21,753,351 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36921,688,676 - 21,699,309 (+)NCBIMGSCv36mm8
Celera919,207,511 - 19,218,335 (+)NCBICelera
Cytogenetic Map9A3NCBI
Plppr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,269,769 - 2,279,910 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554952,270,323 - 2,279,688 (+)NCBIChiLan1.0ChiLan1.0
PLPPR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11911,614,293 - 11,624,017 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1911,614,294 - 11,624,017 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01910,902,739 - 10,913,270 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PLPPR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,955,538 - 49,964,207 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,955,566 - 49,964,416 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,829,066 - 49,837,707 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02050,476,257 - 50,484,918 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2050,476,259 - 50,491,106 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,686,478 - 49,695,212 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,112,923 - 50,121,586 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,355,872 - 50,364,535 (-)NCBIUU_Cfam_GSD_1.0
Plppr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,895,903 - 208,904,817 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,450,338 - 1,459,106 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366591,450,314 - 1,458,800 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLPPR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl270,047,788 - 70,055,778 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1270,047,637 - 70,061,904 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2270,410,308 - 70,418,868 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLPPR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,289,234 - 10,300,511 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl610,289,695 - 10,300,920 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660749,593,413 - 9,604,350 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plppr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,158,726 - 3,168,030 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248283,159,313 - 3,168,030 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Plppr2
47 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:85
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000016790
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 2 74 10 29
Low 3 34 40 31 10 31 1 20 12 11
Below cutoff 9 15 8 9 8 7 9 5 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016790   ⟹   ENSRNOP00000016790
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl820,467,071 - 20,479,474 (+)Ensembl
Rnor_6.0 Ensembl822,947,152 - 22,959,554 (+)Ensembl
RefSeq Acc Id: NM_001005881   ⟹   NP_001005881
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2820,467,071 - 20,479,474 (+)NCBI
Rnor_6.0822,947,152 - 22,959,554 (+)NCBI
Rnor_5.0823,001,604 - 23,014,338 (+)NCBI
RGSC_v3.4821,040,658 - 21,050,517 (+)RGD
Celera821,858,304 - 21,870,682 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242628   ⟹   XP_006242690
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2820,468,669 - 20,479,474 (+)NCBI
Rnor_6.0822,946,789 - 22,959,554 (+)NCBI
Rnor_5.0823,001,604 - 23,014,338 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001005881 (Get FASTA)   NCBI Sequence Viewer  
  XP_006242690 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL78253 (Get FASTA)   NCBI Sequence Viewer  
  EDL78254 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001005881   ⟸   NM_001005881
- UniProtKB: F1LR33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242690   ⟸   XM_006242628
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000016790   ⟸   ENSRNOT00000016790
Protein Domains
acidPPc

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6W5G4-F1-model_v2 AlphaFold Q6W5G4 1-343 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695794
Promoter ID:EPDNEW_R6319
Type:initiation region
Name:Plppr2_1
Description:phospholipid phosphatase related 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0822,947,439 - 22,947,499EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597171 AgrOrtholog
BioCyc Gene G2FUF-31401 BioCyc
Ensembl Genes ENSRNOG00000012164 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000016790 ENTREZGENE
  ENSRNOP00000016790.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016790 ENTREZGENE
  ENSRNOT00000016790.7 UniProtKB/TrEMBL
InterPro LPPR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_Acid_Pase_2/haloperoxi_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_Acid_Pase_2/haloperoxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:300443 UniProtKB/TrEMBL
NCBI Gene 300443 ENTREZGENE
PANTHER PTHR10165 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10165:SF15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PAP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plppr2 PhenoGen
SMART acidPPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48317 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1LR33 ENTREZGENE, UniProtKB/TrEMBL
  PLPR2_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-10-26 Plppr2  phospholipid phosphatase related 2  Lppr2  lipid phosphate phosphatase-related protein type 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-14 Lppr2  lipid phosphate phosphatase-related protein type 2  Prg-4  plasticity-related gene 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-23 Prg-4  plasticity-related gene 4  Lppr2  lipid phosphate phosphatase-related protein type 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Lppr2  lipid phosphate phosphatase-related protein type 2  PRG-4  plasticity related protein 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 PRG-4  plasticity related protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL