Tmprss11a (transmembrane serine protease 11A) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Tmprss11a (transmembrane serine protease 11A) Rattus norvegicus
Analyze
Symbol: Tmprss11a
Name: transmembrane serine protease 11A
RGD ID: 1596322
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region and membrane. Orthologous to human TMPRSS11A (transmembrane serine protease 11A); INTERACTS WITH bisphenol A; N,N-diethyl-m-toluamide; permethrin.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC686581; similar to transmembrane protease, serine 11A; transmembrane protease serine 11A; transmembrane protease, serine 11A
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21421,624,881 - 21,665,284 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1421,606,547 - 21,665,279 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01423,226,735 - 23,284,515 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1423,245,653 - 23,283,092 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01423,136,021 - 23,173,398 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1421,079,097 - 21,138,292 (+)NCBICelera
Cytogenetic Map14p21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Tmprss11a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21421,624,881 - 21,665,284 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1421,606,547 - 21,665,279 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01423,226,735 - 23,284,515 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1423,245,653 - 23,283,092 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01423,136,021 - 23,173,398 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1421,079,097 - 21,138,292 (+)NCBICelera
Cytogenetic Map14p21NCBI
TMPRSS11A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38467,909,395 - 67,963,493 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl467,909,395 - 67,964,140 (-)EnsemblGRCh38hg38GRCh38
GRCh37468,775,113 - 68,829,211 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36468,458,614 - 68,511,827 (-)NCBINCBI36Build 36hg18NCBI36
Celera466,238,428 - 66,291,616 (-)NCBICelera
Cytogenetic Map4q13.2NCBI
HuRef464,689,116 - 64,742,288 (-)NCBIHuRef
CHM1_1468,813,094 - 68,866,308 (-)NCBICHM1_1
T2T-CHM13v2.0471,352,520 - 71,406,589 (-)NCBIT2T-CHM13v2.0
Tmprss11a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39586,558,269 - 86,617,034 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl586,558,269 - 86,616,849 (-)EnsemblGRCm39 Ensembl
GRCm38586,410,410 - 86,469,175 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl586,410,410 - 86,468,990 (-)EnsemblGRCm38mm10GRCm38
MGSCv37586,839,435 - 86,898,015 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36587,484,971 - 87,543,551 (-)NCBIMGSCv36mm8
Celera583,639,113 - 83,697,451 (-)NCBICelera
Cytogenetic Map5E1NCBI
TMPRSS11A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1462,481,403 - 62,533,929 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl462,481,403 - 62,533,929 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0456,087,123 - 56,139,951 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TMPRSS11A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11358,412,487 - 58,484,166 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1358,432,305 - 58,482,573 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1358,349,009 - 58,384,157 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01359,128,326 - 59,158,878 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1359,127,611 - 59,177,930 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11358,771,278 - 58,806,522 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01358,266,629 - 58,317,564 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01359,272,292 - 59,307,463 (-)NCBIUU_Cfam_GSD_1.0
LOC101971520
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528517,973,627 - 18,025,045 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936582548,005 - 588,543 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936582550,285 - 588,538 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100525933
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl865,636,500 - 65,684,002 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1865,635,551 - 65,684,004 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2870,060,270 - 70,105,495 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMPRSS11A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.171,005,831 - 1,046,469 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl71,006,205 - 1,046,428 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660661,085,894 - 1,148,646 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmprss11a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624761877,617 - 949,804 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624761877,313 - 951,663 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmprss11a
442 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:23
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000075414
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 1 1
Low 2 2 8
Below cutoff 4 10 6 5 6 2 2 3 18 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000075414   ⟹   ENSRNOP00000064369
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1421,606,820 - 21,665,279 (+)Ensembl
Rnor_6.0 Ensembl1423,245,653 - 23,283,092 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110358   ⟹   ENSRNOP00000077259
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1421,606,547 - 21,665,279 (+)Ensembl
RefSeq Acc Id: XM_039092583   ⟹   XP_038948511
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21421,624,881 - 21,665,284 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038948511 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL89834 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: ENSRNOP00000064369   ⟸   ENSRNOT00000075414
RefSeq Acc Id: XP_038948511   ⟸   XM_039092583
RefSeq Acc Id: ENSRNOP00000077259   ⟸   ENSRNOT00000110358
Protein Domains
Peptidase S1   SEA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R4S3-F1-model_v2 AlphaFold M0R4S3 1-388 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596322 AgrOrtholog
BioCyc Gene G2FUF-16073 BioCyc
Ensembl Genes ENSRNOG00000046764 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000064369 ENTREZGENE
  ENSRNOP00000064369.3 UniProtKB/TrEMBL
  ENSRNOP00000077259.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075414 ENTREZGENE
  ENSRNOT00000075414.3 UniProtKB/TrEMBL
  ENSRNOT00000110358.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  3.30.70.960 UniProtKB/TrEMBL
InterPro Pept_S1A_HAT/DESC1 UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  SEA_dom UniProtKB/TrEMBL
  SEA_dom_sf UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
NCBI Gene 686581 ENTREZGENE
Pfam SEA UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PhenoGen Tmprss11a PhenoGen
PIRSF TMPRSS11ABCDE UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE SEA UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
  SSF82671 UniProtKB/TrEMBL
UniProt A0A8I5ZJF4_RAT UniProtKB/TrEMBL
  M0R4S3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-26 Tmprss11a  transmembrane serine protease 11A  Tmprss11a  transmembrane protease, serine 11A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-16 Tmprss11a  transmembrane protease, serine 11A  LOC686581  similar to transmembrane protease, serine 11A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC686581  similar to transmembrane protease, serine 11A      Symbol and Name status set to provisional 70820 PROVISIONAL