Il17d (interleukin 17D) - Rat Genome Database

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Gene: Il17d (interleukin 17D) Rattus norvegicus
Analyze
Symbol: Il17d
Name: interleukin 17D
RGD ID: 1595926
Description: Predicted to enable cytokine activity and protein homodimerization activity. Predicted to be involved in inflammatory response; negative regulation of hemopoiesis; and positive regulation of cytokine production. Predicted to be located in extracellular space. Orthologous to human IL17D (interleukin 17D); INTERACTS WITH bisphenol A; indole-3-methanol; N-acetyl-L-cysteine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: collagen alpha-1(I) chain; interleukin-17D; LOC691799; similar to interleukin 17D precursor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21531,665,795 - 31,688,840 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1533,662,656 - 33,680,148 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01534,813,340 - 34,830,832 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01533,071,419 - 33,088,912 (+)NCBIRnor_WKY
Rnor_6.01537,790,211 - 37,807,653 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1537,790,141 - 37,807,660 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01541,634,099 - 41,653,106 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41536,566,010 - 36,583,515 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1531,382,723 - 31,399,559 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Interleukin-17D Promotes Pathogenicity During Infection by Suppressing CD8 T Cell Activity. Lee Y, etal., Front Immunol. 2019 Jun 6;10:1172. doi: 10.3389/fimmu.2019.01172. eCollection 2019.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection. Seelige R, etal., Sci Rep. 2018 Sep 12;8(1):13670. doi: 10.1038/s41598-018-32011-2.
4. Interleukin-17D Aggravates Sepsis by Inhibiting Macrophage Phagocytosis. Yan X, etal., Crit Care Med. 2020 Jan;48(1):e58-e65. doi: 10.1097/CCM.0000000000004070.
Additional References at PubMed
PMID:8889548   PMID:12097364  


Genomics

Comparative Map Data
Il17d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21531,665,795 - 31,688,840 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1533,662,656 - 33,680,148 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01534,813,340 - 34,830,832 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01533,071,419 - 33,088,912 (+)NCBIRnor_WKY
Rnor_6.01537,790,211 - 37,807,653 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1537,790,141 - 37,807,660 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01541,634,099 - 41,653,106 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41536,566,010 - 36,583,515 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1531,382,723 - 31,399,559 (+)NCBICelera
Cytogenetic Map15p12NCBI
IL17D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381320,701,513 - 20,723,098 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1320,702,127 - 20,723,098 (+)EnsemblGRCh38hg38GRCh38
GRCh371321,275,652 - 21,297,237 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361320,175,482 - 20,195,237 (+)NCBINCBI36Build 36hg18NCBI36
Build 341320,175,481 - 20,195,236NCBI
Celera132,339,416 - 2,359,171 (+)NCBICelera
Cytogenetic Map13q12.11NCBI
HuRef132,080,671 - 2,100,354 (+)NCBIHuRef
CHM1_11321,245,632 - 21,265,326 (+)NCBICHM1_1
T2T-CHM13v2.01319,894,661 - 19,916,241 (+)NCBIT2T-CHM13v2.0
Il17d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391457,762,286 - 57,780,623 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1457,762,234 - 57,780,623 (+)EnsemblGRCm39 Ensembl
GRCm381457,524,829 - 57,543,166 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1457,524,777 - 57,543,166 (+)EnsemblGRCm38mm10GRCm38
MGSCv371458,143,666 - 58,162,003 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361456,479,310 - 56,497,275 (+)NCBIMGSCv36mm8
Celera1455,320,839 - 55,338,474 (+)NCBICelera
Cytogenetic Map14C3NCBI
Il17d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554971,499,700 - 1,506,557 (+)NCBIChiLan1.0ChiLan1.0
IL17D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11320,343,474 - 20,362,679 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1320,343,537 - 20,361,535 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0132,030,234 - 2,049,965 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
IL17D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12517,386,815 - 17,390,315 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2517,419,385 - 17,438,570 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02517,520,985 - 17,545,597 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12517,397,175 - 17,416,610 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02517,409,033 - 17,428,202 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02517,465,859 - 17,485,089 (-)NCBIUU_Cfam_GSD_1.0
Il17d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945119,457,556 - 119,482,058 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367201,005,101 - 1,029,617 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049367201,005,111 - 1,029,613 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL17D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl111,029,109 - 1,066,085 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1111,029,219 - 1,066,086 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.211149,861 - 192,581 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL17D
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.13401,525 - 421,725 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605744,179,514 - 44,200,905 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il17d
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477616,924,085 - 16,941,729 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477616,924,085 - 16,941,141 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il17d
29 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat

Markers in Region
AI462269  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21531,688,183 - 31,688,283 (+)MAPPERmRatBN7.2
Rnor_6.01537,807,014 - 37,807,112NCBIRnor6.0
Rnor_5.01541,652,450 - 41,652,548UniSTSRnor5.0
RGSC_v3.41536,583,040 - 36,583,138UniSTSRGSC3.4
Celera1531,398,920 - 31,399,018UniSTS
Cytogenetic Map15p12UniSTS
RH130901  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21531,670,771 - 31,670,960 (+)MAPPERmRatBN7.2
Rnor_6.01537,789,628 - 37,789,816NCBIRnor6.0
Rnor_5.01541,635,512 - 41,635,700UniSTSRnor5.0
RGSC_v3.41536,565,663 - 36,565,851UniSTSRGSC3.4
Celera1531,381,624 - 31,381,812UniSTS
RH 3.4 Map15215.3UniSTS
Cytogenetic Map15p12UniSTS
RH136357  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21531,670,699 - 31,670,907 (+)MAPPERmRatBN7.2
Rnor_6.01537,789,556 - 37,789,763NCBIRnor6.0
Rnor_5.01541,635,440 - 41,635,647UniSTSRnor5.0
RGSC_v3.41536,565,591 - 36,565,798UniSTSRGSC3.4
Celera1531,381,552 - 31,381,759UniSTS
Cytogenetic Map15p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 42 6
Low 3 43 29 13 19 13 8 11 32 35 35 11 8
Below cutoff 27 27 27

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000076285   ⟹   ENSRNOP00000068381
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1537,806,836 - 37,807,660 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076392   ⟹   ENSRNOP00000067985
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1537,790,141 - 37,790,286 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091953   ⟹   ENSRNOP00000074427
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1537,790,272 - 37,807,142 (+)Ensembl
RefSeq Acc Id: XM_039093868   ⟹   XP_038949796
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21531,665,795 - 31,688,840 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001389414 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949796 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: ENSRNOP00000068381   ⟸   ENSRNOT00000076285
RefSeq Acc Id: ENSRNOP00000067985   ⟸   ENSRNOT00000076392
RefSeq Acc Id: ENSRNOP00000074427   ⟸   ENSRNOT00000091953
RefSeq Acc Id: XP_038949796   ⟸   XM_039093868

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K812-F1-model_v2 AlphaFold A0A0G2K812 1-200 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699730
Promoter ID:EPDNEW_R10244
Type:multiple initiation site
Name:Il17d_1
Description:interleukin 17D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01537,790,142 - 37,790,202EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595926 AgrOrtholog
BioCyc Gene G2FUF-13602 BioCyc
Ensembl Genes ENSRNOG00000051120 Ensembl
NCBI Gene 691799 ENTREZGENE
PhenoGen Il17d PhenoGen


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Il17d  interleukin 17D  LOC691799  similar to interleukin 17D precursor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC691799  similar to interleukin 17D precursor  LOC682369  similar to interleukin 17D precursor  Data Merged 1643240 APPROVED
2006-11-20 LOC691799  similar to interleukin 17D precursor      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC682369  similar to interleukin 17D precursor      Symbol and Name status set to provisional 70820 PROVISIONAL