Itih6 (inter-alpha-trypsin inhibitor heavy chain family member 6) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Itih6 (inter-alpha-trypsin inhibitor heavy chain family member 6) Rattus norvegicus
Analyze
Symbol: Itih6 (Ensembl: Itih6-ps1)
Name: inter-alpha-trypsin inhibitor heavy chain family member 6 (Ensembl:inter-alpha-trypsin inhibitor heavy chain family member 6, pseudogene 1)
RGD ID: 1595851
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in hyaluronan metabolic process. Predicted to be located in extracellular region; INTERACTS WITH Cuprizon; all-trans-retinoic acid (ortholog); benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inter-alpha-trypsin inhibitor heavy chain family member 6, pseudogene 1; inter-alpha-trypsin inhibitor heavy chain family, member 6; inter-alpha-trypsin inhibitor heavy chain H6; inter-alpha-trypsin inhibitor heavy chain H6-like; Itih6-ps1; LOC100909855; LOC103692315; LOC317416; similar to inter alpha-trypsin inhibitor, heavy chain 4
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X23,180,659 - 23,217,716 (+)NCBIGRCr8
mRatBN7.2X19,753,322 - 19,790,381 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX19,753,625 - 19,789,500 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0533,156,706 - 33,169,849 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
RGSC_v3.4X40,076,102 - 40,114,077 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX20,013,333 - 20,049,465 (+)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations

Genomics

Comparative Map Data
Itih6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X23,180,659 - 23,217,716 (+)NCBIGRCr8
mRatBN7.2X19,753,322 - 19,790,381 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX19,753,625 - 19,789,500 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0533,156,706 - 33,169,849 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
RGSC_v3.4X40,076,102 - 40,114,077 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX20,013,333 - 20,049,465 (+)NCBICelera
Cytogenetic MapXq12NCBI
ITIH6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X54,748,918 - 54,798,255 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX54,748,918 - 54,798,255 (-)EnsemblGRCh38hg38GRCh38
GRCh37X54,775,351 - 54,824,688 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X54,792,341 - 54,841,398 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X54,658,636 - 54,707,694NCBI
CeleraX58,607,891 - 58,657,233 (-)NCBICelera
Cytogenetic MapXp11.22NCBI
HuRefX51,825,181 - 51,875,088 (-)NCBIHuRef
CHM1_1X54,765,887 - 54,815,229 (-)NCBICHM1_1
T2T-CHM13v2.0X54,039,799 - 54,089,136 (-)NCBIT2T-CHM13v2.0
Itih6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X149,609,892 - 149,640,732 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX149,609,968 - 149,639,936 (+)EnsemblGRCm39 Ensembl
GRCm38X150,826,917 - 150,857,407 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX150,826,972 - 150,857,053 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X147,261,515 - 147,291,486 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X146,168,406 - 146,197,659 (+)NCBIMGSCv36mm8
CeleraX133,542,671 - 133,582,356 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
ITIH6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X56,142,974 - 56,186,143 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X56,146,579 - 56,189,748 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X46,957,480 - 47,000,642 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X55,188,633 - 55,231,778 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX55,188,633 - 55,231,778 (-)Ensemblpanpan1.1panPan2
Itih6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X39,261,045 - 39,290,415 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367511,601,650 - 1,630,115 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367511,601,650 - 1,630,115 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITIH6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X47,537,909 - 47,584,419 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X53,231,323 - 53,349,651 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITIH6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X50,847,762 - 50,889,414 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX50,848,078 - 50,888,786 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660864,815,426 - 4,855,911 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itih6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462491054,671 - 70,773 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itih6
102 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat

Markers in Region
RH132138  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X19,772,970 - 19,773,176 (+)MAPPERmRatBN7.2
Rnor_6.0533,213,836 - 33,214,041NCBIRnor6.0
Rnor_5.0537,872,017 - 37,872,222UniSTSRnor5.0
RGSC_v3.4X40,097,531 - 40,097,736UniSTSRGSC3.4
CeleraX20,032,812 - 20,033,017UniSTS
Cytogenetic MapXq21UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000108873   ⟹   ENSRNOP00000096679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX19,753,625 - 19,782,908 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114911   ⟹   ENSRNOP00000084207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX19,754,549 - 19,789,500 (+)Ensembl
RefSeq Acc Id: NM_001402475   ⟹   NP_001389404
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X23,180,659 - 23,217,716 (+)NCBI
mRatBN7.2X19,753,322 - 19,790,381 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001389404 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000084207
  ENSRNOP00000084207.1
  ENSRNOP00000096679.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000096679   ⟸   ENSRNOT00000108873
RefSeq Acc Id: ENSRNOP00000084207   ⟸   ENSRNOT00000114911
RefSeq Acc Id: NP_001389404   ⟸   NM_001402475
- Peptide Label: precursor
Protein Domains
VIT   VWFA

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-2800 BioCyc
Ensembl Genes ENSRNOG00000069211 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000108873.1 UniProtKB/TrEMBL
  ENSRNOT00000114911 ENTREZGENE
  ENSRNOT00000114911.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/TrEMBL
InterPro ITI_HC_C UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
NCBI Gene 317416 ENTREZGENE
PANTHER INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER UniProtKB/TrEMBL
  INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H6 UniProtKB/TrEMBL
Pfam ITI_HC_C UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
PhenoGen Itih6 PhenoGen
PROSITE VIT UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000069211 RatGTEx
SMART VIT UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
UniProt A0A8I5ZWQ9_RAT UniProtKB/TrEMBL
  A0A8I6AQW4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-12-28 Itih6  inter-alpha-trypsin inhibitor heavy chain family member 6  Itih6  inter-alpha-trypsin inhibitor heavy chain family member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2023-12-28 Itih6  inter-alpha-trypsin inhibitor heavy chain family member 6  Itih6-ps1  inter-alpha-trypsin inhibitor heavy chain family member 6, pseudogene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-06-10 Itih6-ps1  inter-alpha-trypsin inhibitor heavy chain family member 6, pseudogene 1  Itih6  inter-alpha-trypsin inhibitor heavy chain family member 6  Symbol and Name Changed 1299863 APPROVED
2022-03-17 Itih6  inter-alpha-trypsin inhibitor heavy chain family member 6  Itih6  inter-alpha-trypsin inhibitor heavy chain family member 6  Type changed (type changed from [pseudo] to [protein-coding]) 629549 APPROVED
2022-03-17 Itih6  inter-alpha-trypsin inhibitor heavy chain family member 6  LOC317416  similar to inter alpha-trypsin inhibitor, heavy chain 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-03-17 LOC317416  similar to inter alpha-trypsin inhibitor, heavy chain 4  Itih6  inter-alpha-trypsin inhibitor heavy chain family, member 6  Data merged from RGD:6485811 737654 PROVISIONAL
2021-03-09 LOC317416  similar to inter alpha-trypsin inhibitor, heavy chain 4  LOC103692315  inter-alpha-trypsin inhibitor heavy chain H6-like  Data merged from RGD:9163857 737654 PROVISIONAL
2015-07-29 LOC103692315  inter-alpha-trypsin inhibitor heavy chain H6-like  LOC100909855  inter-alpha-trypsin inhibitor heavy chain H6-like  Data merged from RGD:6501151 737654 PROVISIONAL
2014-08-25 LOC103692315  inter-alpha-trypsin inhibitor heavy chain H6-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-08-09 Itih6  inter-alpha-trypsin inhibitor heavy chain family, member 6  LOC100912775  inter-alpha-trypsin inhibitor heavy chain H6-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100909855  inter-alpha-trypsin inhibitor heavy chain H6-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100912775  inter-alpha-trypsin inhibitor heavy chain H6-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC317416  similar to inter alpha-trypsin inhibitor, heavy chain 4      Symbol and Name status set to provisional 70820 PROVISIONAL