Urad (ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase) - Rat Genome Database

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Gene: Urad (ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase) Rattus norvegicus
Analyze
Symbol: Urad
Name: ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase
RGD ID: 1595191
Description: Predicted to enable 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity. Predicted to be involved in allantoin metabolic process; amide catabolic process; and purine-containing compound catabolic process. Predicted to be active in peroxisome. Orthologous to human URAD (ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase); INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC684055; LOC684055; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2127,709,233 - 7,718,925 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl127,709,312 - 7,718,923 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx128,394,421 - 8,403,829 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0129,017,578 - 9,026,984 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0128,045,588 - 8,054,994 (+)NCBIRnor_WKY
Rnor_6.0129,446,808 - 9,456,777 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,446,940 - 9,455,673 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01211,562,153 - 11,571,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera129,447,491 - 9,457,737 (+)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
peroxisome  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16462750  


Genomics

Comparative Map Data
Urad
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2127,709,233 - 7,718,925 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl127,709,312 - 7,718,923 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx128,394,421 - 8,403,829 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0129,017,578 - 9,026,984 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0128,045,588 - 8,054,994 (+)NCBIRnor_WKY
Rnor_6.0129,446,808 - 9,456,777 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,446,940 - 9,455,673 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01211,562,153 - 11,571,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera129,447,491 - 9,457,737 (+)NCBICelera
Cytogenetic Map12p11NCBI
URAD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381327,977,717 - 27,988,693 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1327,977,717 - 27,988,693 (-)EnsemblGRCh38hg38GRCh38
GRCh371328,551,854 - 28,562,830 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361327,450,243 - 27,460,774 (-)NCBINCBI36Build 36hg18NCBI36
Celera139,627,284 - 9,637,823 (-)NCBICelera
Cytogenetic Map13q12.2NCBI
HuRef139,372,921 - 9,383,423 (-)NCBIHuRef
CHM1_11328,520,709 - 28,531,241 (-)NCBICHM1_1
T2T-CHM13v2.01327,199,102 - 27,210,083 (-)NCBIT2T-CHM13v2.0
Urad
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395147,251,794 - 147,259,250 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5147,251,794 - 147,259,250 (-)EnsemblGRCm39 Ensembl
GRCm385147,314,984 - 147,322,440 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5147,314,984 - 147,322,440 (-)EnsemblGRCm38mm10GRCm38
MGSCv375148,126,560 - 148,134,016 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365147,625,165 - 147,636,683 (-)NCBIMGSCv36mm8
Celera5145,306,316 - 145,313,792 (-)NCBICelera
Cytogenetic Map5G3NCBI
URAD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11318,670,222 - 18,681,698 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0139,259,104 - 9,270,066 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
URAD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12511,682,304 - 11,693,143 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2511,581,206 - 11,692,284 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2511,745,604 - 11,756,396 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02511,811,279 - 11,822,095 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12511,705,882 - 11,716,673 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02511,698,288 - 11,709,123 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02511,742,263 - 11,753,054 (+)NCBIUU_Cfam_GSD_1.0
Urad
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945172,790,827 - 172,800,858 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647223,151,674 - 23,161,292 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
URAD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1115,353,524 - 5,363,481 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2115,096,514 - 5,106,242 (+)NCBISscrofa10.2Sscrofa10.2susScr3
URAD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.137,092,926 - 7,109,949 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605737,281,520 - 37,293,239 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Urad
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477610,533,806 - 10,543,091 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477610,533,806 - 10,543,091 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Urad
57 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:170
Count of miRNA genes:128
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000074791
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)127977298525593Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12390696910373166Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 29 29 29 5 3
Low 3 4 10 8 8 1 1 2 24 10 2 1
Below cutoff 26 7 2 5 2 3 3 6 13 3 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000074791   ⟹   ENSRNOP00000067429
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl127,709,312 - 7,718,923 (+)Ensembl
Rnor_6.0 Ensembl129,446,940 - 9,455,673 (+)Ensembl
RefSeq Acc Id: XM_003751121   ⟹   XP_003751169
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2127,709,233 - 7,718,925 (+)NCBI
Rnor_6.0129,446,808 - 9,456,777 (+)NCBI
Rnor_5.01211,562,153 - 11,571,615 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001385810 (Get FASTA)   NCBI Sequence Viewer  
  XP_003751169 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL89563 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003751169   ⟸   XM_003751121
- Sequence:
RefSeq Acc Id: ENSRNOP00000067429   ⟸   ENSRNOT00000074791
Protein Domains
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RCU5-F1-model_v2 AlphaFold M0RCU5 1-169 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698408
Promoter ID:EPDNEW_R8926
Type:initiation region
Name:Urad_1
Description:ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0129,446,915 - 9,446,975EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595191 AgrOrtholog
BioCyc Gene G2FUF-20117 BioCyc
BioCyc Pathway PWY-5691 [urate conversion to allantoin I] BioCyc
Ensembl Genes ENSRNOG00000050360 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000067429 ENTREZGENE
  ENSRNOP00000067429.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074791 ENTREZGENE
  ENSRNOT00000074791.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.3330.10 UniProtKB/TrEMBL
InterPro OHCU_decarboxylase UniProtKB/TrEMBL
  OHCU_decarboxylase-1 UniProtKB/TrEMBL
  OHCU_decarboxylase_sf UniProtKB/TrEMBL
KEGG Report rno:684055 UniProtKB/TrEMBL
NCBI Gene 684055 ENTREZGENE
PANTHER 2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED UniProtKB/TrEMBL
  2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED UniProtKB/TrEMBL
Pfam OHCU_decarbox UniProtKB/TrEMBL
PhenoGen Urad PhenoGen
Superfamily-SCOP SSF158694 UniProtKB/TrEMBL
TIGRFAMs UHCUDC UniProtKB/TrEMBL
UniProt M0RCU5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-13 Urad  ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase  LOC684055  hypothetical protein LOC684055  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC684055  hypothetical protein LOC684055      Symbol and Name status set to provisional 70820 PROVISIONAL