Fmo9 (flavin containing monooxygenase 9) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Fmo9 (flavin containing monooxygenase 9) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Fmo9
Name: flavin containing monooxygenase 9
RGD ID: 1595083
Description: Predicted to enable N,N-dimethylaniline monooxygenase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: flavin containing monooxygenase 9 pseudogene; Fmo9p; LOC685365; similar to flavin containing monooxygenase 5
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81381,353,044 - 81,374,033 (-)NCBIGRCr8
mRatBN7.21378,820,080 - 78,841,075 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1378,820,080 - 78,841,075 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1381,439,561 - 81,460,585 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01382,753,103 - 82,774,124 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01379,991,404 - 80,012,416 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01384,774,274 - 84,795,081 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1384,774,274 - 84,795,081 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01389,648,149 - 89,668,956 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41382,305,221 - 82,326,535 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1378,527,996 - 78,549,015 (-)NCBICelera
Cytogenetic Map13q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Fmo9
104 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:110
Interacting mature miRNAs:131
Transcripts:ENSRNOT00000029706
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)137402391880753406Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium
Low 8 1 1
Below cutoff 1 1 35 10 15 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000029706   ⟹   ENSRNOP00000036759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1378,820,080 - 78,841,075 (-)Ensembl
Rnor_6.0 Ensembl1384,774,274 - 84,795,081 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076083   ⟹   ENSRNOP00000068061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1384,774,754 - 84,795,070 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076886   ⟹   ENSRNOP00000068224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1384,774,754 - 84,793,463 (-)Ensembl
RefSeq Acc Id: NM_001109466   ⟹   NP_001102936
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81381,353,044 - 81,374,033 (-)NCBI
mRatBN7.21378,820,080 - 78,841,075 (-)NCBI
Rnor_6.01384,774,274 - 84,795,081 (-)NCBI
Rnor_5.01389,648,149 - 89,668,956 (-)NCBI
RGSC_v3.41382,305,221 - 82,326,535 (-)RGD
Celera1378,527,996 - 78,549,015 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102936 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM09291 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036759
  ENSRNOP00000036759.4
Reference Protein Sequences
RefSeq Acc Id: NP_001102936   ⟸   NM_001109466
- UniProtKB: D3ZD07 (UniProtKB/TrEMBL),   A6IDK6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068224   ⟸   ENSRNOT00000076886
RefSeq Acc Id: ENSRNOP00000036759   ⟸   ENSRNOT00000029706
RefSeq Acc Id: ENSRNOP00000068061   ⟸   ENSRNOT00000076083

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZD07-F1-model_v2 AlphaFold D3ZD07 1-543 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595083 AgrOrtholog
BioCyc Gene G2FUF-17535 BioCyc
Ensembl Genes ENSRNOG00000025119 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029706 ENTREZGENE
  ENSRNOT00000029706.7 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/TrEMBL
  Flavin_mOase UniProtKB/TrEMBL
  Flavin_mOase-like UniProtKB/TrEMBL
  Flavin_mOase_5 UniProtKB/TrEMBL
KEGG Report rno:685365 UniProtKB/TrEMBL
NCBI Gene 685365 ENTREZGENE
PANTHER DIMETHYLANILINE MONOOXYGENASE UniProtKB/TrEMBL
  DIMETHYLANILINE MONOOXYGENASE [N-OXIDE-FORMING] UniProtKB/TrEMBL
Pfam FMO-like UniProtKB/TrEMBL
PhenoGen Fmo9 PhenoGen
PIRSF FMO UniProtKB/TrEMBL
PRINTS FMOXYGENASE UniProtKB/TrEMBL
  FMOXYGENASE5 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025119 RatGTEx
Superfamily-SCOP SSF51905 UniProtKB/TrEMBL
UniProt A6IDK6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZD07 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-05 Fmo9  flavin containing monooxygenase 9  Fmo9p  flavin containing monooxygenase 9 pseudogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 Fmo9  flavin containing monooxygenase 9  LOC686830  similar to flavin containing monooxygenase 5  Data merged from RGD:1592519 1643240 APPROVED
2008-03-05 Fmo9  flavin containing monooxygenase 9  LOC685365  similar to flavin containing monooxygenase 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC685365  similar to flavin containing monooxygenase 5      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC686830  similar to flavin containing monooxygenase 5      Symbol and Name status set to provisional 70820 PROVISIONAL