Ipo8 (importin 8) - Rat Genome Database

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Gene: Ipo8 (importin 8) Rattus norvegicus
Analyze
Symbol: Ipo8 (Ensembl: AABR07062570.1)
Name: importin 8
RGD ID: 1593688
Description: Predicted to enable small GTPase binding activity. Orthologous to human IPO8 (importin 8); INTERACTS WITH amphetamine; 1,2-dimethylhydrazine (ortholog); 1-chloro-2,4-dinitrobenzene (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AABR07062570.1; importin-8; LOC686774; similar to Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24181,729,216 - 181,793,673 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4181,729,220 - 181,793,161 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4187,999,563 - 188,064,053 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04183,784,091 - 183,848,583 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04182,404,583 - 182,469,077 (-)NCBIRnor_WKY
Rnor_6.04183,228,688 - 183,295,253 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4183,229,985 - 183,293,999 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.04247,359,871 - 247,424,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera4170,197,109 - 170,259,830 (-)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:25968067  


Genomics

Comparative Map Data
Ipo8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24181,729,216 - 181,793,673 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4181,729,220 - 181,793,161 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4187,999,563 - 188,064,053 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04183,784,091 - 183,848,583 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04182,404,583 - 182,469,077 (-)NCBIRnor_WKY
Rnor_6.04183,228,688 - 183,295,253 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4183,229,985 - 183,293,999 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.04247,359,871 - 247,424,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera4170,197,109 - 170,259,830 (-)NCBICelera
Cytogenetic Map4q44NCBI
IPO8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381230,628,988 - 30,695,869 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1230,628,988 - 30,695,869 (-)EnsemblGRCh38hg38GRCh38
GRCh371230,781,922 - 30,848,803 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361230,673,189 - 30,740,018 (-)NCBINCBI36Build 36hg18NCBI36
Build 341230,673,189 - 30,740,018NCBI
Celera1235,924,748 - 35,991,765 (-)NCBICelera
Cytogenetic Map12p11.21NCBI
HuRef1230,547,280 - 30,614,305 (-)NCBIHuRef
CHM1_11230,746,941 - 30,813,955 (-)NCBICHM1_1
T2T-CHM13v2.01230,503,650 - 30,570,532 (-)NCBIT2T-CHM13v2.0
Ipo8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396148,672,181 - 148,732,980 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6148,672,181 - 148,732,965 (-)EnsemblGRCm39 Ensembl
GRCm386148,770,683 - 148,832,931 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6148,770,683 - 148,831,467 (-)EnsemblGRCm38mm10GRCm38
MGSCv376148,719,206 - 148,779,989 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366148,727,854 - 148,788,637 (-)NCBIMGSCv36mm8
Celera6151,807,825 - 151,869,431 (-)NCBICelera
Cytogenetic Map6G3NCBI
Ipo8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555054,490,598 - 4,575,213 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555054,490,738 - 4,574,969 (+)NCBIChiLan1.0ChiLan1.0
IPO8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11258,216,536 - 58,282,985 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1258,216,536 - 58,282,985 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01255,588,898 - 55,655,894 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
IPO8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12717,568,938 - 17,640,719 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2717,568,937 - 17,638,842 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2728,778,208 - 28,849,711 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02717,751,925 - 17,823,426 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2717,751,905 - 17,823,419 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12717,561,215 - 17,632,884 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02717,592,139 - 17,663,736 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02728,930,300 - 29,001,855 (-)NCBIUU_Cfam_GSD_1.0
LOC101961741
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494578,176,690 - 78,242,056 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366075,009,972 - 5,159,341 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IPO8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl543,099,749 - 43,182,803 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1543,099,749 - 43,182,807 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2546,786,263 - 46,869,197 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IPO8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11130,314,477 - 30,381,306 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1130,314,201 - 30,381,241 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660694,617,262 - 4,684,748 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ipo8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247785,099,647 - 5,195,012 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247785,099,360 - 5,196,880 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ipo8
263 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:83
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000070949
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

Markers in Region
RH128008  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24181,729,442 - 181,729,642 (+)MAPPERmRatBN7.2
Rnor_6.04183,223,146 - 183,223,345NCBIRnor6.0
Rnor_5.04247,354,495 - 247,354,694UniSTSRnor5.0
Celera4170,197,336 - 170,197,535UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000079695   ⟹   ENSRNOP00000073839
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4181,729,220 - 181,793,161 (-)Ensembl
RefSeq Acc Id: XM_039108919   ⟹   XP_038964847
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24181,729,216 - 181,793,672 (-)NCBI
RefSeq Acc Id: XM_039108920   ⟹   XP_038964848
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24181,729,216 - 181,793,673 (-)NCBI
RefSeq Acc Id: XM_039108921   ⟹   XP_038964849
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24181,729,216 - 181,786,815 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001387811 (Get FASTA)   NCBI Sequence Viewer  
  XP_038964847 (Get FASTA)   NCBI Sequence Viewer  
  XP_038964848 (Get FASTA)   NCBI Sequence Viewer  
  XP_038964849 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_038964848   ⟸   XM_039108920
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038964847   ⟸   XM_039108919
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038964849   ⟸   XM_039108921
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000073839   ⟸   ENSRNOT00000079695
Protein Domains
Importin N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K6J6-F1-model_v2 AlphaFold A0A0G2K6J6 1-966 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593688 AgrOrtholog
BioCyc Gene G2FUF-42376 BioCyc
Ensembl Genes ENSRNOG00000056041 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000073839 ENTREZGENE
  ENSRNOP00000073839.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079695 ENTREZGENE
  ENSRNOT00000079695.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Importin-beta_N UniProtKB/TrEMBL
  XPO2_central UniProtKB/TrEMBL
NCBI Gene 686774 ENTREZGENE
Pfam Cse1 UniProtKB/TrEMBL
  IBN_N UniProtKB/TrEMBL
PhenoGen Ipo8 PhenoGen
PROSITE IMPORTIN_B_NT UniProtKB/TrEMBL
SMART IBN_N UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt A0A0G2K6J6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Ipo8  importin 8  AABR07062570.1    Data Merged 737654 PROVISIONAL
2019-11-08 AABR07062570.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2019-08-08 Ipo8  importin 8  LOC686774  similar to Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC686774  similar to Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8)      Symbol and Name status set to provisional 70820 PROVISIONAL