Pebp4 (phosphatidylethanolamine binding protein 4) - Rat Genome Database

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Gene: Pebp4 (phosphatidylethanolamine binding protein 4) Rattus norvegicus
Analyze
Symbol: Pebp4
Name: phosphatidylethanolamine binding protein 4
RGD ID: 1593295
Description: Orthologous to human PEBP4 (phosphatidylethanolamine binding protein 4); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; amitrole.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AABR07018326.1; LOC691997; phosphatidylethanolamine-binding protein 4; similar to PEBP family protein precursor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Pebp4Tn(sb-T2/Bart3)2.299Mcwi  
Genetic Models: F344-Pebp4Tn(sb-T2/Bart3)2.299Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81551,328,127 - 51,543,920 (+)NCBIGRCr8
mRatBN7.21544,920,946 - 45,134,188 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1544,921,886 - 45,134,191 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01551,644,948 - 51,740,626 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.01551,528,587 - 51,615,204 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1551,528,514 - 51,740,281 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01555,252,902 - 55,466,149 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,225,405 - 50,460,627 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1544,602,584 - 44,814,601 (+)NCBICelera
Cytogenetic Map15p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:21873635   PMID:23533145  


Genomics

Comparative Map Data
Pebp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81551,328,127 - 51,543,920 (+)NCBIGRCr8
mRatBN7.21544,920,946 - 45,134,188 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1544,921,886 - 45,134,191 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01551,644,948 - 51,740,626 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.01551,528,587 - 51,615,204 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1551,528,514 - 51,740,281 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01555,252,902 - 55,466,149 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,225,405 - 50,460,627 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1544,602,584 - 44,814,601 (+)NCBICelera
Cytogenetic Map15p11NCBI
PEBP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38822,713,251 - 22,941,077 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl822,713,251 - 23,000,000 (-)EnsemblGRCh38hg38GRCh38
GRCh37822,570,764 - 22,798,590 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,626,710 - 22,841,366 (-)NCBINCBI36Build 36hg18NCBI36
Celera821,533,122 - 21,747,804 (-)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef821,113,907 - 21,329,903 (-)NCBIHuRef
CHM1_1822,773,101 - 22,987,671 (-)NCBICHM1_1
T2T-CHM13v2.0822,987,819 - 23,216,048 (-)NCBIT2T-CHM13v2.0
Pebp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,077,856 - 70,297,367 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,077,869 - 70,297,367 (+)EnsemblGRCm39 Ensembl
GRCm381469,840,407 - 70,059,918 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1469,840,420 - 70,059,918 (+)EnsemblGRCm38mm10GRCm38
MGSCv371470,240,227 - 70,459,693 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361468,575,487 - 68,794,959 (+)NCBIMGSCv36mm8
Celera1467,378,541 - 67,600,399 (+)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.1NCBI
Pebp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540346,125,150 - 46,333,200 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540346,126,263 - 46,317,830 (-)NCBIChiLan1.0ChiLan1.0
PEBP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2741,218,356 - 41,505,203 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1816,945,744 - 17,232,411 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0821,963,297 - 22,250,024 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1818,902,616 - 19,117,229 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl818,902,734 - 19,117,025 (-)Ensemblpanpan1.1panPan2
PEBP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12534,329,160 - 34,574,086 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2534,317,421 - 34,574,066 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2534,917,144 - 35,164,286 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02534,536,708 - 34,784,007 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2534,535,120 - 34,784,085 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12534,483,438 - 34,730,274 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02534,337,758 - 34,584,606 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02534,492,754 - 34,740,068 (+)NCBIUU_Cfam_GSD_1.0
Pebp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494311,922,656 - 12,137,275 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365556,433,237 - 6,620,072 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365556,433,243 - 6,648,014 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PEBP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl146,966,862 - 7,173,347 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1146,966,861 - 7,173,255 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2147,446,928 - 7,543,617 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2147,691,260 - 7,698,221 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PEBP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1820,792,718 - 21,066,746 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl820,792,707 - 21,004,134 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605221,223,048 - 21,434,545 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pebp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475818,203,239 - 18,394,891 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pebp4
504 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:131
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000039454
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154063126846187442Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat

Markers in Region
28.MMHAP16FRB10.seq  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21545,054,716 - 45,054,885 (+)MAPPERmRatBN7.2
Rnor_6.01551,660,824 - 51,660,992NCBIRnor6.0
Rnor_5.01555,386,302 - 55,386,470UniSTSRnor5.0
RGSC_v3.41550,381,198 - 50,381,366UniSTSRGSC3.4
Celera1544,734,796 - 44,734,964UniSTS
Cytogenetic Map15p11UniSTS
D17S1860  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21545,133,859 - 45,134,514 (+)MAPPERmRatBN7.2
Rnor_6.01551,739,958 - 51,740,612NCBIRnor6.0
Rnor_5.01555,465,805 - 55,466,459UniSTSRnor5.0
RGSC_v3.41550,460,302 - 50,460,956UniSTSRGSC3.4
Celera1544,813,933 - 44,814,587UniSTS
Cytogenetic Map15p11UniSTS


Genetic Models
This gene Pebp4 is modified in the following models/strains:


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000093193   ⟹   ENSRNOP00000095653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1544,921,886 - 45,134,191 (+)Ensembl
RefSeq Acc Id: XM_008770836   ⟹   XP_008769058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,328,127 - 51,543,920 (+)NCBI
mRatBN7.21544,920,954 - 45,134,188 (+)NCBI
Rnor_6.01551,644,948 - 51,740,626 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039093942   ⟹   XP_038949870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,328,127 - 51,543,818 (+)NCBI
mRatBN7.21544,920,946 - 45,134,044 (+)NCBI
RefSeq Acc Id: XM_063274888   ⟹   XP_063130958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,328,127 - 51,543,920 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008769058 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949870 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130958 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM02197 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000095653
  ENSRNOP00000095653.1
RefSeq Acc Id: XP_008769058   ⟸   XM_008770836
- Peptide Label: isoform X1
- UniProtKB: A6HTI3 (UniProtKB/TrEMBL),   A0A8I6GL87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038949870   ⟸   XM_039093942
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GL87 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000095653   ⟸   ENSRNOT00000093193
RefSeq Acc Id: XP_063130958   ⟸   XM_063274888
- Peptide Label: isoform X3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593295 AgrOrtholog
BioCyc Gene G2FUF-13246 BioCyc
Ensembl Genes ENSRNOG00000026247 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000093193.2 UniProtKB/TrEMBL
Gene3D-CATH 3.90.280.10 UniProtKB/TrEMBL
InterPro PEBP UniProtKB/TrEMBL
  PEBP-like_sf UniProtKB/TrEMBL
  PEBP_euk UniProtKB/TrEMBL
  Phosphatidylethanolamine-bd_CS UniProtKB/TrEMBL
NCBI Gene 691997 ENTREZGENE
PANTHER PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4 UniProtKB/TrEMBL
  PTHR11362 UniProtKB/TrEMBL
Pfam PBP UniProtKB/TrEMBL
PhenoGen Pebp4 PhenoGen
PROSITE PBP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026247 RatGTEx
Superfamily-SCOP SSF49777 UniProtKB/TrEMBL
UniProt A0A8I6GL87 ENTREZGENE, UniProtKB/TrEMBL
  A6HTI3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Pebp4  phosphatidylethanolamine binding protein 4  AABR07018326.1    Data merged from RGD:15003630 737654 PROVISIONAL
2019-11-08 AABR07018326.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2008-12-02 Pebp4  phosphatidylethanolamine binding protein 4  Pebp4  phosphatidylethanolamine-binding protein 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Pebp4  phosphatidylethanolamine-binding protein 4  LOC691997  similar to PEBP family protein precursor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC691997  similar to PEBP family protein precursor  LOC684210  similar to PEBP family protein precursor  Data merged from RGD:1592735 1643240 APPROVED
2006-11-20 LOC691997  similar to PEBP family protein precursor      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC684210  similar to PEBP family protein precursor      Symbol and Name status set to provisional 70820 PROVISIONAL