Degs1l1 (delta(4)-desaturase, sphingolipid 1 like 1) - Rat Genome Database

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Gene: Degs1l1 (delta(4)-desaturase, sphingolipid 1 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Degs1l1 (Ensembl: LOC498300)
Name: delta(4)-desaturase, sphingolipid 1 like 1 (Ensembl:similar to degenerative spermatocyte homolog)
RGD ID: 1593185
Description: Predicted to enable sphingolipid delta-4 desaturase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 18. Orthologous to human DEGS1 (delta 4-desaturase, sphingolipid 1).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: epoxide hydrolase 1-like; LOC498300; LOC690147; similar to degenerative spermatocyte homolog; similar to Epoxide hydrolase 1 (Microsomal epoxide hydrolase) (Epoxide hydratase); sphingolipid delta(4)-desaturase DES1; sphingolipid delta(4)-desaturase DES1-like
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81395,304,394 - 95,351,648 (+)NCBIGRCr8
mRatBN7.21392,772,654 - 92,818,811 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1392,772,649 - 92,818,574 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01399,369,102 - 99,374,051 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1399,369,126 - 99,374,033 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013104,366,151 - 104,371,785 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,810,096 - 96,826,342 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1392,353,592 - 92,358,820 (+)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Degs1l1
631 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:55
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000072695
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium
Low 16 3 11
Below cutoff 1 2 36 29 9 29 23 15 23

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000072695   ⟹   ENSRNOP00000066329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1392,772,649 - 92,818,574 (+)Ensembl
Rnor_6.0 Ensembl1399,369,126 - 99,374,033 (+)Ensembl
RefSeq Acc Id: XM_039091475   ⟹   XP_038947403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81395,310,053 - 95,351,648 (+)NCBI
mRatBN7.21392,778,305 - 92,818,811 (+)NCBI
RefSeq Acc Id: XM_039091476   ⟹   XP_038947404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81395,304,394 - 95,346,950 (+)NCBI
mRatBN7.21392,772,654 - 92,818,811 (+)NCBI
RefSeq Acc Id: XM_063272770   ⟹   XP_063128840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81395,310,069 - 95,346,950 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038947403 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947404 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128840 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL94847 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066329.2
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000066329   ⟸   ENSRNOT00000072695
RefSeq Acc Id: XP_038947404   ⟸   XM_039091476
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038947403   ⟸   XM_039091475
- Peptide Label: isoform X2
- UniProtKB: M0R9Z4 (UniProtKB/TrEMBL),   A6JGJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128840   ⟸   XM_063272770
- Peptide Label: isoform X1
Protein Domains
Fatty acid desaturase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593185 AgrOrtholog
BioCyc Gene G2FUF-17103 BioCyc
Ensembl Genes ENSRNOG00000050163 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072695.2 UniProtKB/TrEMBL
InterPro FA_desaturase_dom UniProtKB/TrEMBL
NCBI Gene 498300 ENTREZGENE
PANTHER SPHINGOLIPID 4-DESATURASE UniProtKB/TrEMBL
  SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2 UniProtKB/TrEMBL
Pfam FA_desaturase UniProtKB/TrEMBL
PhenoGen Degs1l1 PhenoGen
RatGTEx ENSRNOG00000050163 RatGTEx
UniProt A6JGJ1 ENTREZGENE, UniProtKB/TrEMBL
  M0R9Z4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Degs1l1  delta(4)-desaturase, sphingolipid 1 like 1  LOC498300  similar to degenerative spermatocyte homolog  Symbol and Name Changed 1299863 APPROVED
2021-03-09 LOC498300  similar to degenerative spermatocyte homolog  LOC690147  similar to Epoxide hydrolase 1 (Microsomal epoxide hydrolase) (Epoxide hydratase)  Data merged from RGD:1584022 737654 PROVISIONAL
2006-11-20 LOC498300  similar to degenerative spermatocyte homolog      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC690147  similar to Epoxide hydrolase 1 (Microsomal epoxide hydrolase) (Epoxide hydratase)      Symbol and Name status set to provisional 70820 PROVISIONAL