Gene: Pappa2 (pappalysin 2) Rattus norvegicus
Symbol: Pappa2
Name: pappalysin 2
Description: ENCODES a protein that exhibits metalloendopeptidase activity (ortholog); metallopeptidase activity (ortholog); INVOLVED IN response to salt stress; bone morphogenesis (ortholog); proteolysis (ortholog); ASSOCIATED WITH abnormal circadian regulation of systemic arterial blood pressure; salt-sensitive hypertension; FOUND IN apical plasma membrane; cytosol; INTERACTS WITH bisphenol A; aflatoxin B1 (ortholog); all-trans-retinoic acid (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC680069; LOC680415; pappalysin-2; similar to pappalysin 2 isoform 1; similar to Pappalysin-2 precursor (Pregnancy-associated plasma protein-A2) (PAPP-A2) (Pregnancy-associated plasma protein-E1) (PAPP-E)
Homo sapiens (human) : PAPPA2 (pappalysin 2)  HGNC  Alliance
Mus musculus (house mouse) : Pappa2 (pappalysin 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pappa2 (pappalysin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PAPPA2 (pappalysin 2)
Canis lupus familiaris (dog) : PAPPA2 (pappalysin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pappa2 (pappalysin 2)
more info ...
Allele / Splice: Pappa2em4Mcwi   Pappa2em5Mcwi  
Genetic Models: SS.BN-(D13Hmgc1048-D13Hmgc1050)-Pappa2em4Mcwi SS.BN-(D13Hmgc1048-D13Hmgc1050)-Pappa2em5Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01376,389,150 - 76,660,248 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01381,303,663 - 81,574,402 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41374,286,881 - 74,379,736 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1370,687,413 - 70,959,267 (-)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
More on Pappa2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1591785
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2018-03-13
Status: ACTIVE