Sgsh (N-sulfoglucosamine sulfohydrolase) - Rat Genome Database

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Gene: Sgsh (N-sulfoglucosamine sulfohydrolase) Rattus norvegicus
Analyze
Symbol: Sgsh
Name: N-sulfoglucosamine sulfohydrolase
RGD ID: 1591134
Description: Predicted to enable N-sulfoglucosamine sulfohydrolase activity and sulfuric ester hydrolase activity. Predicted to be involved in glycosaminoglycan catabolic process and heparan sulfate proteoglycan catabolic process. Predicted to act upstream of or within determination of adult lifespan and motor behavior. Predicted to be located in lysosome. Predicted to be active in lysosomal lumen. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIIA. Orthologous to human SGSH (N-sulfoglucosamine sulfohydrolase); INTERACTS WITH 1,2-dimethylhydrazine (ortholog); 17beta-estradiol (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC688293; N-sulphoglucosamine sulphohydrolase; similar to N-sulfoglucosamine sulfohydrolase (sulfamidase)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810105,095,336 - 105,112,037 (-)NCBIGRCr8
mRatBN7.210104,596,810 - 104,613,510 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10104,598,112 - 104,613,486 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.010108,469,312 - 108,479,094 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.010108,075,298 - 108,085,523 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10103,150,568 - 103,160,450 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7493035   PMID:15146460   PMID:15962010   PMID:21873635   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Sgsh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810105,095,336 - 105,112,037 (-)NCBIGRCr8
mRatBN7.210104,596,810 - 104,613,510 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10104,598,112 - 104,613,486 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.010108,469,312 - 108,479,094 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.010108,075,298 - 108,085,523 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10103,150,568 - 103,160,450 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
SGSH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381780,200,673 - 80,220,333 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1780,206,716 - 80,220,923 (-)EnsemblGRCh38hg38GRCh38
GRCh371778,183,075 - 78,194,132 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361775,797,685 - 75,808,719 (-)NCBINCBI36Build 36hg18NCBI36
Build 341775,797,684 - 75,808,719NCBI
Celera1774,812,270 - 74,823,389 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1773,623,348 - 73,634,467 (-)NCBIHuRef
CHM1_11778,269,258 - 78,280,378 (-)NCBICHM1_1
T2T-CHM13v2.01781,101,075 - 81,120,754 (-)NCBIT2T-CHM13v2.0
Sgsh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911119,234,315 - 119,246,336 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11119,234,251 - 119,246,362 (-)EnsemblGRCm39 Ensembl
GRCm3811119,343,489 - 119,355,510 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11119,343,425 - 119,355,536 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711119,204,803 - 119,216,824 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611119,159,582 - 119,171,592 (-)NCBIMGSCv36mm8
Celera11131,091,260 - 131,103,792 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1183.36NCBI
Sgsh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555062,701,905 - 2,711,073 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555062,701,901 - 2,713,431 (+)NCBIChiLan1.0ChiLan1.0
SGSH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21996,788,953 - 96,800,097 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117101,688,706 - 101,699,811 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01774,636,854 - 74,647,958 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11780,370,641 - 80,381,698 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1780,371,790 - 80,381,703 (-)Ensemblpanpan1.1panPan2
SGSH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.191,540,933 - 1,547,029 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl91,540,932 - 1,547,029 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha92,180,762 - 2,186,880 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.092,173,239 - 2,179,357 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl92,173,260 - 2,179,905 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.192,196,651 - 2,202,770 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.092,322,098 - 2,328,214 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.092,403,348 - 2,409,505 (+)NCBIUU_Cfam_GSD_1.0
Sgsh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056022,208,133 - 2,216,751 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365944,193,983 - 4,204,008 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365944,195,217 - 4,203,802 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SGSH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl122,241,840 - 2,248,376 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1122,241,824 - 2,248,388 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2122,193,028 - 2,199,570 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SGSH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11672,192,559 - 72,203,230 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1672,190,310 - 72,203,130 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607743,494,846 - 43,506,201 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sgsh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248019,285,806 - 9,297,151 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248019,287,776 - 9,297,164 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sgsh
231 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:68
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000070934
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
631539Oia6Oil induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1097010147104670812Rat


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000093976   ⟹   ENSRNOP00000084730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10104,598,112 - 104,605,768 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098505   ⟹   ENSRNOP00000084506
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10104,598,112 - 104,613,486 (-)Ensembl
RefSeq Acc Id: NM_001427070   ⟹   NP_001413999
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810105,095,336 - 105,112,009 (-)NCBI
RefSeq Acc Id: XM_039087538   ⟹   XP_038943466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810105,100,432 - 105,112,037 (-)NCBI
mRatBN7.210104,596,810 - 104,613,510 (-)NCBI
RefSeq Acc Id: XM_039087539   ⟹   XP_038943467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810105,100,432 - 105,105,827 (-)NCBI
mRatBN7.210104,596,810 - 104,607,306 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001413999 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943466 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943467 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000084506.1
  ENSRNOP00000084730
  ENSRNOP00000084730.1
RefSeq Acc Id: XP_038943466   ⟸   XM_039087538
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038943467   ⟸   XM_039087539
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A071 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000084730   ⟸   ENSRNOT00000093976
RefSeq Acc Id: ENSRNOP00000084506   ⟸   ENSRNOT00000098505
RefSeq Acc Id: NP_001413999   ⟸   NM_001427070
- Peptide Label: precursor
- UniProtKB: A0A8I5ZZ84 (UniProtKB/TrEMBL)
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591134 AgrOrtholog
BioCyc Gene G2FUF-22491 BioCyc
Ensembl Genes ENSRNOG00000064880 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000093976.1 UniProtKB/TrEMBL
  ENSRNOT00000098505.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.720.10 UniProtKB/TrEMBL
InterPro Alkaline_phosphatase_core_sf UniProtKB/TrEMBL
  DUF4976 UniProtKB/TrEMBL
  Sulfatase_CS UniProtKB/TrEMBL
  Sulfatase_N UniProtKB/TrEMBL
NCBI Gene 688293 ENTREZGENE
PANTHER N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER UniProtKB/TrEMBL
  N-SULPHOGLUCOSAMINE SULPHOHYDROLASE UniProtKB/TrEMBL
Pfam DUF4976 UniProtKB/TrEMBL
  Sulfatase UniProtKB/TrEMBL
PhenoGen Sgsh PhenoGen
PROSITE SULFATASE_1 UniProtKB/TrEMBL
  SULFATASE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000064880 RatGTEx
Superfamily-SCOP SSF53649 UniProtKB/TrEMBL
UniProt A0A8I5ZZ84 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A071 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Sgsh  N-sulfoglucosamine sulfohydrolase  Sgsh  N-sulfoglucosamine sulfohydrolase  Data merged from RGD:149736474 737654 PROVISIONAL
2021-08-09 Sgsh  N-sulfoglucosamine sulfohydrolase      Symbol and Name status set to provisional 45752 PROVISIONAL
2013-08-16 Sgsh  N-sulfoglucosamine sulfohydrolase  LOC688293  similar to N-sulfoglucosamine sulfohydrolase (sulfamidase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC688293  similar to N-sulfoglucosamine sulfohydrolase (sulfamidase)      Symbol and Name status set to provisional 70820 PROVISIONAL