Dennd1c (DENN domain containing 1C) - Rat Genome Database

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Gene: Dennd1c (DENN domain containing 1C) Rattus norvegicus
Analyze
Symbol: Dennd1c
Name: DENN domain containing 1C
RGD ID: 1590869
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in centrosome; cytosol; and nucleoplasm. Orthologous to human DENND1C (DENN domain containing 1C); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DENN domain-containing protein 1C; DENN/MADD domain containing 1C; hypothetical LOC363326; hypothetical protein LOC363326; LOC363326; uncharacterized protein LOC363326
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,991,035 - 2,003,330 (-)NCBIGRCr8
mRatBN7.291,904,040 - 1,916,329 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,904,045 - 1,916,187 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,337,981 - 2,350,194 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,687,338 - 7,699,561 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,643,199 - 6,655,410 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.099,976,015 - 9,982,349 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,970,209 - 9,982,295 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.098,975,081 - 8,981,202 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,607,526 - 6,613,422 (+)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation. Klip A, etal., Am J Physiol Cell Physiol. 2014 May 15;306(10):C879-86. doi: 10.1152/ajpcell.00069.2014. Epub 2014 Mar 5.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:20937701  


Genomics

Comparative Map Data
Dennd1c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,991,035 - 2,003,330 (-)NCBIGRCr8
mRatBN7.291,904,040 - 1,916,329 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,904,045 - 1,916,187 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,337,981 - 2,350,194 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,687,338 - 7,699,561 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,643,199 - 6,655,410 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.099,976,015 - 9,982,349 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,970,209 - 9,982,295 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.098,975,081 - 8,981,202 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,607,526 - 6,613,422 (+)NCBICelera
Cytogenetic Map9q11NCBI
DENND1C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,467,207 - 6,481,787 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,467,207 - 6,482,557 (-)EnsemblGRCh38hg38GRCh38
GRCh37196,467,218 - 6,481,798 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,418,218 - 6,432,798 (-)NCBINCBI36Build 36hg18NCBI36
Build 34196,418,218 - 6,432,798NCBI
Celera196,407,044 - 6,421,624 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef196,230,008 - 6,244,590 (-)NCBIHuRef
CHM1_1196,466,801 - 6,481,386 (-)NCBICHM1_1
T2T-CHM13v2.0196,456,694 - 6,471,589 (-)NCBIT2T-CHM13v2.0
Dennd1c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,373,051 - 57,385,518 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,372,905 - 57,385,514 (-)EnsemblGRCm39 Ensembl
GRCm381757,066,051 - 57,078,529 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,065,905 - 57,078,514 (-)EnsemblGRCm38mm10GRCm38
MGSCv371757,205,478 - 57,217,933 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,751,202 - 56,763,763 (-)NCBIMGSCv36mm8
Celera1761,413,975 - 61,426,430 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.65NCBI
Dennd1c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,140,480 - 3,148,334 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554953,139,411 - 3,148,389 (+)NCBIChiLan1.0ChiLan1.0
DENND1C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22010,875,444 - 10,897,030 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11910,101,369 - 10,122,942 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0195,495,078 - 5,516,532 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1196,417,475 - 6,431,537 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,417,475 - 6,433,162 (-)Ensemblpanpan1.1panPan2
DENND1C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,704,347 - 53,717,842 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,708,889 - 53,717,855 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,455,866 - 53,464,870 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02054,362,792 - 54,371,795 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,362,840 - 54,371,788 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,429,646 - 53,438,646 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,878,086 - 53,887,084 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,107,060 - 54,116,064 (+)NCBIUU_Cfam_GSD_1.0
Dennd1c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,013,738 - 214,022,881 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365883,811,792 - 3,820,346 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DENND1C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,610,566 - 72,620,209 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1272,610,543 - 72,620,212 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,970,560 - 72,980,209 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DENND1C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,070,956 - 6,086,727 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl66,070,064 - 6,084,946 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660811,911,605 - 1,927,053 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dennd1c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248283,578,479 - 3,587,182 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dennd1c
41 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:56
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000075215
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat

Markers in Region
AU015179  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,903,660 - 1,903,786 (-)MAPPERmRatBN7.2
Rnor_6.099,982,603 - 9,982,728NCBIRnor6.0
Rnor_5.098,981,456 - 8,981,581UniSTSRnor5.0
Celera96,613,676 - 6,613,801UniSTS
Cytogenetic Map9q11UniSTS
RH138434  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera96,611,366 - 6,611,494UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 19 5
Low 1 30 49 41 41 8 9 72 33 34 6 8
Below cutoff 13 2 2 2 7

Sequence


RefSeq Acc Id: ENSRNOT00000075215   ⟹   ENSRNOP00000067003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,904,045 - 1,916,187 (-)Ensembl
Rnor_6.0 Ensembl99,970,209 - 9,982,295 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111590   ⟹   ENSRNOP00000089921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,904,045 - 1,916,187 (-)Ensembl
RefSeq Acc Id: NM_001126289   ⟹   NP_001119761
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,991,039 - 2,003,151 (-)NCBI
mRatBN7.291,904,044 - 1,916,156 (-)NCBI
Rnor_6.099,976,015 - 9,982,349 (+)NCBI
Rnor_5.098,975,081 - 8,981,202 (+)NCBI
Celera96,607,526 - 6,613,422 (+)RGD
Sequence:
RefSeq Acc Id: XM_039083936   ⟹   XP_038939864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,991,035 - 2,003,202 (-)NCBI
mRatBN7.291,904,040 - 1,916,207 (-)NCBI
RefSeq Acc Id: XM_039083937   ⟹   XP_038939865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,991,035 - 2,003,202 (-)NCBI
mRatBN7.291,904,040 - 1,916,207 (-)NCBI
RefSeq Acc Id: XM_039083938   ⟹   XP_038939866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,991,035 - 2,003,199 (-)NCBI
mRatBN7.291,904,040 - 1,916,202 (-)NCBI
RefSeq Acc Id: XM_039083939   ⟹   XP_038939867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,992,958 - 2,003,323 (-)NCBI
mRatBN7.291,905,963 - 1,916,325 (-)NCBI
RefSeq Acc Id: XM_063267477   ⟹   XP_063123547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,991,035 - 2,003,202 (-)NCBI
RefSeq Acc Id: XM_063267478   ⟹   XP_063123548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,991,743 - 2,003,323 (-)NCBI
RefSeq Acc Id: XM_063267479   ⟹   XP_063123549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,992,967 - 2,003,330 (-)NCBI
RefSeq Acc Id: XM_063267480   ⟹   XP_063123550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,993,174 - 2,003,318 (-)NCBI
RefSeq Acc Id: XR_005488945
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,992,978 - 2,003,318 (-)NCBI
mRatBN7.291,905,980 - 1,916,321 (-)NCBI
RefSeq Acc Id: NP_001119761   ⟸   NM_001126289
- UniProtKB: M0RBQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067003   ⟸   ENSRNOT00000075215
RefSeq Acc Id: XP_038939865   ⟸   XM_039083937
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A937 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939864   ⟸   XM_039083936
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038939866   ⟸   XM_039083938
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038939867   ⟸   XM_039083939
- Peptide Label: isoform X7
- UniProtKB: A6KQS0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000089921   ⟸   ENSRNOT00000111590
RefSeq Acc Id: XP_063123547   ⟸   XM_063267477
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063123548   ⟸   XM_063267478
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063123549   ⟸   XM_063267479
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063123550   ⟸   XM_063267480
- Peptide Label: isoform X8
Protein Domains
uDENN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RBQ8-F1-model_v2 AlphaFold M0RBQ8 1-786 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696441
Promoter ID:EPDNEW_R6964
Type:multiple initiation site
Name:Dennd1c_1
Description:DENN domain-containing protein 1C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.099,970,117 - 9,970,177EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590869 AgrOrtholog
BioCyc Gene G2FUF-28491 BioCyc
Ensembl Genes ENSRNOG00000046050 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075215 ENTREZGENE
  ENSRNOT00000075215.3 UniProtKB/TrEMBL
  ENSRNOT00000111590 ENTREZGENE
  ENSRNOT00000111590.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.450.200 UniProtKB/TrEMBL
  3.40.50.11500 UniProtKB/TrEMBL
  6.10.140.1000 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7380256 IMAGE-MGC_LOAD
InterPro dDENN UniProtKB/TrEMBL
  DENN UniProtKB/TrEMBL
  DENN_C UniProtKB/TrEMBL
  DENND1A/B/C UniProtKB/TrEMBL
  Tripartite_DENN UniProtKB/TrEMBL
  uDENN_dom UniProtKB/TrEMBL
KEGG Report rno:363326 UniProtKB/TrEMBL
MGC_CLONE MGC:187489 IMAGE-MGC_LOAD
NCBI Gene 363326 ENTREZGENE
PANTHER DENN DOMAIN-CONTAINING PROTEIN 1C UniProtKB/TrEMBL
  PTHR13196 UniProtKB/TrEMBL
Pfam dDENN UniProtKB/TrEMBL
  DENN UniProtKB/TrEMBL
  uDENN UniProtKB/TrEMBL
PhenoGen Dennd1c PhenoGen
PROSITE DENN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046050 RatGTEx
SMART dDENN UniProtKB/TrEMBL
  DENN UniProtKB/TrEMBL
  uDENN UniProtKB/TrEMBL
UniProt A0A8I6A937 ENTREZGENE, UniProtKB/TrEMBL
  A6KQS0 ENTREZGENE, UniProtKB/TrEMBL
  B1H221_RAT UniProtKB/TrEMBL
  M0RBQ8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Dennd1c  DENN domain containing 1C  Dennd1c  DENN/MADD domain containing 1C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-09-18 Dennd1c  DENN/MADD domain containing 1C  LOC363326  hypothetical LOC363326  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC363326  hypothetical LOC363326      Symbol and Name status set to provisional 70820 PROVISIONAL