Nrip2 (nuclear receptor interacting protein 2) - Rat Genome Database

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Gene: Nrip2 (nuclear receptor interacting protein 2) Rattus norvegicus
Analyze
Symbol: Nrip2
Name: nuclear receptor interacting protein 2
RGD ID: 1589959
Description: Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within Notch signaling pathway and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Orthologous to human NRIP2 (nuclear receptor interacting protein 2); INTERACTS WITH endosulfan; trichloroethene; 1,2-dichloroethane (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC689619; nuclear receptor interacting protein 2-like; nuclear receptor-interacting protein 2; similar to nuclear receptor interacting protein 2
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24161,673,964 - 161,684,055 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4161,639,356 - 161,684,070 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.04161,719,434 - 161,729,673 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4161,720,501 - 161,729,192 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04226,924,969 - 226,935,214 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44165,419,535 - 165,427,882 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4150,375,415 - 150,385,654 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10860982   PMID:23117660  


Genomics

Comparative Map Data
Nrip2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24161,673,964 - 161,684,055 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4161,639,356 - 161,684,070 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.04161,719,434 - 161,729,673 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4161,720,501 - 161,729,192 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04226,924,969 - 226,935,214 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44165,419,535 - 165,427,882 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4150,375,415 - 150,385,654 (+)NCBICelera
Cytogenetic Map4q42NCBI
NRIP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38122,825,348 - 2,835,035 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl122,825,348 - 2,835,544 (-)EnsemblGRCh38hg38GRCh38
GRCh37122,934,514 - 2,944,201 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,804,775 - 2,814,450 (-)NCBINCBI36Build 36hg18NCBI36
Build 34122,804,775 - 2,814,450NCBI
Celera124,548,450 - 4,558,161 (-)NCBICelera
Cytogenetic Map12p13.33NCBI
HuRef122,792,079 - 2,801,789 (-)NCBIHuRef
CHM1_1122,933,751 - 2,943,458 (-)NCBICHM1_1
T2T-CHM13v2.0122,831,348 - 2,841,035 (-)NCBIT2T-CHM13v2.0
Nrip2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396128,374,780 - 128,386,747 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6128,376,259 - 128,393,390 (+)EnsemblGRCm39 Ensembl
GRCm386128,397,818 - 128,409,780 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6128,399,296 - 128,416,427 (+)EnsemblGRCm38mm10GRCm38
MGSCv376128,349,784 - 128,358,953 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366128,365,385 - 128,373,870 (+)NCBIMGSCv36mm8
Celera6130,076,598 - 130,085,769 (+)NCBICelera
Cytogenetic Map6F3NCBI
NRIP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1122,877,833 - 2,888,177 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,879,690 - 2,887,722 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0122,945,844 - 2,956,155 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NRIP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12741,925,083 - 41,933,475 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2741,925,730 - 41,931,669 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha274,750,712 - 4,758,746 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02742,283,595 - 42,291,630 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2742,283,691 - 42,291,627 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12742,225,122 - 42,233,152 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02742,194,799 - 42,202,824 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0274,110,419 - 4,118,454 (-)NCBIUU_Cfam_GSD_1.0
Nrip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945106,002,501 - 106,025,116 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366063,158,910 - 3,167,578 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366063,159,049 - 3,167,629 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRIP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl567,281,107 - 67,291,522 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1567,281,032 - 67,291,524 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2569,567,779 - 69,577,827 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NRIP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1112,892,520 - 2,902,377 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl112,893,730 - 2,901,495 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660635,411,390 - 5,423,425 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Nrip2
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:310
Count of miRNA genes:208
Interacting mature miRNAs:237
Transcripts:ENSRNOT00000008196, ENSRNOT00000055886, ENSRNOT00000075182
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

Markers in Region
RH132862  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24161,683,671 - 161,683,859 (+)MAPPERmRatBN7.2
Rnor_6.04161,729,291 - 161,729,478NCBIRnor6.0
Rnor_5.04226,934,832 - 226,935,019UniSTSRnor5.0
RGSC_v3.44165,428,325 - 165,428,512UniSTSRGSC3.4
Celera4150,385,272 - 150,385,459UniSTS
RH 3.4 Map41012.5UniSTS
Cytogenetic Map4q42UniSTS
BF399280  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24161,675,753 - 161,675,934 (+)MAPPERmRatBN7.2
Rnor_6.04161,721,373 - 161,721,553NCBIRnor6.0
Rnor_5.04226,926,914 - 226,927,094UniSTSRnor5.0
RGSC_v3.44165,420,407 - 165,420,587UniSTSRGSC3.4
Celera4150,377,354 - 150,377,534UniSTS
RH 3.4 Map41012.0UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 34 6 4
Low 3 35 24 8 19 8 8 11 36 35 35 7 8
Below cutoff 8 22 22 22 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008196   ⟹   ENSRNOP00000008196
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4161,720,501 - 161,728,848 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000055886   ⟹   ENSRNOP00000052737
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4161,720,501 - 161,729,192 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105666   ⟹   ENSRNOP00000094217
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4161,639,356 - 161,684,070 (+)Ensembl
RefSeq Acc Id: XM_001071392   ⟹   XP_001071392
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24161,673,985 - 161,684,055 (+)NCBI
Rnor_6.04161,719,439 - 161,728,988 (+)NCBI
Rnor_5.04226,924,969 - 226,935,214 (+)NCBI
RGSC_v3.44165,419,535 - 165,427,882 (+)RGD
Sequence:
RefSeq Acc Id: XM_006237431   ⟹   XP_006237493
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24161,673,976 - 161,684,055 (+)NCBI
Rnor_6.04161,719,436 - 161,729,673 (+)NCBI
Rnor_5.04226,924,969 - 226,935,214 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593047   ⟹   XP_017448536
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24161,673,964 - 161,684,055 (+)NCBI
Rnor_6.04161,719,434 - 161,729,673 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_001071392 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237493 (Get FASTA)   NCBI Sequence Viewer  
  XP_017448536 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_001071392   ⟸   XM_001071392
- Peptide Label: isoform X2
- UniProtKB: D3ZPL0 (UniProtKB/TrEMBL),   A0A8I6APM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237493   ⟸   XM_006237431
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017448536   ⟸   XM_017593047
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000052737   ⟸   ENSRNOT00000055886
RefSeq Acc Id: ENSRNOP00000008196   ⟸   ENSRNOT00000008196
RefSeq Acc Id: ENSRNOP00000094217   ⟸   ENSRNOT00000105666
Protein Domains
Asp_protease

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ABB1-F1-model_v2 AlphaFold D4ABB1 1-270 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589959 AgrOrtholog
BioCyc Gene G2FUF-42860 BioCyc
Ensembl Genes ENSRNOG00000042939 Ensembl
  ENSRNOG00000063347 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000094217 ENTREZGENE
  ENSRNOP00000094217.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000105666 ENTREZGENE
  ENSRNOT00000105666.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.70.10 UniProtKB/TrEMBL
InterPro Peptidase_aspartic_DDI1-type UniProtKB/TrEMBL
  Peptidase_aspartic_dom_sf UniProtKB/TrEMBL
NCBI Gene 689619 ENTREZGENE
Pfam Asp_protease UniProtKB/TrEMBL
PhenoGen Nrip2 PhenoGen
Superfamily-SCOP SSF50630 UniProtKB/TrEMBL
UniProt A0A8I6APM8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZPL0 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Nrip2  nuclear receptor interacting protein 2  Nrip2  nuclear receptor interacting protein 2  Data Merged 737654 PROVISIONAL
2021-08-09 Nrip2  nuclear receptor interacting protein 2      Symbol and Name status set to provisional 45752 PROVISIONAL
2013-05-24 Nrip2  nuclear receptor interacting protein 2  LOC100364151  nuclear receptor interacting protein 2-like  Data Merged 1643240 APPROVED
2012-10-02 Nrip2  nuclear receptor interacting protein 2  LOC689619  similar to nuclear receptor interacting protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100364151  nuclear receptor interacting protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-01-09 LOC689619  similar to nuclear receptor interacting protein 2  LOC683559  similar to nuclear receptor interacting protein 2  Data Merged 1643240 APPROVED
2006-11-20 LOC689619  similar to nuclear receptor interacting protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC683559  similar to nuclear receptor interacting protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL