Plin5 (perilipin 5) - Rat Genome Database

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Gene: Plin5 (perilipin 5) Rattus norvegicus
Analyze
Symbol: Plin5
Name: perilipin 5
RGD ID: 1589602
Description: Enables lipase binding activity. Involved in positive regulation of fatty acid beta-oxidation and positive regulation of sequestering of triglyceride. Located in lipid droplet and mitochondrion. Orthologous to human PLIN5 (perilipin 5); INTERACTS WITH 1-naphthyl isothiocyanate; 3,3',5,5'-tetrabromobisphenol A; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: lipid storage droplet protein 5; LOC501283; Oxpat; perilipin-5; similar to lipid droplet associated protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,026,910 - 1,033,352 (-)NCBIGRCr8
mRatBN7.29939,745 - 946,188 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9939,747 - 946,120 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx91,386,151 - 1,392,516 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.096,733,424 - 6,739,795 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.095,691,188 - 5,697,553 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,956,013 - 10,961,782 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,956,056 - 10,961,782 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,943,003 - 9,948,729 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera97,561,527 - 7,567,886 (+)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cantharidin  (ISO)
carbon nanotube  (ISO)
clofibrate  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diquat  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
fenofibrate  (EXP)
genistein  (ISO)
hexadecanoic acid  (EXP)
indometacin  (ISO)
inulin  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
Mesaconitine  (EXP)
methidathion  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
oleic acid  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
propiconazole  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity. Bosma M, etal., Biochim Biophys Acta. 2013 Apr;1831(4):844-52. doi: 10.1016/j.bbalip.2013.01.007. Epub 2013 Jan 22.
2. The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria. Bosma M, etal., Histochem Cell Biol. 2012 Feb;137(2):205-16. doi: 10.1007/s00418-011-0888-x. Epub 2011 Nov 30.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contraction. MacPherson RE, etal., Am J Physiol Regul Integr Comp Physiol. 2013 Apr 15;304(8):R644-50. doi: 10.1152/ajpregu.00418.2012. Epub 2013 Feb 13.
5. Skeletal muscle PLIN3 and PLIN5 are serine phosphorylated at rest and following lipolysis during adrenergic or contractile stimulation. Macpherson RE, etal., Physiol Rep. 2013 Sep;1(4):e00084. doi: 10.1002/phy2.84. Epub 2013 Sep 17.
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria. Wang H, etal., J Lipid Res. 2011 Dec;52(12):2159-68. doi: 10.1194/jlr.M017939. Epub 2011 Aug 31.
Additional References at PubMed
PMID:16571721   PMID:17130488   PMID:19717842   PMID:20198297   PMID:21148142   PMID:22532565   PMID:22675471   PMID:23345411   PMID:25552350   PMID:25804837   PMID:32296390  


Genomics

Comparative Map Data
Plin5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,026,910 - 1,033,352 (-)NCBIGRCr8
mRatBN7.29939,745 - 946,188 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9939,747 - 946,120 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx91,386,151 - 1,392,516 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.096,733,424 - 6,739,795 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.095,691,188 - 5,697,553 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,956,013 - 10,961,782 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,956,056 - 10,961,782 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,943,003 - 9,948,729 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera97,561,527 - 7,567,886 (+)NCBICelera
Cytogenetic Map9q11NCBI
PLIN5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,522,531 - 4,535,224 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,522,531 - 4,535,224 (-)EnsemblGRCh38hg38GRCh38
GRCh37194,522,543 - 4,535,236 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,473,543 - 4,486,208 (-)NCBINCBI36Build 36hg18NCBI36
Celera194,461,329 - 4,473,994 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef194,284,194 - 4,296,925 (-)NCBIHuRef
CHM1_1194,522,721 - 4,535,399 (-)NCBICHM1_1
T2T-CHM13v2.0194,506,212 - 4,518,891 (-)NCBIT2T-CHM13v2.0
Plin5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391756,418,601 - 56,424,606 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1756,418,601 - 56,424,596 (-)EnsemblGRCm39 Ensembl
GRCm381756,111,597 - 56,117,606 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,111,601 - 56,117,596 (-)EnsemblGRCm38mm10GRCm38
MGSCv371756,251,024 - 56,256,971 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361755,704,894 - 55,710,821 (-)NCBIMGSCv36mm8
Celera1759,530,262 - 59,536,209 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.16NCBI
Plin5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,407,246 - 4,416,848 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554954,406,590 - 4,414,783 (+)NCBIChiLan1.0ChiLan1.0
PLIN5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2208,917,017 - 8,929,816 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1198,146,807 - 8,159,602 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,542,675 - 3,555,611 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,496,475 - 4,502,936 (-)NCBIpanpan1.1PanPan1.1panPan2
PLIN5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,181,171 - 55,189,369 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,181,198 - 55,189,366 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2054,909,690 - 54,917,493 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02055,839,605 - 55,847,423 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2055,839,463 - 55,847,422 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12054,901,592 - 54,909,392 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,382,123 - 55,389,929 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,580,396 - 55,588,202 (+)NCBIUU_Cfam_GSD_1.0
Plin5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,197,457 - 215,205,026 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,629,762 - 2,636,983 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365882,629,762 - 2,637,303 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLIN5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,300,619 - 74,314,315 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,304,613 - 74,314,314 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2274,797,979 - 74,806,072 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLIN5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.164,251,316 - 4,262,656 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl64,251,751 - 4,261,126 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660813,928,417 - 3,940,329 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plin5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,207,937 - 5,218,901 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,208,060 - 5,218,553 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Plin5
19 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:258
Count of miRNA genes:170
Interacting mature miRNAs:190
Transcripts:ENSRNOT00000073930
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat

Markers in Region
RH140736  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29940,003 - 940,148 (-)MAPPERmRatBN7.2
Rnor_6.0910,961,382 - 10,961,526NCBIRnor6.0
Rnor_5.099,948,329 - 9,948,473UniSTSRnor5.0
Celera97,567,486 - 7,567,630UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 6 3 3 5 3
Low 8 35 25 6 25 5 6 20 21 21 11 5
Below cutoff 2 2 6 6 10 6 38 2 9

Sequence


RefSeq Acc Id: ENSRNOT00000073930   ⟹   ENSRNOP00000065588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9939,747 - 946,120 (-)Ensembl
Rnor_6.0 Ensembl910,956,056 - 10,961,782 (+)Ensembl
RefSeq Acc Id: NM_001134637   ⟹   NP_001128109
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,026,912 - 1,033,284 (-)NCBI
mRatBN7.29939,747 - 946,120 (-)NCBI
Rnor_6.0910,956,056 - 10,961,782 (+)NCBI
Rnor_5.099,943,003 - 9,948,729 (+)NCBI
Celera97,561,527 - 7,567,886 (+)RGD
Sequence:
RefSeq Acc Id: XM_039084129   ⟹   XP_038940057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,026,910 - 1,033,070 (-)NCBI
mRatBN7.29939,745 - 945,909 (-)NCBI
RefSeq Acc Id: XM_039084130   ⟹   XP_038940058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,026,910 - 1,033,352 (-)NCBI
mRatBN7.29939,745 - 946,187 (-)NCBI
RefSeq Acc Id: XM_039084131   ⟹   XP_038940059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,026,910 - 1,033,352 (-)NCBI
mRatBN7.29939,745 - 946,188 (-)NCBI
RefSeq Acc Id: NP_001128109   ⟸   NM_001134637
- UniProtKB: M0R7Z9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065588   ⟸   ENSRNOT00000073930
RefSeq Acc Id: XP_038940059   ⟸   XM_039084131
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038940058   ⟸   XM_039084130
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038940057   ⟸   XM_039084129
- Peptide Label: isoform X1
- UniProtKB: M0R7Z9 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R7Z9-F1-model_v2 AlphaFold M0R7Z9 1-475 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696468
Promoter ID:EPDNEW_R6993
Type:initiation region
Name:Plin5_1
Description:perilipin 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0910,956,061 - 10,956,121EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589602 AgrOrtholog
BioCyc Gene G2FUF-28562 BioCyc
Ensembl Genes ENSRNOG00000047860 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055015060 UniProtKB/Swiss-Prot
  ENSRNOG00060018792 UniProtKB/Swiss-Prot
  ENSRNOG00065013545 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073930 ENTREZGENE
  ENSRNOT00000073930.2 UniProtKB/Swiss-Prot
  ENSRNOT00055025754 UniProtKB/Swiss-Prot
  ENSRNOT00060032386 UniProtKB/Swiss-Prot
  ENSRNOT00065022265 UniProtKB/Swiss-Prot
Gene3D-CATH Flagellar protein FliS UniProtKB/Swiss-Prot
  Perilipin, alpha-beta domain UniProtKB/Swiss-Prot
InterPro Perilipin UniProtKB/Swiss-Prot
KEGG Report rno:501283 UniProtKB/Swiss-Prot
NCBI Gene 501283 ENTREZGENE
PANTHER PERILIPIN UniProtKB/Swiss-Prot
  PERILIPIN-5 UniProtKB/Swiss-Prot
Pfam Perilipin UniProtKB/Swiss-Prot
PhenoGen Plin5 PhenoGen
PIRSF PAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000047860 RatGTEx
  ENSRNOG00055015060 RatGTEx
  ENSRNOG00060018792 RatGTEx
  ENSRNOG00065013545 RatGTEx
Superfamily-SCOP Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain UniProtKB/Swiss-Prot
UniProt M0R7Z9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-02-12 Plin5  perilipin 5  LOC501283  similar to lipid droplet associated protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC501283  similar to lipid droplet associated protein      Symbol and Name status set to provisional 70820 PROVISIONAL