Mllt1 (MLLT1, super elongation complex subunit) - Rat Genome Database

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Gene: Mllt1 (MLLT1, super elongation complex subunit) Rattus norvegicus
Analyze
Symbol: Mllt1
Name: MLLT1, super elongation complex subunit
RGD ID: 1588581
Description: Predicted to enable chromatin binding activity and lysine-acetylated histone binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be part of transcription elongation factor complex. Orthologous to human MLLT1 (MLLT1 super elongation complex subunit); PARTICIPATES IN RNA polymerase II transcription elongation pathway; INTERACTS WITH bisphenol A; 1,2-dimethylhydrazine (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC301119; myeloid/lymphoid or mixed lineage leukemia translocation to 1 homolog; myeloid/lymphoid or mixed lineage leukemia translocation to 1 homolog (Drosophila); myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog; myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); protein ENL; similar to myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog; translocated to, 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.291,731,077 - 1,775,985 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,731,080 - 1,775,970 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,164,990 - 2,209,816 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,514,684 - 7,559,510 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,470,184 - 6,515,010 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,110,389 - 10,155,305 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,110,389 - 10,155,302 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,110,342 - 9,154,498 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,741,249 - 6,786,040 (+)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The super elongation complex (SEC) family in transcriptional control. Luo Z, etal., Nat Rev Mol Cell Biol. 2012 Sep;13(9):543-7. doi: 10.1038/nrm3417. Epub 2012 Aug 16.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:11007757   PMID:22195968  


Genomics

Comparative Map Data
Mllt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.291,731,077 - 1,775,985 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,731,080 - 1,775,970 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,164,990 - 2,209,816 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,514,684 - 7,559,510 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,470,184 - 6,515,010 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,110,389 - 10,155,305 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,110,389 - 10,155,302 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,110,342 - 9,154,498 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,741,249 - 6,786,040 (+)NCBICelera
Cytogenetic Map9q11NCBI
MLLT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,210,381 - 6,279,975 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,210,381 - 6,279,975 (-)EnsemblGRCh38hg38GRCh38
GRCh37196,210,392 - 6,279,986 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,161,392 - 6,230,959 (-)NCBINCBI36Build 36hg18NCBI36
Build 34196,163,965 - 6,230,959NCBI
Celera196,149,173 - 6,218,734 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef195,969,364 - 6,038,974 (-)NCBIHuRef
CHM1_1196,209,972 - 6,279,567 (-)NCBICHM1_1
T2T-CHM13v2.0196,198,560 - 6,268,171 (-)NCBIT2T-CHM13v2.0
Mllt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,199,611 - 57,242,497 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,199,611 - 57,242,415 (-)EnsemblGRCm39 Ensembl
GRCm381756,892,608 - 56,935,509 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,892,611 - 56,935,415 (-)EnsemblGRCm38mm10GRCm38
MGSCv371757,032,034 - 57,074,811 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,577,735 - 56,620,512 (-)NCBIMGSCv36mm8
Celera1761,237,292 - 61,280,070 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.56NCBI
Mllt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,289,641 - 3,336,509 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554953,289,644 - 3,336,455 (+)NCBIChiLan1.0ChiLan1.0
MLLT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1199,837,231 - 9,906,921 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0195,231,481 - 5,301,160 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1196,156,365 - 6,224,043 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,156,365 - 6,216,779 (-)Ensemblpanpan1.1panPan2
MLLT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,844,972 - 53,913,753 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,779,802 - 53,913,651 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,592,802 - 53,659,964 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02054,500,058 - 54,567,226 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,500,058 - 54,570,642 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,566,637 - 53,633,779 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02054,015,551 - 54,082,695 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,245,032 - 54,312,120 (+)NCBIUU_Cfam_GSD_1.0
Mllt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,156,251 - 214,213,547 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,619,493 - 3,669,854 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365883,619,480 - 3,678,532 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MLLT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,781,121 - 72,847,685 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1272,780,950 - 72,847,694 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2273,345,660 - 73,409,227 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MLLT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.165,835,483 - 5,913,096 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl65,834,660 - 5,913,119 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660812,116,213 - 2,194,227 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mllt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248284,093,502 - 4,110,350 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248284,055,244 - 4,110,246 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mllt1
136 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:329
Count of miRNA genes:183
Interacting mature miRNAs:225
Transcripts:ENSRNOT00000071211
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat

Markers in Region
RH125746  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,731,137 - 1,731,387 (-)MAPPERmRatBN7.2
Rnor_6.0910,154,995 - 10,155,244NCBIRnor6.0
Rnor_5.099,154,191 - 9,154,440UniSTSRnor5.0
Celera96,785,733 - 6,785,982UniSTS
Cytogenetic Map9q11UniSTS
RH124646  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,731,249 - 1,731,436 (-)MAPPERmRatBN7.2
Rnor_6.0910,154,946 - 10,155,132NCBIRnor6.0
Rnor_5.099,154,142 - 9,154,328UniSTSRnor5.0
Celera96,785,684 - 6,785,870UniSTS
Cytogenetic Map9q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 33 24 17 24 2 74 29 40 11
Low 9 24 17 2 17 8 9 6 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000071211   ⟹   ENSRNOP00000064141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,731,080 - 1,775,970 (-)Ensembl
Rnor_6.0 Ensembl910,110,389 - 10,155,302 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109046   ⟹   ENSRNOP00000092239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,731,080 - 1,775,970 (-)Ensembl
RefSeq Acc Id: NM_001106876   ⟹   NP_001100346
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.291,731,080 - 1,775,970 (-)NCBI
Rnor_6.0910,110,389 - 10,155,302 (+)NCBI
Rnor_5.099,110,342 - 9,154,498 (+)NCBI
Celera96,741,249 - 6,786,040 (+)RGD
Sequence:
RefSeq Acc Id: XM_006244307   ⟹   XP_006244369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.291,731,077 - 1,775,985 (-)NCBI
Rnor_6.0910,110,394 - 10,155,305 (+)NCBI
Rnor_5.099,110,342 - 9,154,498 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083136   ⟹   XP_038939064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.291,731,077 - 1,767,239 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100346 (Get FASTA)   NCBI Sequence Viewer  
  XP_006244369 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939064 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83599 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064141
  ENSRNOP00000064141.2
  ENSRNOP00000092239
  ENSRNOP00000092239.1
Reference Protein Sequences
RefSeq Acc Id: NP_001100346   ⟸   NM_001106876
- UniProtKB: M0R462 (UniProtKB/TrEMBL),   A6KQU1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244369   ⟸   XM_006244307
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AH62 (UniProtKB/TrEMBL),   M0R462 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064141   ⟸   ENSRNOT00000071211
RefSeq Acc Id: XP_038939064   ⟸   XM_039083136
- Peptide Label: isoform X2
- UniProtKB: M0R462 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000092239   ⟸   ENSRNOT00000109046
Protein Domains
AF-9 ANC1 homology

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R462-F1-model_v2 AlphaFold M0R462 1-547 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696447
Promoter ID:EPDNEW_R6972
Type:initiation region
Name:Mllt1_1
Description:MLLT1, super elongation complex subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0910,110,432 - 10,110,492EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588581 AgrOrtholog
BioCyc Gene G2FUF-28505 BioCyc
Ensembl Genes ENSRNOG00000048736 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071211 ENTREZGENE
  ENSRNOT00000071211.2 UniProtKB/TrEMBL
  ENSRNOT00000109046 ENTREZGENE
  ENSRNOT00000109046.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.290 UniProtKB/TrEMBL
  2.60.40.1970 UniProtKB/TrEMBL
InterPro AF-9_AHD UniProtKB/TrEMBL
  YEAST_sf UniProtKB/TrEMBL
  YEATS UniProtKB/TrEMBL
KEGG Report rno:301119 UniProtKB/TrEMBL
NCBI Gene 301119 ENTREZGENE
PANTHER AHD DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  PROTEIN ENL UniProtKB/TrEMBL
Pfam AHD UniProtKB/TrEMBL
  YEATS UniProtKB/TrEMBL
PhenoGen Mllt1 PhenoGen
PROSITE YEATS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048736 RatGTEx
UniProt A0A8I6AH62 ENTREZGENE, UniProtKB/TrEMBL
  A6KQU1 ENTREZGENE, UniProtKB/TrEMBL
  M0R462 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-22 Mllt1  MLLT1, super elongation complex subunit  Mllt1  myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-01 Mllt1  myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1  Mllt1  myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-14 Mllt1  myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1  Mllt1  myeloid/lymphoid or mixed lineage leukemia translocation to 1 homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Mllt1  myeloid/lymphoid or mixed lineage leukemia translocation to 1 homolog (Drosophila)  LOC301119  similar to myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC301119  similar to myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL