Spx (spexin hormone) - Rat Genome Database

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Gene: Spx (spexin hormone) Rattus norvegicus
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Symbol: Spx
Name: spexin hormone
RGD ID: 1587448
Description: Predicted to enable neuropeptide hormone activity; type 2 galanin receptor binding activity; and type 3 galanin receptor binding activity. Involved in several processes, including long-chain fatty acid import into cell; negative regulation of appetite; and negative regulation of renal sodium excretion. Located in cytoplasm. Orthologous to human SPX (spexin hormone); INTERACTS WITH 17beta-estradiol; bisphenol A; testosterone.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC691138; liver regeneration-related protein LRRGT00060; LOC691138; LRRGT00060; neuropeptide Q; Npq; spexin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24175,356,044 - 175,362,082 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,356,247 - 175,362,082 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4181,650,891 - 181,656,929 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04177,435,164 - 177,441,200 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04176,055,727 - 176,061,763 (+)NCBIRnor_WKY
Rnor_6.04176,629,597 - 176,635,698 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,629,800 - 176,641,008 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04240,843,758 - 240,849,264 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44179,975,336 - 179,980,842 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4163,888,558 - 163,894,628 (+)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA)
dense core granule  (ISO,ISS)
extracellular space  (IBA,ISO,ISS)
transport vesicle  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Identification of novel peptide hormones in the human proteome by hidden Markov model screening. Mirabeau O, etal., Genome Res. 2007 Mar;17(3):320-7. Epub 2007 Feb 6.
3. Spexin expression in normal rat tissues. Porzionato A, etal., J Histochem Cytochem. 2010 Sep;58(9):825-37. doi: 10.1369/jhc.2010.956300. Epub 2010 Jun 7.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception. Toll L, etal., FASEB J. 2012 Feb;26(2):947-54. doi: 10.1096/fj.11-192831. Epub 2011 Oct 28.
6. Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity. Walewski JL, etal., Obesity (Silver Spring). 2014 Jul;22(7):1643-52. doi: 10.1002/oby.20725. Epub 2014 Mar 8.
Additional References at PubMed
PMID:19193193   PMID:20045034   PMID:23080164   PMID:24517231   PMID:31396649   PMID:33928538  


Genomics

Comparative Map Data
Spx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24175,356,044 - 175,362,082 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,356,247 - 175,362,082 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4181,650,891 - 181,656,929 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04177,435,164 - 177,441,200 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04176,055,727 - 176,061,763 (+)NCBIRnor_WKY
Rnor_6.04176,629,597 - 176,635,698 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,629,800 - 176,641,008 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04240,843,758 - 240,849,264 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44179,975,336 - 179,980,842 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4163,888,558 - 163,894,628 (+)NCBICelera
Cytogenetic Map4q44NCBI
SPX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381221,526,296 - 21,532,947 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1221,526,296 - 21,541,249 (+)EnsemblGRCh38hg38GRCh38
GRCh371221,679,230 - 21,685,881 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,570,523 - 21,575,477 (+)NCBINCBI36Build 36hg18NCBI36
Celera1226,834,644 - 26,839,598 (+)NCBICelera
Cytogenetic Map12p12.1NCBI
HuRef1221,453,255 - 21,458,209 (+)NCBIHuRef
CHM1_11221,644,862 - 21,649,814 (+)NCBICHM1_1
T2T-CHM13v2.01221,405,263 - 21,411,916 (+)NCBIT2T-CHM13v2.0
Spx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396142,359,114 - 142,365,466 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6142,359,167 - 142,365,456 (+)EnsemblGRCm39 Ensembl
GRCm386142,413,388 - 142,419,740 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6142,413,441 - 142,419,730 (+)EnsemblGRCm38mm10GRCm38
MGSCv376142,361,961 - 142,367,091 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366142,371,234 - 142,376,962 (+)NCBIMGSCv36mm8
Celera6145,473,941 - 145,479,073 (+)NCBICelera
Cytogenetic Map6G2NCBI
Spx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541317,173,215 - 17,178,388 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541317,173,215 - 17,178,388 (+)NCBIChiLan1.0ChiLan1.0
SPX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11267,369,413 - 67,375,680 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1267,369,413 - 67,375,630 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01264,766,136 - 64,771,728 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SPX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12725,561,636 - 25,572,310 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2725,563,606 - 25,571,093 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2720,780,749 - 20,789,452 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02725,791,296 - 25,799,202 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2725,792,502 - 25,818,889 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12725,584,197 - 25,592,099 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02725,604,663 - 25,615,317 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02720,957,128 - 20,965,827 (+)NCBIUU_Cfam_GSD_1.0
SPX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl551,920,400 - 51,941,598 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1551,919,474 - 51,929,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2555,196,569 - 55,205,161 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11121,391,660 - 21,401,860 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1121,392,621 - 21,396,923 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606913,746,535 - 13,757,244 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475217,147,925 - 17,152,430 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475217,146,644 - 17,154,855 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spx
47 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium
Low 2 2 2 14
Below cutoff 2 12 8 3 8 25 6 12 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000086529   ⟹   ENSRNOP00000068862
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4176,629,975 - 176,641,008 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087378   ⟹   ENSRNOP00000071461
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4175,356,247 - 175,362,082 (+)Ensembl
Rnor_6.0 Ensembl4176,629,800 - 176,634,504 (+)Ensembl
RefSeq Acc Id: NM_001083933   ⟹   NP_001077402
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24175,356,044 - 175,362,082 (+)NCBI
Rnor_6.04176,629,597 - 176,635,698 (+)NCBI
Rnor_5.04240,843,758 - 240,849,264 (+)NCBI
RGSC_v3.44179,975,336 - 179,980,842 (+)RGD
Celera4163,888,558 - 163,894,628 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001077402 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ96273 (Get FASTA)   NCBI Sequence Viewer  
  M0R8L2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001077402   ⟸   NM_001083933
- Peptide Label: precursor
- UniProtKB: Q6TXE0 (UniProtKB/Swiss-Prot),   M0R8L2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071461   ⟸   ENSRNOT00000087378
RefSeq Acc Id: ENSRNOP00000068862   ⟸   ENSRNOT00000086529

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R8L2-F1-model_v2 AlphaFold M0R8L2 1-116 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587448 AgrOrtholog
BioCyc Gene G2FUF-42493 BioCyc
Ensembl Genes ENSRNOG00000053700 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000071461 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000087378 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Spexin UniProtKB/Swiss-Prot
KEGG Report rno:691138 UniProtKB/Swiss-Prot
NCBI Gene 691138 ENTREZGENE
PANTHER PTHR28590 UniProtKB/Swiss-Prot
Pfam Spexin UniProtKB/Swiss-Prot
PhenoGen Spx PhenoGen
UniProt M0R8L2 ENTREZGENE
  Q6TXE0 ENTREZGENE
  SPXN_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q6TXE0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-23 Spx  spexin hormone  LOC691138  hypothetical protein LOC691138  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 LOC691138  hypothetical protein LOC691138  LOC686427  hypothetical protein LOC686427  Data Merged 1643240 APPROVED
2006-11-20 LOC686427  hypothetical protein LOC686427      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC691138  hypothetical protein LOC691138      Symbol and Name status set to provisional 70820 PROVISIONAL