Plp2 (proteolipid protein 2) - Rat Genome Database

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Gene: Plp2 (proteolipid protein 2) Rattus norvegicus
Analyze
Symbol: Plp2
Name: proteolipid protein 2
RGD ID: 1587363
Description: Predicted to enable chemokine binding activity. Predicted to be located in plasma membrane. Orthologous to human PLP2 (proteolipid protein 2); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: A4-LSB; Plp2_mapped; proteolipid protein 2 (colonic epithelium-enriched); Proteolipid protein 2 (intestinal membrane A4 protein); proteolipid protein 2 (mapped)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,506,153 - 17,509,552 (+)NCBIGRCr8
mRatBN7.2X14,834,249 - 14,837,648 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,834,231 - 14,838,514 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,648,391 - 19,651,794 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,431,338 - 20,434,740 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,696,481 - 16,699,885 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,679,254 - 15,682,653 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,679,254 - 15,682,652 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,470,480 - 16,473,879 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,875,110 - 26,878,509 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX14,917,582 - 14,920,981 (+)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deguelin  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
entinostat  (ISO)
fenoldopam  (EXP)
finasteride  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
indole-3-methanol  (EXP)
L-methionine  (ISO)
levofloxacin  (EXP)
methotrexate  (ISO)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
potassium dichromate  (ISO)
pyrogallol  (ISO)
resveratrol  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (EXP)
triphenyl phosphate  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15474493   PMID:15489334   PMID:23376485  


Genomics

Comparative Map Data
Plp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,506,153 - 17,509,552 (+)NCBIGRCr8
mRatBN7.2X14,834,249 - 14,837,648 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,834,231 - 14,838,514 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,648,391 - 19,651,794 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,431,338 - 20,434,740 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,696,481 - 16,699,885 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,679,254 - 15,682,653 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,679,254 - 15,682,652 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,470,480 - 16,473,879 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,875,110 - 26,878,509 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX14,917,582 - 14,920,981 (+)NCBICelera
Cytogenetic MapXq12NCBI
PLP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X49,171,898 - 49,175,235 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX49,171,898 - 49,175,235 (+)EnsemblGRCh38hg38GRCh38
GRCh37X49,028,245 - 49,031,584 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,915,217 - 48,918,382 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X48,784,643 - 48,787,808NCBI
CeleraX52,632,900 - 52,636,185 (-)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,685,454 - 46,688,739 (+)NCBIHuRef
CHM1_1X49,060,509 - 49,063,794 (+)NCBICHM1_1
T2T-CHM13v2.0X48,583,646 - 48,586,985 (+)NCBIT2T-CHM13v2.0
Plp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,534,180 - 7,537,629 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,534,180 - 7,537,629 (-)EnsemblGRCm39 Ensembl
GRCm38X7,667,941 - 7,671,390 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,667,941 - 7,671,390 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X7,245,242 - 7,248,404 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X6,824,905 - 6,828,291 (-)NCBIMGSCv36mm8
CeleraX3,799,548 - 3,802,789 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.45NCBI
Plp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955543658,486 - 662,441 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955543658,617 - 662,441 (+)NCBIChiLan1.0ChiLan1.0
PLP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X50,662,887 - 50,666,708 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X50,664,236 - 50,670,087 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X41,473,985 - 41,474,882 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X49,324,184 - 49,327,463 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX49,324,176 - 49,328,698 (+)Ensemblpanpan1.1panPan2
LOC480914
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X42,273,463 - 42,276,206 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX42,273,806 - 42,276,242 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,652,212 - 16,655,336 (+)NCBIDog10K_Boxer_Tasha
Plp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,806,869 - 34,810,258 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367211,042,171 - 1,050,661 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367211,047,261 - 1,050,647 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX43,215,283 - 43,218,316 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X43,215,372 - 43,218,318 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X48,063,314 - 48,066,260 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X46,267,194 - 46,270,538 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607611,832,254 - 11,835,969 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624893913,105 - 916,282 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624893913,106 - 916,263 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Plp2
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:173
Count of miRNA genes:128
Interacting mature miRNAs:154
Transcripts:ENSRNOT00000045256
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat

Markers in Region
RH130016  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,832,270 - 14,832,460 (+)MAPPERmRatBN7.2
Rnor_6.0X15,677,276 - 15,677,465NCBIRnor6.0
Rnor_5.0X16,468,502 - 16,468,691UniSTSRnor5.0
RGSC_v3.4X26,873,132 - 26,873,321UniSTSRGSC3.4
CeleraX14,915,604 - 14,915,793UniSTS
RH 3.4 MapX157.8UniSTS
Cytogenetic MapXq13UniSTS
RH136577  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0X16,473,541 - 16,473,725NCBIRnor5.0
Rnor_5.04188,532,081 - 188,532,265NCBIRnor5.0
Rnor_5.04188,475,121 - 188,475,305NCBIRnor5.0
RGSC_v3.4X26,878,172 - 26,878,355UniSTSRGSC3.4
RGSC_v3.44127,132,356 - 127,132,539UniSTSRGSC3.4
CeleraX14,920,644 - 14,920,827UniSTS
Celera4114,311,849 - 114,312,032UniSTS
Cytogenetic MapXq13UniSTS
Cytogenetic Map4q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 40 26 19 26 2 5 31 32 34 11 2
Low 7 17 15 15 6 6 43 3 7 6
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000045256   ⟹   ENSRNOP00000039462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,834,250 - 14,837,632 (+)Ensembl
Rnor_6.0 EnsemblX15,679,254 - 15,682,652 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098875   ⟹   ENSRNOP00000077879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,834,231 - 14,838,514 (+)Ensembl
RefSeq Acc Id: NM_207601   ⟹   NP_997484
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X17,506,153 - 17,509,552 (+)NCBI
mRatBN7.2X14,834,249 - 14,837,648 (+)NCBI
Rnor_6.0X15,679,254 - 15,682,653 (+)NCBI
Rnor_5.0X16,470,480 - 16,473,879 (+)NCBI
RGSC_v3.4X26,875,110 - 26,878,509 (+)RGD
CeleraX14,917,582 - 14,920,981 (+)RGD
Sequence:
RefSeq Acc Id: NP_997484   ⟸   NM_207601
- UniProtKB: Q6P742 (UniProtKB/Swiss-Prot),   A6KP90 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000039462   ⟸   ENSRNOT00000045256
RefSeq Acc Id: ENSRNOP00000077879   ⟸   ENSRNOT00000098875
Protein Domains
MARVEL

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P742-F1-model_v2 AlphaFold Q6P742 1-151 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701747
Promoter ID:EPDNEW_R12271
Type:initiation region
Name:Plp2_1
Description:proteolipid protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X15,679,233 - 15,679,293EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587363 AgrOrtholog
BioCyc Gene G2FUF-2911 BioCyc
Ensembl Genes ENSRNOG00000039496 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055027783 UniProtKB/Swiss-Prot
  ENSRNOG00060029971 UniProtKB/Swiss-Prot
  ENSRNOG00065011202 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000045256.4 UniProtKB/TrEMBL
  ENSRNOT00000098875.1 UniProtKB/TrEMBL
  ENSRNOT00055048117 UniProtKB/Swiss-Prot
  ENSRNOT00060052072 UniProtKB/Swiss-Prot
  ENSRNOT00065018134 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5621135 IMAGE-MGC_LOAD
InterPro Marvel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:302562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72557 IMAGE-MGC_LOAD
NCBI Gene 302562 ENTREZGENE
PANTHER MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEOLIPID PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MARVEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plp2 PhenoGen
PROSITE MARVEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039496 RatGTEx
  ENSRNOG00055027783 RatGTEx
  ENSRNOG00060029971 RatGTEx
  ENSRNOG00065011202 RatGTEx
UniProt A0A8I5Y253_RAT UniProtKB/TrEMBL
  A0A8L2QJL6_RAT UniProtKB/TrEMBL
  A6KP90 ENTREZGENE, UniProtKB/TrEMBL
  A6KP91_RAT UniProtKB/TrEMBL
  A6KP92_RAT UniProtKB/TrEMBL
  PLP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-10 Plp2  proteolipid protein 2  Plp2  proteolipid protein 2 (colonic epithelium-enriched)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Plp2  proteolipid protein 2 (colonic epithelium-enriched)  Plp2  proteolipid protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   proteolipid protein 2  Plp2  proteolipid protein 2 (mapped)  Name updated 737654 APPROVED
2007-04-11 Plp2  proteolipid protein 2 (mapped)  Plp2_mapped  proteolipid protein 2 (mapped)  Data merged from RGD:3355 737654 APPROVED
2006-11-19 Plp2  proteolipid protein 2 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Plp2_mapped  proteolipid protein 2 (mapped)  Plp2  proteolipid protein 2  Symbol and Name updated 1556543 APPROVED
2002-06-10 Plp2  Proteolipid protein 2 (intestinal membrane A4 protein)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology mouse homologue Plp2 penetrates at least one phospholipid bilayer of membranes 737860