Higd2al1 (HIG1 hypoxia inducible domain family, member 2A-like 1) - Rat Genome Database

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Gene: Higd2al1 (HIG1 hypoxia inducible domain family, member 2A-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Higd2al1
Name: HIG1 hypoxia inducible domain family, member 2A-like 1
RGD ID: 1586494
Description: Predicted to be located in membrane. Orthologous to several human genes including HIGD2A (HIG1 hypoxia inducible domain family member 2A); INTERACTS WITH bis(2-ethylhexyl) phthalate; bisphenol A; dibutyl phthalate.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: HIG1 domain family member 2A-like; LOC688606; similar to HIG1 domain family, member 2A
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8127,574,795 - 7,575,432 (-)NCBIGRCr8
mRatBN7.2122,777,094 - 2,777,581 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,777,231 - 2,777,551 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0124,546,240 - 4,546,871 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0126,674,297 - 6,674,802 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,366,296 - 1,366,616 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera124,591,942 - 4,592,572 (-)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:19
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000001416
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)127977298525593Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat

Markers in Region
RH133064  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2122,777,024 - 2,777,234 (-)MAPPERmRatBN7.2
mRatBN7.21710,021,906 - 10,022,116 (+)MAPPERmRatBN7.2
Rnor_6.01710,558,768 - 10,558,977NCBIRnor6.0
Rnor_6.0124,546,604 - 4,546,813NCBIRnor6.0
Rnor_5.01712,684,766 - 12,684,975UniSTSRnor5.0
Rnor_5.0126,674,667 - 6,674,876UniSTSRnor5.0
RGSC_v3.41716,083,907 - 16,084,116UniSTSRGSC3.4
RGSC_v3.4121,366,613 - 1,366,822UniSTSRGSC3.4
Celera124,592,000 - 4,592,209UniSTS
Celera1710,094,872 - 10,095,081UniSTS
Cytogenetic Map12p12UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000001416   ⟹   ENSRNOP00000001416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl122,777,231 - 2,777,551 (-)Ensembl
RefSeq Acc Id: XM_039089911   ⟹   XP_038945839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8127,574,795 - 7,575,432 (-)NCBI
mRatBN7.2122,777,094 - 2,777,581 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038945839 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001416.1
RefSeq Acc Id: XP_038945839   ⟸   XM_039089911
- UniProtKB: D3ZU87 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000001416   ⟸   ENSRNOT00000001416
Protein Domains
HIG1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZU87-F1-model_v2 AlphaFold D3ZU87 1-106 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586494 AgrOrtholog
BioCyc Gene G2FUF-20338 BioCyc
Ensembl Genes ENSRNOG00000001071 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001416.3 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.1320 UniProtKB/TrEMBL
InterPro Hypoxia_induced_domain UniProtKB/TrEMBL
  RCF1 UniProtKB/TrEMBL
NCBI Gene 688606 ENTREZGENE
PANTHER HIG1 DOMAIN FAMILY MEMBER 2A UniProtKB/TrEMBL
  HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED UniProtKB/TrEMBL
Pfam HIG_1_N UniProtKB/TrEMBL
PhenoGen Higd2al1 PhenoGen
PROSITE HIG1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001071 RatGTEx
UniProt D3ZU87 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Higd2al1  HIG1 hypoxia inducible domain family, member 2A-like 1  LOC683356  similar to HIG1 domain family, member 2A  Data merged from RGD:1588013 1643240 APPROVED
2010-04-23 Higd2al1  HIG1 hypoxia inducible domain family, member 2A-like 1  LOC688606  similar to HIG1 domain family, member 2A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC688606  similar to HIG1 domain family, member 2A      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC683356  similar to HIG1 domain family, member 2A      Symbol and Name status set to provisional 70820 PROVISIONAL