Eif4a1-ps8 (eukaryotic translation initiation factor 4A1, pseudogene 8) - Rat Genome Database

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Gene: Eif4a1-ps8 (eukaryotic translation initiation factor 4A1, pseudogene 8) Rattus norvegicus
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Symbol: Eif4a1-ps8
Name: eukaryotic translation initiation factor 4A1, pseudogene 8
RGD ID: 1586428
Description: Predicted to enable several functions, including ATP binding activity; RNA helicase activity; and nucleic acid binding activity. Predicted to be involved in translational initiation.
Type: pseudo (Ensembl: protein-coding)
RefSeq Status: MODEL
Previously known as: LOC688672; similar to eukaryotic translation initiation factor 4A, isoform 1
Related Functional Gene: Eif4a1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8682,358,758 - 82,360,076 (+)NCBIGRCr8
mRatBN7.2676,623,866 - 76,625,179 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl676,623,866 - 76,625,392 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0680,022,604 - 80,023,901 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl680,022,613 - 80,023,829 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0689,548,476 - 89,549,779 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4679,623,313 - 79,624,532 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera675,381,537 - 75,382,835 (+)NCBICelera
Cytogenetic Map6q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

Genomics

Variants

.
Variants in Eif4a1-ps8
38 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:91
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000071997
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65672856290198260Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)67222764181132889Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 13 1 15 1 6 1 8 9
Below cutoff 2 20 28 24 4 24 7 9 49 19 26 2 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000071997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl676,623,866 - 76,625,392 (+)Ensembl
Rnor_6.0 Ensembl680,022,613 - 80,023,829 (+)Ensembl
RefSeq Acc Id: XR_146036
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0680,022,604 - 80,023,901 (+)NCBI
Rnor_5.0689,548,476 - 89,549,779 (+)NCBI
Sequence:
RefSeq Acc Id: XR_147019
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera675,381,537 - 75,382,835 (+)NCBI
Sequence:
Protein Sequences
Ensembl Protein ENSRNOP00000087325.1
Reference Protein Sequences
Protein Domains
DEAD-box RNA helicase Q   Helicase ATP-binding   Helicase C-terminal

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-37390 BioCyc
Ensembl Genes ENSRNOG00000046740 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071997.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro DEAD/DEAH_box_helicase_dom UniProtKB/TrEMBL
  EIF4A_DEADc UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RNA-helicase_DEAD-box_CS UniProtKB/TrEMBL
  RNA_helicase_DEAD_Q_motif UniProtKB/TrEMBL
NCBI Gene 688672 ENTREZGENE
PANTHER ATP-DEPENDENT RNA HELICASE DBP3 UniProtKB/TrEMBL
  SIMILAR TO EUKARYOTIC TRANSLATION INITIATION FACTOR 4A, ISOFORM 1 UniProtKB/TrEMBL
Pfam DEAD UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
PhenoGen Eif4a1-ps8 PhenoGen
PROSITE DEAD_ATP_HELICASE UniProtKB/TrEMBL
  HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
  Q_MOTIF UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046740 RatGTEx
SMART DEXDc UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6GF11_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-10 Eif4a1-ps8  eukaryotic translation initiation factor 4A1, pseudogene 8  LOC688672  similar to eukaryotic translation initiation factor 4A, isoform 1  Symbol and Name Changed 1299863 APPROVED
2008-01-09 LOC688672  similar to eukaryotic translation initiation factor 4A, isoform 1  LOC687673  similar to eukaryotic translation initiation factor 4A, isoform 1  Data merged from RGD:1583034 1643240 APPROVED
2006-11-19 LOC688672  similar to eukaryotic translation initiation factor 4A, isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687673  similar to eukaryotic translation initiation factor 4A, isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL