Pomt2 (protein-O-mannosyltransferase 2)

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Gene: Pomt2 (protein-O-mannosyltransferase 2) Rattus norvegicus

Analyze

Symbol:

Pomt2

Name:

protein-O-mannosyltransferase 2

RGD ID:

1586427

Description:

Predicted to enable mannosyltransferase activity. Involved in positive regulation of protein O-linked glycosylation. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Human ortholog(s) of this gene implicated in lissencephaly and muscular dystrophy (multiple). Orthologous to human POMT2 (protein O-mannosyltransferase 2); PARTICIPATES IN O-linked glycan biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC688673; protein O-mannosyl-transferase 2; similar to Protein O-mannosyl-transferase 2 (Dolichyl-phosphate-mannose--protein mannosyltransferase 2)

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	POMT2 (protein O-mannosyltransferase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Pomt2 (protein-O-mannosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pomt2 (protein O-mannosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	POMT2 (protein O-mannosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	POMT2 (protein O-mannosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pomt2 (protein O-mannosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	POMT2 (protein O-mannosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	POMT2 (protein O-mannosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pomt2 (protein O-mannosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	POMT2 (protein O-mannosyltransferase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pomt2 (protein-O-mannosyltransferase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pomt2 (protein-O-mannosyltransferase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PMT2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	tw	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PMT3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PMT6	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pomt2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	106,755,462 - 106,794,849 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	106,755,462 - 106,794,849 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	106,923,228 - 106,962,583 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	6	107,222,064 - 107,261,421 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	6	106,591,741 - 106,631,092 (-)	NCBI	Rnor_WKY
Rnor_6.0	6	111,137,329 - 111,176,991 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	111,135,349 - 111,176,918 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	120,423,138 - 120,461,156 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	111,242,085 - 111,259,180 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	6	104,576,761 - 104,616,136 (-)	NCBI		Celera
Cytogenetic Map	6	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

autosomal recessive limb-girdle muscular dystrophy (ISO)

autosomal recessive limb-girdle muscular dystrophy type 2N (ISO)

congenital muscular dystrophy (ISO)

congenital muscular dystrophy-dystroglycanopathy type A1 (ISO)

congenital muscular dystrophy-dystroglycanopathy type A2 (ISO)

genetic disease (ISO)

hereditary sensory and autonomic neuropathy type 1C (ISO)

intellectual disability (ISO)

isolated elevated serum creatine phosphokinase levels (ISO)

lissencephaly (ISO)

muscular dystrophy (ISO)

muscular dystrophy-dystroglycanopathy type B2 (ISO)

Walker-Warburg syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

aflatoxin B1 (ISO)

amphetamine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cisplatin (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

fipronil (EXP)

folic acid (ISO)

gentamycin (EXP)

ketamine (EXP)

perfluorooctane-1-sulfonic acid (ISO)

quercitrin (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

Soman (EXP)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

trichloroethene (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

basement membrane organization (ISO)

dentate gyrus development (ISO)

positive regulation of protein O-linked glycosylation (IDA)

protein O-linked mannosylation (ISO)

reactive gliosis (ISO)

Cellular Component

cytosol (IEA,ISO)

endoplasmic reticulum membrane (IEA)

nucleolus (IEA,ISO)

nucleoplasm (IEA,ISO)

Molecular Function

dolichyl-phosphate-mannose-protein mannosyltransferase activity (IEA)

mannosyltransferase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

O-linked glycan biosynthetic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	POMT2 gene mutation in limb-girdle muscular dystrophy with inflammatory changes.	Biancheri R, etal., Biochem Biophys Res Commun. 2007 Nov 30;363(4):1033-7. Epub 2007 Sep 25.
2.	Molecular heterogeneity in fetal forms of type II lissencephaly.	Bouchet C, etal., Hum Mutat. 2007 Oct;28(10):1020-7.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Molecular cloning and characterization of rat Pomt1 and Pomt2.	Manya H, etal., Glycobiology. 2006 Sep;16(9):863-73. Epub 2006 May 16.
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	POMT2 mutations cause alpha-dystroglycan hypoglycosylation and Walker-Warburg syndrome.	van Reeuwijk J, etal., J Med Genet. 2005 Dec;42(12):907-12. Epub 2005 May 13.
12.	New POMT2 mutations causing congenital muscular dystrophy: identification of a founder mutation.	Yanagisawa A, etal., Neurology. 2007 Sep 18;69(12):1254-60. Epub 2007 Jul 18.

Additional References at PubMed

PMID:15632090	PMID:28512129

Genomics

Comparative Map Data

Pomt2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	106,755,462 - 106,794,849 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	106,755,462 - 106,794,849 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	106,923,228 - 106,962,583 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	6	107,222,064 - 107,261,421 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	6	106,591,741 - 106,631,092 (-)	NCBI	Rnor_WKY
Rnor_6.0	6	111,137,329 - 111,176,991 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	111,135,349 - 111,176,918 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	120,423,138 - 120,461,156 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	111,242,085 - 111,259,180 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	6	104,576,761 - 104,616,136 (-)	NCBI		Celera
Cytogenetic Map	6	q31	NCBI

POMT2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	77,274,956 - 77,320,883 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	14	77,274,956 - 77,320,883 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	77,741,299 - 77,787,226 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	76,811,052 - 76,856,970 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	76,811,053 - 76,856,970	NCBI
Celera	14	57,779,861 - 57,825,801 (-)	NCBI		Celera
Cytogenetic Map	14	q24.3	NCBI
HuRef	14	57,907,710 - 57,953,334 (-)	NCBI		HuRef
CHM1_1	14	77,680,748 - 77,726,684 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	71,484,305 - 71,530,246 (-)	NCBI		T2T-CHM13v2.0

Pomt2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	87,153,635 - 87,194,742 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	87,153,635 - 87,194,742 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	87,106,861 - 87,147,968 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	87,106,861 - 87,147,968 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	88,447,816 - 88,488,852 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	87,995,969 - 88,037,005 (-)	NCBI		MGSCv36	mm8
Celera	12	88,571,489 - 88,612,407 (-)	NCBI		Celera
Cytogenetic Map	12	D2	NCBI

Pomt2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955438	1,179,064 - 1,218,860 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955438	1,179,064 - 1,218,860 (-)	NCBI	ChiLan1.0	ChiLan1.0

POMT2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	14	77,574,989 - 77,621,250 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	57,827,841 - 57,874,100 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	77,029,625 - 77,075,819 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	77,029,625 - 77,075,806 (-)	Ensembl	panpan1.1		panPan2

POMT2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	50,091,861 - 50,133,388 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	50,091,865 - 50,133,442 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	49,779,581 - 49,820,925 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	50,325,424 - 50,366,778 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	50,323,356 - 50,366,973 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	49,988,099 - 50,029,629 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	50,011,110 - 50,052,484 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	50,409,323 - 50,450,667 (-)	NCBI		UU_Cfam_GSD_1.0

Pomt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	25,927,115 - 25,966,356 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936488	6,102,524 - 6,141,875 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936488	6,102,612 - 6,141,842 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

POMT2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	100,350,460 - 100,392,332 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	100,350,451 - 100,392,164 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	106,564,993 - 106,604,420 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

POMT2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	54,519,980 - 54,567,584 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	54,519,754 - 54,567,584 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	42,720,189 - 42,767,567 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pomt2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	24,595,702 - 24,636,937 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	24,595,748 - 24,636,845 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pomt2
282 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	189
Count of miRNA genes:	129
Interacting mature miRNAs:	137
Transcripts:	ENSRNOT00000016242
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
731173	Uae22	Urinary albumin excretion QTL 22	10.1		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
2290393	Uae37	Urinary albumin excretion QTL 37		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
1641904	Alcrsp4	Alcohol response QTL 4			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	6	67262953	112262953	Rat
1300075	Glom7	Glomerulus QTL 7	5.6	0.0000002	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	6	71201409	116201409	Rat
1331789	Rf37	Renal function QTL 37	3.224		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	72202632	115200186	Rat
70196	BpQTLcluster7	Blood pressure QTL cluster 7	6.82		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	72202632	117202632	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	72202632	130729475	Rat
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	72202632	130919985	Rat
1581550	Pur8	Proteinuria QTL 8			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	72227641	130729205	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	72227641	130729205	Rat
724524	Uae2	Urinary albumin excretion QTL 2	2.7	0.0005	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	73463459	109394713	Rat
737827	Hcar11	Hepatocarcinoma resistance QTL 11	4.4		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	6	82523650	110548006	Rat
738034	Anxrr5	Anxiety related response QTL 5	5.9		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	6	84130881	129130881	Rat
10054138	Gmadr3	Adrenal mass QTL 3	3.68	0.00045	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	6	85140138	130140138	Rat
10054123	Srcrt6	Stress Responsive Cort QTL 6	2.5	0.0043	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	85140138	130140138	Rat
724513	Uae14	Urinary albumin excretion QTL 14	6.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	85311061	133478515	Rat
1300076	Glom8	Glomerulus QTL 8	7	0.000000009	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	6	86894788	131894788	Rat
2303624	Vencon5	Ventilatory control QTL 5	4.45		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	6	88047916	133047916	Rat
1331725	Bp212	Blood pressure QTL 212	3.52475		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	93701310	128713626	Rat
61414	Pia3	Pristane induced arthritis QTL 3	4.5		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	6	94968928	137848904	Rat
12801411	Schws8	Schwannoma susceptibility QTL 8			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	94968928	139968928	Rat
8552796	Vie3	Viral induced encephalitis QTL 3	2.6		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	6	96833997	140994061	Rat
1358355	Srcrt4	Stress Responsive Cort QTL 4	6.39		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	100364669	140994061	Rat
2313399	Anxrr28	Anxiety related response QTL 28			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	6	100671796	132340886	Rat
1331797	Bp213	Blood pressure QTL 213	3.291		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	104085867	128713626	Rat
71111	Iddm8	Insulin dependent diabetes mellitus QTL 8	1.9	0.002	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	6	105156861	140994061	Rat
4145118	Mcs26	Mammary carcinoma susceptibility QTL 26		0.0001	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	106752656	132339866	Rat

Markers in Region

RH140484

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	106,763,032 - 106,763,135 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	111,144,901 - 111,145,003	NCBI	Rnor6.0
Rnor_5.0	6	120,430,710 - 120,430,812	UniSTS	Rnor5.0
RGSC_v3.4	6	111,249,507 - 111,249,609	UniSTS	RGSC3.4
Celera	6	104,584,332 - 104,584,434	UniSTS
RH 3.4 Map	6	748.9	UniSTS
Cytogenetic Map	6	q31	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		22	11	4	6	4			70	33	40	10
Low	3	21	46	37	13	37	8	11	4	2	1	1	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001047114	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005505589	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005505590	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB246667	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473982	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000166	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000016242 ⟹ ENSRNOP00000016242

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	106,755,462 - 106,794,849 (-)	Ensembl
Rnor_6.0 Ensembl	6	111,135,349 - 111,176,918 (-)	Ensembl

RefSeq Acc Id:

NM_001047114 ⟹ NP_001040579

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	106,755,462 - 106,794,849 (-)	NCBI
Rnor_6.0	6	111,137,329 - 111,176,991 (-)	NCBI
Rnor_5.0	6	120,423,138 - 120,461,156 (-)	NCBI
RGSC_v3.4	6	111,242,085 - 111,259,180 (-)	RGD
Celera	6	104,576,761 - 104,616,136 (-)	RGD

Sequence:

show sequence

ACAGCTCTTCTCCGCGTTTCTCAGGAGCGACCCTCAACCCCGGATCTGCGGCACAGACCTTCCC
GGCTTGCATCTCGCCCGTCGGCCAGCCAAGAAAGTCAGTTCTCAGGACTAGAAGATGACTGAGG
CCTAGCGGGGTCCAGAGAGCGAAGGTTGGACTAGATGGCGTTCCCTCCTTCGGGCTGGCCCCGC
CCCCGCCTCCTGAGCTCTGGGAGTTGTAGTTCATGAGCGGCCCCGAGTCTGTCTGTCCTTCGCG
TCCCTCCGCCTCCTGCTATGTTTTACGCCTCAGGCCGCCTCTTAGCCGCCCGGGAGGCCACCAC
ACTCTACGCCCCTCCCAGAGCCCGGGGCCCGGCACTCCGCGGCAAACGGAGGGAACTACAAATC
CCATGGCACCTCGAGACGCCCTCTTACGACTCCTTGACGGGGCAGCGGACAAGACCCGGCGTGC
CTCCGGCCCGGAGGGTGATCCTTAGAAAGGGGAGGATGCCGCCGGCCATAGGCGGTGGCCTAGC
GGGCTCGGAGCTGCGTCCCCGTAGGGGCCGCAGTGTGCAGCAGGCTGCCAGAGCCGTGAGCCGA
GACGTGGTCCCCGAGGCTGCAACGCGGAAACTTAAACGGCCTGCTTGGAGCTCGCGGCGCTTCC
AGGCGGCAGGCTGGTGGGCCACGCTGGCTGTGGTGACGCTGCTGTCCTTTGCCACCCGCTTTCA
CAGGCTGGACCAGCCGGCACACATCTGTTGGGATGAGACTCACTTTGGAAAAATGGGAAGTTAC
TACATTAACCGCACCTTTTTCTTCGATGTGCACCCACCACTGGGAAAGATGCTGATTGGCCTTG
CTGGCTACCTGAGTGGATATGATGGTACCTTTTTGTTCCAGAAGCCTGGGGACCGATACGAGCA
CCACAGCTACATGGGGATGAGAGGGTTCTGTGCTTTCCTGGGTTCCTGGCTGATCCCCTTTGCC
TACCTCACTGTACTGGATCTGTCCAAGTCCTTCCCAGCAGCACTGCTCACCGCTGCCCTGCTCA
CCTGTGACACGGGATGCCTCACTCTGTCCCAGTACATCCTCCTTGACCCCATCCTGATGTTCTT
CATCATGGCTGCCATGCTGAGCATGGTCAAGTACAACTCCTTCGCTAACAGGCCTTTCTCTGCC
CCCTGGTGGTTCTGGCTCAGCCTGACTGGCATTAGTCTTGCTGGCGCTTTAGGGGTCAAATTTG
TTGGCCTCTTTATCATTGTGCAAGTGGGGTTGAACACCATCTCAGACCTCTGGCACCTGTTTGG
AGACCTCAGTCTTTCACTGGTGACTGTGGGGAAACACCTGACTGCTCGCATCCTGTGCCTCATA
GTGCTGCCCTTGGTGCTCTATGTGACCATTTTTGCTGTTCATGTCATGGTGCTGAATAAAAGTG
GTCCTGGTGATGGCTTCTTCAGTTCTGCCTTTCAAGCCCGACTTTCAGGGAACAGCCTTCACAA
TGCTTCTATCCCTGAACACTTGGCGTATGGCTCTGTAATCACTGTGAAGAACCTCCGGATGGCC
ATCGGCTACCTTCACTCCCACAGGCACCTCTACCCTGAGGGCATTGGTGCACGCCAGCAGCAGG
TTACCACCTATTTGCATAAGGACTACAACAACCTGTGGATTATCAAGAAATACAATACCAACAC
AGATCCTCTAGACCCTTCCTTCCCAGTGGAGTTTGTCAGACATGGGGACATCATACGACTAGAA
CACAAAGAAACTACTCGGAACCTGCACAGTCACTATCATGAGGCTCCCCTGACCCGGAAGCACT
ATCAGGTCACTGGCTATGGCATAAATGGGACAGGGGACTCAAATGACTTCTGGAGGATTGAAGT
TGTAAATAGAAAATTTGGGAACCGGATCAAGGTACTGAGAAGTCGAATTCGCTTCATCCATTTG
GTTACAGGTTGTGTCCTGGGATCTTCAGGAAAGATTCTGCCTAAGTGGGGCTGGGAGCAGTTGG
AAGTTACTTGTAATCCGTACTTAAAAGAAACCAGTAACTCCATTTGGAACATAGAAGAACATAT
CAATCCCAAACTGCCAAACATCAGCCTGGATGTGCTGCAACCCAGTTTTCCTGAGATCTTGCTG
GAGTCCCACATGGTCATGATCCGGGGAAACAATGGCCTCAAACCTAAGGACAATGAGTTTACAT
CCAAACCCTGGCACTGGCCTATCAATTATCAGGGCCTGCGCTTCTCAGGGGCCAATGACACGGA
CTTCCGAGTCTATCTGCTCGGCAACCCTGTGGTCTGGTGGCTCAACCTGGTGAGCCTCGTCCTC
TACCTCCTCACGGGCAGCACCATTGCCATCGCCATGCAGAGAGGGATACAGCTGCCTGCAGAGT
TGCAAGGGCTGACCAAGCTGCTGCTGCGAGGAGGTGGCCAGCTGCTCCTGGGATGGACGCTCCA
TTACTTCCCTTTCTTCCTGATGGGCCGCGTCCTCTACTTCCACCACTACTTCCCAGCCATGCTC
TTTTCCAGCATGTTGACAGGTCTCCTGTGGGATACTCTTCTGCGGTTCTGTGCCTGGGCCTTGG
CCCCTTCTCCCCTGGGTAGGAGAATACATATGGTGGGAATCCTGAGCCTGCTTCTGGCAACTGC
CTACAGCTTCTACCTCTTTCACCCTCTGGCTTATGGGATGGTTGGTCCCCTAGCCCAGGAACCT
GAGAGTCCAATGGCAGGACTGAGGTGGCTGGAATCATGGGACTTTTGAGGCCACTGCCAGGACC
CCAGCCTGGATCCAGGTATTGTCCAGGGACACCCAGCTATGAAGCCTGACCCTGGGCCCTTCCA
GCTTCAAGGGCGCTGCCTGAGAAGCCCAAAGCATTCTGCTGCCCCCCAGGACCAAACTCTGGGA
AATGACATGGATTTCACTAAACACTAAAAAGAGCCACAGCCCTGTCTATAGCACCTACATGGGG
CTCTTGACCTACAGCACTGCTTGGTGCCAGTTCCTGTGAAACACAAGGAAAGCCGGTGTGAGTG
TCAGGGTACATATGCCCATCCCTTTGGAGTGTGTAGACCATGTAACTGTGGTAGCCAAGTGTCA
TAAATTCCAGAAATGGGTACAGGCT

hide sequence

RefSeq Acc Id:

XM_039112959 ⟹ XP_038968887

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	106,762,907 - 106,794,614 (-)	NCBI

RefSeq Acc Id:

XM_039112960 ⟹ XP_038968888

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	106,763,899 - 106,794,614 (-)	NCBI

RefSeq Acc Id:

XR_005505589

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	106,755,850 - 106,794,614 (-)	NCBI

RefSeq Acc Id:

XR_005505590

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	106,755,850 - 106,794,614 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001040579	(Get FASTA)	NCBI Sequence Viewer
	XP_038968887	(Get FASTA)	NCBI Sequence Viewer
	XP_038968888	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAE97674	(Get FASTA)	NCBI Sequence Viewer
	EDL81625	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001040579 ⟸ NM_001047114

- UniProtKB:

Q14U74 (UniProtKB/TrEMBL), F1LRW3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFYASGRLLAAREATTLYAPPRARGPALRGKRRELQIPWHLETPSYDSLTGQRTRPGVPPARRV
ILRKGRMPPAIGGGLAGSELRPRRGRSVQQAARAVSRDVVPEAATRKLKRPAWSSRRFQAAGWW
ATLAVVTLLSFATRFHRLDQPAHICWDETHFGKMGSYYINRTFFFDVHPPLGKMLIGLAGYLSG
YDGTFLFQKPGDRYEHHSYMGMRGFCAFLGSWLIPFAYLTVLDLSKSFPAALLTAALLTCDTGC
LTLSQYILLDPILMFFIMAAMLSMVKYNSFANRPFSAPWWFWLSLTGISLAGALGVKFVGLFII
VQVGLNTISDLWHLFGDLSLSLVTVGKHLTARILCLIVLPLVLYVTIFAVHVMVLNKSGPGDGF
FSSAFQARLSGNSLHNASIPEHLAYGSVITVKNLRMAIGYLHSHRHLYPEGIGARQQQVTTYLH
KDYNNLWIIKKYNTNTDPLDPSFPVEFVRHGDIIRLEHKETTRNLHSHYHEAPLTRKHYQVTGY
GINGTGDSNDFWRIEVVNRKFGNRIKVLRSRIRFIHLVTGCVLGSSGKILPKWGWEQLEVTCNP
YLKETSNSIWNIEEHINPKLPNISLDVLQPSFPEILLESHMVMIRGNNGLKPKDNEFTSKPWHW
PINYQGLRFSGANDTDFRVYLLGNPVVWWLNLVSLVLYLLTGSTIAIAMQRGIQLPAELQGLTK
LLLRGGGQLLLGWTLHYFPFFLMGRVLYFHHYFPAMLFSSMLTGLLWDTLLRFCAWALAPSPLG
RRIHMVGILSLLLATAYSFYLFHPLAYGMVGPLAQEPESPMAGLRWLESWDF

hide sequence

RefSeq Acc Id:

ENSRNOP00000016242 ⟸ ENSRNOT00000016242

RefSeq Acc Id:	XP_038968887 ⟸ XM_039112959
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038968888 ⟸ XM_039112960
- Peptide Label:	isoform X2

Protein Domains

MIR

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q14U74-F1-model_v2	AlphaFold	Q14U74	1-820	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694752

Promoter ID:

EPDNEW_R5277

Type:

single initiation site

Name:

Pomt2_1

Description:

protein-O-mannosyltransferase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	111,176,992 - 111,177,052	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1586427	AgrOrtholog
BioCyc Gene	G2FUF-36727	BioCyc
BioCyc Pathway	PWY-7922 [protein O-mannosylation II (mammals, core M1 and core M2)]	BioCyc
	PWY-7979 [protein O-mannosylation III (mammals, core M3)]	BioCyc
Ensembl Genes	ENSRNOG00000012146	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000016242	ENTREZGENE
	ENSRNOP00000016242.5	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000016242	ENTREZGENE
	ENSRNOT00000016242.8	UniProtKB/TrEMBL
Gene3D-CATH	2.80.10.50	UniProtKB/TrEMBL
InterPro	GlyclTrfase_39	UniProtKB/TrEMBL
	Glyco_trans_39	UniProtKB/TrEMBL
	MIR_dom_sf	UniProtKB/TrEMBL
	MIR_motif	UniProtKB/TrEMBL
	PMT_4TMC	UniProtKB/TrEMBL
KEGG Report	rno:688673	UniProtKB/TrEMBL
NCBI Gene	688673	ENTREZGENE
PANTHER	PROTEIN O-MANNOSYL-TRANSFERASE 2	UniProtKB/TrEMBL
	PTHR10050	UniProtKB/TrEMBL
Pfam	MIR	UniProtKB/TrEMBL
	PMT	UniProtKB/TrEMBL
	PMT_4TMC	UniProtKB/TrEMBL
PhenoGen	Pomt2	PhenoGen
PROSITE	MIR	UniProtKB/TrEMBL
SMART	MIR	UniProtKB/TrEMBL
Superfamily-SCOP	MIR	UniProtKB/TrEMBL
UniProt	F1LRW3	ENTREZGENE
	Q14U74	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F1LRW3	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-14	Pomt2	protein-O-mannosyltransferase 2	LOC688673	similar to Protein O-mannosyl-transferase 2 (Dolichyl-phosphate-mannose--protein mannosyltransferase 2)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	LOC688673	similar to Protein O-mannosyl-transferase 2 (Dolichyl-phosphate-mannose--protein mannosyltransferase 2)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)