Klrb1a (killer cell lectin-like receptor subfamily B, member 1A) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Klrb1a (killer cell lectin-like receptor subfamily B, member 1A) Rattus norvegicus
Analyze
Symbol: Klrb1a
Name: killer cell lectin-like receptor subfamily B, member 1A
RGD ID: 1586149
Description: Predicted to enable signaling receptor activity. Predicted to be involved in regulation of natural killer cell mediated cytotoxicity. Predicted to be integral component of membrane. Predicted to be active in cell surface and plasma membrane. Orthologous to human KLRB1 (killer cell lectin like receptor B1); PARTICIPATES IN malaria pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: antigen 3.2.3; CD161 antigen-like family member A; killer cell lectin-like receptor subfamily B member 1A; killer cell lectin-like receptor subfamily B, member 1A (mapped); Klrb1a_mapped; natural killer cell surface protein P1-3.2.3; NKR-P1 3.2.3; NKR-P1A; Nkrp1a
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: Klrb1aem1Mcwi   Klrb1aem2Mcwi  
Genetic Models: SHR-Klrb1aem2Mcwi SHR-Klrb1aem1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24161,890,577 - 161,904,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4161,890,577 - 161,961,675 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4168,125,617 - 168,139,099 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04163,908,558 - 163,922,040 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04162,542,599 - 162,556,083 (-)NCBIRnor_WKY
Rnor_6.04161,950,270 - 161,966,582 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4161,949,817 - 162,025,187 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04227,150,602 - 227,167,004 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44165,637,478 - 165,654,188 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4150,591,734 - 150,605,311 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)
melanoma  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell surface  (IBA)
membrane  (IEA)
plasma membrane  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genomic structure and strain-specific expression of the natural killer cell receptor NKR-P1. Giorda R, etal., J Immunol 1992 Sep 15;149(6):1957-63.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2399464   PMID:9022000   PMID:12618485   PMID:17462921   PMID:19130483   PMID:19535641   PMID:30587601  


Genomics

Comparative Map Data
Klrb1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24161,890,577 - 161,904,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4161,890,577 - 161,961,675 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4168,125,617 - 168,139,099 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04163,908,558 - 163,922,040 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04162,542,599 - 162,556,083 (-)NCBIRnor_WKY
Rnor_6.04161,950,270 - 161,966,582 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4161,949,817 - 162,025,187 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04227,150,602 - 227,167,004 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44165,637,478 - 165,654,188 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4150,591,734 - 150,605,311 (-)NCBICelera
Cytogenetic Map4q42NCBI
KLRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38129,594,551 - 9,607,916 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl129,594,551 - 9,607,916 (-)EnsemblGRCh38hg38GRCh38
GRCh37129,747,147 - 9,760,512 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36129,639,137 - 9,651,764 (-)NCBINCBI36Build 36hg18NCBI36
Build 34129,639,137 - 9,651,764NCBI
Celera1214,909,231 - 14,921,909 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef129,490,635 - 9,503,276 (-)NCBIHuRef
CHM1_1129,716,848 - 9,729,496 (-)NCBICHM1_1
T2T-CHM13v2.0129,480,754 - 9,494,170 (-)NCBIT2T-CHM13v2.0
Klrb1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396128,586,190 - 128,599,897 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6128,586,190 - 128,600,496 (-)EnsemblGRCm39 Ensembl
GRCm386128,609,227 - 128,622,934 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6128,609,227 - 128,623,533 (-)EnsemblGRCm38mm10GRCm38
MGSCv376128,559,245 - 128,572,952 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366128,574,846 - 128,588,444 (-)NCBIMGSCv36mm8
Celera6130,286,421 - 130,300,140 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map663.06NCBI
KLRB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1129,892,986 - 9,905,255 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl129,892,986 - 9,905,255 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0129,644,078 - 9,656,303 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
KLRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12736,355,917 - 36,376,172 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2736,355,986 - 36,376,501 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2710,241,214 - 10,263,747 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02736,707,314 - 36,729,874 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2736,707,374 - 36,729,870 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12736,606,421 - 36,612,015 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02736,617,769 - 36,640,369 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0279,773,520 - 9,788,771 (-)NCBIUU_Cfam_GSD_1.0
LOC101962075
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494598,065,021 - 98,076,420 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936870702,606 - 706,341 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLRB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl562,244,713 - 62,257,694 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1562,244,787 - 62,257,691 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2565,081,320 - 65,094,181 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLRB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1119,471,914 - 9,516,338 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl119,481,275 - 9,494,310 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660891,550,332 - 1,563,208 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Position Markers
RH128601  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24161,890,619 - 161,890,806 (+)MAPPERmRatBN7.2
mRatBN7.24161,948,776 - 161,948,966 (+)MAPPERmRatBN7.2
Rnor_6.04162,012,369 - 162,012,558NCBIRnor6.0
Rnor_6.04161,950,313 - 161,950,499NCBIRnor6.0
Rnor_5.04227,212,474 - 227,212,663UniSTSRnor5.0
Rnor_5.04227,151,567 - 227,151,753UniSTSRnor5.0
RGSC_v3.44165,637,521 - 165,637,707UniSTSRGSC3.4
RGSC_v3.44165,699,206 - 165,699,395UniSTSRGSC3.4
Celera4150,650,000 - 150,650,189UniSTS
Celera4150,591,777 - 150,591,963UniSTS
Cytogenetic Map4q42UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat


Genetic Models
This gene Klrb1a is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:220
Count of miRNA genes:155
Interacting mature miRNAs:174
Transcripts:ENSRNOT00000009594
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009594   ⟹   ENSRNOP00000009594
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4161,890,577 - 161,904,094 (-)Ensembl
Rnor_6.0 Ensembl4161,949,817 - 161,966,616 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000009904   ⟹   ENSRNOP00000009904
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4162,009,407 - 162,025,187 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085887   ⟹   ENSRNOP00000075481
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4161,890,600 - 161,961,653 (-)Ensembl
Rnor_6.0 Ensembl4161,950,596 - 162,025,090 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104988   ⟹   ENSRNOP00000090889
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4161,890,577 - 161,961,675 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111200   ⟹   ENSRNOP00000095158
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4161,890,600 - 161,961,675 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113391   ⟹   ENSRNOP00000085432
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4161,890,577 - 161,904,094 (-)Ensembl
RefSeq Acc Id: NM_001010964   ⟹   NP_001010964
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24161,890,577 - 161,904,050 (-)NCBI
Rnor_6.04161,950,270 - 161,966,582 (-)NCBI
Rnor_5.04227,150,602 - 227,167,004 (-)NCBI
RGSC_v3.44165,637,478 - 165,654,188 (-)RGD
Celera4150,591,734 - 150,605,311 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001010964   ⟸   NM_001010964
- UniProtKB: A4KWA2 (UniProtKB/Swiss-Prot),   P27471 (UniProtKB/Swiss-Prot),   B7TYL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009594   ⟸   ENSRNOT00000009594
RefSeq Acc Id: ENSRNOP00000075481   ⟸   ENSRNOT00000085887
RefSeq Acc Id: ENSRNOP00000009904   ⟸   ENSRNOT00000009904
RefSeq Acc Id: ENSRNOP00000085432   ⟸   ENSRNOT00000113391
RefSeq Acc Id: ENSRNOP00000090889   ⟸   ENSRNOT00000104988
RefSeq Acc Id: ENSRNOP00000095158   ⟸   ENSRNOT00000111200
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27471-F1-model_v2 AlphaFold P27471 1-223 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
4 161953856 161953857 C T snv FHL/EurMcwi (MCW), PVG/Seac (2019), FHH/EurMcwi (MCW), WAG/RijCrl (2020), FHH/EurMcwi (2019)
4 161954305 161954306 T C snv WKY/N (2020), WKY/NCrl (2019)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
4 227155240 227155241 C T snv IS/Kyo (KyushuU), FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), SDLEF7/Barth (UDEL), Crl:SD (UDEL), LEC/Tj (KyushuU), BUF/MNa (KyushuU), NIG-III/Hok (KyushuU), RCS/Kyo (KyushuU), IS-Tlk/Kyo (KyushuU)
4 227155689 227155690 T C snv NIG-III/Hok (KyushuU)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
4 165641505 165641506 C T snv FHH/EurMcwi (MCW), FHH/EurMcwi (MDC), FHL/EurMcwi (MCW)


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
4 161894159 161894160 C T snv FHH/EurMcwi (2019), PVG/Seac (2019), WAG/RijCrl (2020)
4 161894608 161894609 T C snv WKY/NCrl (2019), WKY/N (2020)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586149 AgrOrtholog
BioCyc Gene G2FUF-42846 BioCyc
Ensembl Genes ENSRNOG00000007310 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000009594 ENTREZGENE
  ENSRNOP00000009594.3 UniProtKB/TrEMBL
  ENSRNOP00000075481.2 UniProtKB/TrEMBL
  ENSRNOP00000085432.1 UniProtKB/TrEMBL
  ENSRNOP00000090889.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009594 ENTREZGENE
  ENSRNOT00000009594.4 UniProtKB/TrEMBL
  ENSRNOT00000085887.2 UniProtKB/TrEMBL
  ENSRNOT00000104988.1 UniProtKB/TrEMBL
  ENSRNOT00000113391.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NKR-like_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:362443 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 362443 ENTREZGENE
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klrb1a PhenoGen
PROSITE C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2KAQ0_RAT UniProtKB/TrEMBL
  A0A0H2UHF0_RAT UniProtKB/TrEMBL
  A0A8I6A029_RAT UniProtKB/TrEMBL
  A0A8I6AB27_RAT UniProtKB/TrEMBL
  A4KWA2 ENTREZGENE
  B7TYL0 ENTREZGENE, UniProtKB/TrEMBL
  KLRBA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A4KW96 UniProtKB/Swiss-Prot
  A4KWA2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-04-13   killer cell lectin-like receptor subfamily B, member 1A  Klrb1a  killer cell lectin-like receptor subfamily B, member 1A (mapped)  Name updated 737654 APPROVED
2007-04-11 Klrb1a  killer cell lectin-like receptor subfamily B, member 1A (mapped)  Klrb1a_mapped  killer cell lectin-like receptor subfamily B, member 1A (mapped)  Data Merged 737654 APPROVED
2006-11-19 Klrb1a  killer cell lectin-like receptor subfamily B, member 1A (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Klrb1a_mapped  killer cell lectin-like receptor subfamily B, member 1A (mapped)      Symbol and Name updated 1556543 APPROVED
2002-06-10 Klrb1a  Killer cell lectin-like receptor subfamily B, member 1a      Symbol and Name status set to approved 70586 APPROVED