Mtrf1 (mitochondrial translation release factor 1) - Rat Genome Database

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Gene: Mtrf1 (mitochondrial translation release factor 1) Rattus norvegicus
Analyze
Symbol: Mtrf1
Name: mitochondrial translation release factor 1
RGD ID: 1584329
Description: Predicted to enable translation release factor activity. Predicted to be involved in mitochondrial translational termination. Predicted to be active in mitochondrion. Orthologous to human MTRF1 (mitochondrial translation release factor 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC686234; mitochondrial translational release factor 1; peptide chain release factor 1, mitochondrial; similar to Peptide chain release factor 1, mitochondrial precursor (MRF-1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21554,776,885 - 54,804,699 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1554,776,937 - 54,804,704 (+)Ensembl
Rnor_6.01561,662,000 - 61,689,867 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1561,662,264 - 61,689,862 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01565,326,329 - 65,354,179 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1554,360,012 - 54,387,999 (+)NCBICelera
Cytogenetic Map15q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:14651853   PMID:18614015  


Genomics

Comparative Map Data
Mtrf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21554,776,885 - 54,804,699 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1554,776,937 - 54,804,704 (+)Ensembl
Rnor_6.01561,662,000 - 61,689,867 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1561,662,264 - 61,689,862 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01565,326,329 - 65,354,179 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1554,360,012 - 54,387,999 (+)NCBICelera
Cytogenetic Map15q12NCBI
MTRF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381341,216,369 - 41,312,038 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1341,216,369 - 41,263,577 (-)EnsemblGRCh38hg38GRCh38
GRCh371341,790,505 - 41,886,174 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361340,688,516 - 40,735,713 (-)NCBINCBI36hg18NCBI36
Build 341340,688,515 - 40,735,713NCBI
Celera1322,847,948 - 22,895,130 (-)NCBI
Cytogenetic Map13q14.11NCBI
HuRef1322,590,363 - 22,637,432 (-)NCBIHuRef
CHM1_11341,758,296 - 41,805,513 (-)NCBICHM1_1
T2T-CHM13v2.01340,435,512 - 40,531,181 (-)NCBI
Mtrf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391479,635,205 - 79,672,626 (+)NCBIGRCm39mm39
GRCm39 Ensembl1479,635,212 - 79,661,027 (+)Ensembl
GRCm381479,397,765 - 79,423,650 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1479,397,772 - 79,423,587 (+)EnsemblGRCm38mm10GRCm38
MGSCv371479,797,579 - 79,823,457 (+)NCBIGRCm37mm9NCBIm37
MGSCv361478,131,927 - 78,157,742 (+)NCBImm8
Celera1476,897,806 - 76,923,692 (+)NCBICelera
Cytogenetic Map14D3NCBI
Mtrf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555184,937,921 - 4,971,352 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555184,937,921 - 4,971,365 (+)NCBIChiLan1.0ChiLan1.0
MTRF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11341,013,655 - 41,063,765 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1341,013,549 - 41,063,765 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01322,424,083 - 22,473,485 (-)NCBIMhudiblu_PPA_v0panPan3
MTRF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1229,327,231 - 9,382,922 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl229,329,406 - 9,376,686 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha229,323,626 - 9,379,088 (+)NCBI
ROS_Cfam_1.0229,553,360 - 9,608,851 (+)NCBI
ROS_Cfam_1.0 Ensembl229,553,234 - 9,625,844 (+)Ensembl
UMICH_Zoey_3.1229,248,841 - 9,304,442 (+)NCBI
UNSW_CanFamBas_1.0229,298,372 - 9,353,887 (+)NCBI
UU_Cfam_GSD_1.0229,312,922 - 9,368,378 (+)NCBI
Mtrf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945151,511,450 - 151,552,092 (-)NCBI
SpeTri2.0NW_004936667347,617 - 388,221 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTRF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1125,603,826 - 25,638,603 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11125,603,784 - 25,638,576 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21126,579,771 - 26,610,471 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTRF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1319,475,036 - 19,547,363 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl319,474,000 - 19,519,267 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605724,676,723 - 24,764,777 (+)NCBIVero_WHO_p1.0
Mtrf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474813,849,188 - 13,897,601 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462474813,849,117 - 13,898,156 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH144368  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21554,804,408 - 54,804,564 (+)MAPPERmRatBN7.2
Rnor_6.01561,689,572 - 61,689,727NCBIRnor6.0
Rnor_5.01565,353,884 - 65,354,039UniSTSRnor5.0
Celera1554,387,704 - 54,387,859UniSTS
RH 3.4 Map15458.6UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
724545Niddm54Non-insulin dependent diabetes mellitus QTL 540.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)155079449473699215Rat
2317050Aia24Adjuvant induced arthritis QTL 242.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)155284790873690657Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:79
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000072969
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 20 12 12 8 10 72 35 36 8 8
Low 3 37 29 19 29 1 2 5 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001399523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001073018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003751518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006222040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006222041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006222042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000072969   ⟹   ENSRNOP00000067626
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1554,776,937 - 54,804,704 (+)Ensembl
Rnor_6.0 Ensembl1561,662,264 - 61,689,862 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093163   ⟹   ENSRNOP00000076141
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1554,777,099 - 54,804,562 (+)Ensembl
Rnor_6.0 Ensembl1561,674,938 - 61,689,703 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093661   ⟹   ENSRNOP00000076286
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1554,776,937 - 54,793,910 (+)Ensembl
Rnor_6.0 Ensembl1561,673,560 - 61,679,143 (+)Ensembl
RefSeq Acc Id: XM_003751518   ⟹   XP_003751566
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21554,776,887 - 54,804,699 (+)NCBI
Rnor_6.01561,662,001 - 61,689,867 (+)NCBI
Rnor_5.01565,326,329 - 65,354,179 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006252367   ⟹   XP_006252429
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21554,776,887 - 54,804,699 (+)NCBI
Rnor_6.01561,662,001 - 61,689,867 (+)NCBI
Rnor_5.01565,326,329 - 65,354,179 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006252368   ⟹   XP_006252430
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21554,776,886 - 54,804,699 (+)NCBI
Rnor_6.01561,662,001 - 61,689,867 (+)NCBI
Rnor_5.01565,326,329 - 65,354,179 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006252369   ⟹   XP_006252431
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21554,776,885 - 54,804,550 (+)NCBI
Rnor_6.01561,662,000 - 61,689,867 (+)NCBI
Rnor_5.01565,326,329 - 65,354,179 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008770927   ⟹   XP_008769149
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21554,778,273 - 54,804,699 (+)NCBI
Rnor_6.01561,663,410 - 61,689,867 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094048   ⟹   XP_038949976
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21554,776,886 - 54,804,699 (+)NCBI
RefSeq Acc Id: XM_039094049   ⟹   XP_038949977
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21554,776,886 - 54,794,029 (+)NCBI
RefSeq Acc Id: XM_039094050   ⟹   XP_038949978
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21554,776,888 - 54,804,699 (+)NCBI
RefSeq Acc Id: XM_039094051   ⟹   XP_038949979
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21554,776,888 - 54,804,699 (+)NCBI
RefSeq Acc Id: XM_039094052   ⟹   XP_038949980
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21554,778,296 - 54,804,699 (+)NCBI
RefSeq Acc Id: XM_039094053   ⟹   XP_038949981
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21554,776,888 - 54,804,699 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_003751566   ⟸   XM_003751518
- Peptide Label: isoform X1
- UniProtKB: M0RDC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252429   ⟸   XM_006252367
- Peptide Label: isoform X1
- UniProtKB: M0RDC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252431   ⟸   XM_006252369
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006252430   ⟸   XM_006252368
- Peptide Label: isoform X1
- UniProtKB: M0RDC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769149   ⟸   XM_008770927
- Peptide Label: isoform X1
- UniProtKB: M0RDC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067626   ⟸   ENSRNOT00000072969
RefSeq Acc Id: ENSRNOP00000076286   ⟸   ENSRNOT00000093661
RefSeq Acc Id: ENSRNOP00000076141   ⟸   ENSRNOT00000093163
RefSeq Acc Id: XP_038949976   ⟸   XM_039094048
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038949977   ⟸   XM_039094049
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038949979   ⟸   XM_039094051
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038949978   ⟸   XM_039094050
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038949981   ⟸   XM_039094053
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038949980   ⟸   XM_039094052
- Peptide Label: isoform X4
Protein Domains
RF_PROK_I

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RDC8-F1-model_v2 AlphaFold M0RDC8 1-446 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699853
Promoter ID:EPDNEW_R10369
Type:multiple initiation site
Name:Mtrf1_1
Description:mitochondrial translation release factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01561,662,234 - 61,662,294EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
15 61665939 61665940 T C snv LEXF4/Stm (2020), MR/N (2020), M520/NRrrcMcwi (2019), LEXF10A/StmMcwi (2020), LN/MavRrrcAek (2020), LH/MavRrrcAek (2020), LE/Stm (2019), LEXF3/Stm (2020), LEXF2B/Stm (2019), FHH/EurMcwi (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), FHH/EurMcwi (RGD), LEW/Crl (RGD), LEW/NCrlBR (RGD), MNS/Gib (RGD), SR/JrHsd (RGD), SS/Jr (RGD), SS/JrHsdMcwi (RGD), WKY/Gcrc (RGD), BUF/N (2020), FHH/EurMcwi (2019), HXB20/IpcvMcwi (2020), LEW/Crl (2019), SHR/OlalpcvMcwi (2019), M520/N (2020), MWF/Hsd (2019), SR/JrHsd (2020), SS/JrHsdMcwi (2019), WN/N (2020), WAG/RijCrl (2020), FHL/EurMcwi (MCW), GH/OmrMcwi (MCW), FHL/EurMcwi (RGD), LE/Stm (RGD), LH/MavRrrc (RGD), LN/MavRrrc (RGD), SHR/NHsd (RGD), WAG/Rij (RGD), DA/OlaHsd (2019), HXB4/IpcvMcwi (2020)
15 61666260 61666261 T G snv SR/JrHsd (MCW)
15 61675032 61675033 G A snv GK/FarMcwi (2019), WKY/N (2020), WKY/NCrl (2019), WKY/NHsd (RGD), WKY/NCrl (RGD), SHRSP/Gcrc (RGD), GK/Ox (RGD), SHRSP/A3NCrl (2019)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
15 65330251 65330252 T C snv FHH/EurMcwi (KNAW), LEC/Tj (KyushuU), HWY/Slc (KyushuU), IS-Tlk/Kyo (KyushuU), LE/Stm (KyushuU), FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), GH/OmrMcwi (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), WN/N (KNAW), LH/MavRrrc (KNAW), LN/MavRrrc (KNAW), MR/N (KNAW), SR/JrHsd (KNAW), SS/Jr (KNAW), SS/JrHsdMcwi (KNAW), WAG/Rij (KNAW), BBDP/WorN (KNAW), BUF/N (KNAW), DA/BklArbNsi (KNAW), DOB/Oda (KyushuU), FHL/EurMcwi (KNAW), LE/Stm (Illumina) (KNAW), LE/Stm (SOLiD) (KNAW), LEW/Crl (KNAW), LEW/NCrl (KNAW), M520/N (KNAW), MNS/Gib (KNAW), SHR/NCrlPrin (KNAW), SHR/NHsd (KNAW), SHR/OlaIpcv (KNAW), SHR/OlaIpcvPrin (KNAW), WKY/Gcrc (KNAW), SDLEF7/Barth (UDEL), Crl:SD (UDEL), IS/Kyo (KyushuU), NIG-III/Hok (KyushuU)
15 65339344 65339345 G A snv WKY/NHsd (KNAW), WKY/NCrl (KNAW), WKY/N (KNAW), SHRSP/Gcrc (KNAW), GK/Ox (KNAW)


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
15 54780825 54780826 T C snv BUF/N (2020), DA/OlaHsd (2019), WN/N (2020), WAG/RijCrl (2020), SS/JrHsdMcwi (2019), FHH/EurMcwi (2019), HXB20/IpcvMcwi (2020), HXB4/IpcvMcwi (2020), LEW/Crl (2019), LEXF2B/Stm (2019), LEXF3/Stm (2020), LEXF4/Stm (2020), LE/Stm (2019), LH/MavRrrcAek (2020), LN/MavRrrcAek (2020), LEXF10A/StmMcwi (2020), M520/NRrrcMcwi (2019), M520/N (2020), MR/N (2020), MWF/Hsd (2019), SHR/OlalpcvMcwi (2019), SR/JrHsd (2020)
15 54789918 54789919 G A snv GK/FarMcwi (2019), WKY/NCrl (2019), SHRSP/A3NCrl (2019), WKY/N (2020)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584329 AgrOrtholog
BioCyc Gene G2FUF-12996 BioCyc
Ensembl Genes ENSRNOG00000047106 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000067626 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000076141 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000076286 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072969 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000093163 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000093661 UniProtKB/TrEMBL
InterPro PCRF UniProtKB/TrEMBL
  Pep_chain_release_fac_I_II UniProtKB/TrEMBL
  Pep_chain_release_fac_I_sf UniProtKB/TrEMBL
KEGG Report rno:686234 UniProtKB/TrEMBL
NCBI Gene 686234 ENTREZGENE
Pfam PCRF UniProtKB/TrEMBL
  RF-1 UniProtKB/TrEMBL
PhenoGen Mtrf1 PhenoGen
PROSITE RF_PROK_I UniProtKB/TrEMBL
SMART PCRF UniProtKB/TrEMBL
Superfamily-SCOP SSF75620 UniProtKB/TrEMBL
UniProt A0A1W2Q661_RAT UniProtKB/TrEMBL
  A0A1W2Q6I8_RAT UniProtKB/TrEMBL
  M0RDC8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-12 Mtrf1  mitochondrial translation release factor 1  Mtrf1  mitochondrial translational release factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-16 Mtrf1  mitochondrial translational release factor 1  LOC686234  similar to Peptide chain release factor 1, mitochondrial precursor (MRF-1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC686234  similar to Peptide chain release factor 1, mitochondrial precursor (MRF-1)      Symbol and Name status set to provisional 70820 PROVISIONAL