Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | ISO | Dda1 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of DDA1 mRNA] | CTD | PMID:22206623 | 1,2-dimethylhydrazine | increases expression | ISO | Dda1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of DDA1 mRNA | CTD | PMID:22206623 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Dda1 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Dda1 (Mus musculus) | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of DDA1 mRNA | CTD | PMID:25975270 | 2-hydroxypropanoic acid | decreases expression | ISO | DDA1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of DDA1 mRNA | CTD | PMID:30851411 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | DDA1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of DDA1 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | DDA1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of DDA1 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of DDA1 mRNA | CTD | PMID:36041667 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of DDA1 mRNA | CTD | PMID:30047161 | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of DDA1 mRNA | CTD | PMID:30047161 | aristolochic acid A | increases expression | ISO | DDA1 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of DDA1 mRNA | CTD | PMID:33212167 | atrazine | decreases expression | ISO | DDA1 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of DDA1 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | increases expression | ISO | DDA1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of DDA1 mRNA | CTD | PMID:21632981 | benzo[a]pyrene | increases methylation | ISO | Dda1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased methylation of DDA1 intron | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | Dda1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of DDA1 mRNA | CTD | PMID:19770486 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of DDA1 mRNA | CTD | PMID:26982218 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of DDA1 mRNA | CTD | PMID:36041667 | bisphenol A | decreases methylation | ISO | DDA1 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of DDA1 gene | CTD | PMID:31601247 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of DDA1 mRNA | CTD | PMID:25181051 and PMID:30816183 | bisphenol F | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of DDA1 mRNA | CTD | PMID:36041667 | carbon nanotube | increases expression | ISO | Dda1 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chlorpyrifos | increases expression | ISO | Dda1 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of DDA1 mRNA | CTD | PMID:37019170 | clofibrate | decreases expression | ISO | Dda1 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of DDA1 mRNA | CTD | PMID:17585979 | clofibrate | multiple interactions | ISO | Dda1 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of DDA1 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DDA1 mRNA] | CTD | PMID:17585979 | copper(II) sulfate | increases expression | ISO | DDA1 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of DDA1 mRNA | CTD | PMID:19549813 | dexamethasone | multiple interactions | ISO | DDA1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of DDA1 mRNA | CTD | PMID:28628672 | diazinon | increases methylation | ISO | DDA1 (Homo sapiens) | 6480464 | Diazinon results in increased methylation of DDA1 gene | CTD | PMID:22964155 | diethylstilbestrol | increases expression | ISO | Dda1 (Mus musculus) | 6480464 | Diethylstilbestrol results in increased expression of DDA1 mRNA | CTD | PMID:16636312 | dorsomorphin | multiple interactions | ISO | DDA1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDA1 mRNA | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | DDA1 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of DDA1 mRNA | CTD | PMID:29803840 | ethanol | affects expression | ISO | Dda1 (Mus musculus) | 6480464 | Ethanol affects the expression of DDA1 mRNA | CTD | PMID:30319688 | fenthion | decreases expression | ISO | Dda1 (Mus musculus) | 6480464 | Fenthion results in decreased expression of DDA1 mRNA | CTD | PMID:34813904 | folic acid | multiple interactions | ISO | Dda1 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of DDA1 mRNA] | CTD | PMID:22206623 | FR900359 | increases phosphorylation | ISO | DDA1 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of DDA1 protein | CTD | PMID:37730182 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of DDA1 mRNA | CTD | PMID:33387578 | glafenine | increases expression | EXP | | 6480464 | Glafenine results in increased expression of DDA1 mRNA | CTD | PMID:24136188 | hydrogen cyanide | decreases expression | ISO | Dda1 (Mus musculus) | 6480464 | Hydrogen Cyanide results in decreased expression of DDA1 mRNA | CTD | PMID:33914522 | indometacin | multiple interactions | ISO | DDA1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of DDA1 mRNA | CTD | PMID:28628672 | methotrexate | increases expression | ISO | DDA1 (Homo sapiens) | 6480464 | Methotrexate results in increased expression of DDA1 mRNA | CTD | PMID:24449571 | paracetamol | affects expression | ISO | Dda1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of DDA1 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of DDA1 mRNA | CTD | PMID:33387578 | paracetamol | multiple interactions | ISO | Dda1 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of DDA1 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DDA1 mRNA] | CTD | PMID:17585979 | phenylmercury acetate | increases expression | ISO | DDA1 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of DDA1 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | DDA1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDA1 mRNA | CTD | PMID:27188386 | pirinixic acid | multiple interactions | ISO | DDA1 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DDA1 mRNA | CTD | PMID:19710929 | potassium cyanide | increases expression | ISO | Dda1 (Mus musculus) | 6480464 | Potassium Cyanide results in increased expression of DDA1 mRNA | CTD | PMID:33914522 | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of DDA1 mRNA | CTD | PMID:30047161 | rac-lactic acid | decreases expression | ISO | DDA1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of DDA1 mRNA | CTD | PMID:30851411 | resveratrol | multiple interactions | ISO | DDA1 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of DDA1 mRNA | CTD | PMID:23557933 | SB 431542 | multiple interactions | ISO | DDA1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDA1 mRNA | CTD | PMID:27188386 | sulfadimethoxine | increases expression | EXP | | 6480464 | Sulfadimethoxine results in increased expression of DDA1 mRNA | CTD | PMID:30047161 | temozolomide | increases expression | ISO | DDA1 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of DDA1 mRNA | CTD | PMID:31758290 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of DDA1 mRNA | CTD | PMID:34492290 | triptonide | increases expression | ISO | Dda1 (Mus musculus) | 6480464 | triptonide results in increased expression of DDA1 mRNA | CTD | PMID:33045310 | valproic acid | decreases methylation | ISO | DDA1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of DDA1 gene | CTD | PMID:29154799 | valproic acid | increases expression | ISO | DDA1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of DDA1 mRNA | CTD | PMID:23179753 | |