Ppp1r3e (protein phosphatase 1, regulatory subunit 3E) - Rat Genome Database

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Gene: Ppp1r3e (protein phosphatase 1, regulatory subunit 3E) Rattus norvegicus
Analyze
Symbol: Ppp1r3e
Name: protein phosphatase 1, regulatory subunit 3E
RGD ID: 1583926
Description: Enables [phosphorylase] phosphatase activity. Contributes to phosphoprotein phosphatase activity. Involved in positive regulation of glycogen biosynthetic process and regulation of glycogen catabolic process. Located in glycogen granule. Orthologous to human PPP1R3E (protein phosphatase 1 regulatory subunit 3E); PARTICIPATES IN glycogen biosynthetic pathway; glycogen degradation pathway; INTERACTS WITH bisphenol A; (-)-demecolcine (ortholog); 2-hydroxypropanoic acid (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC691447; protein phosphatase 1 regulatory subunit 3E; protein phosphatase 1, regulatory (inhibitor) subunit 3E; similar to Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1, regulatory subunit 6) (Protein phosphatase 1-binding subunit R6)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,318,435 - 32,319,595 (-)NCBIGRCr8
mRatBN7.21528,348,443 - 28,349,603 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,347,854 - 28,349,603 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,194,105 - 30,195,265 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,341,307 - 31,342,467 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,584,033 - 29,585,193 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,535,986 - 33,537,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,535,986 - 33,537,146 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,422,932 - 37,424,092 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41532,974,172 - 32,975,332 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1527,926,360 - 27,927,520 (-)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents. Munro S, etal., FEBS J. 2005 Mar;272(6):1478-89.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Ppp1r3e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,318,435 - 32,319,595 (-)NCBIGRCr8
mRatBN7.21528,348,443 - 28,349,603 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,347,854 - 28,349,603 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,194,105 - 30,195,265 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,341,307 - 31,342,467 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,584,033 - 29,585,193 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,535,986 - 33,537,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,535,986 - 33,537,146 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,422,932 - 37,424,092 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41532,974,172 - 32,975,332 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1527,926,360 - 27,927,520 (-)NCBICelera
Cytogenetic Map15p13NCBI
PPP1R3E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,295,652 - 23,302,859 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,295,652 - 23,302,859 (-)EnsemblGRCh38hg38GRCh38
GRCh371423,764,861 - 23,772,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,832,901 - 22,841,835 (-)NCBINCBI36Build 36hg18NCBI36
Celera143,627,819 - 3,634,764 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,881,804 - 3,888,734 (-)NCBIHuRef
CHM1_11423,763,798 - 23,770,725 (-)NCBICHM1_1
T2T-CHM13v2.01417,496,654 - 17,503,863 (-)NCBIT2T-CHM13v2.0
Ppp1r3e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,113,054 - 55,114,995 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,110,126 - 55,115,007 (-)EnsemblGRCm39 Ensembl
GRCm381454,875,597 - 54,877,538 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,872,669 - 54,877,550 (-)EnsemblGRCm38mm10GRCm38
MGSCv371455,494,434 - 55,496,375 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361453,829,802 - 53,833,887 (-)NCBIMGSCv36mm8
Celera1452,681,503 - 52,683,444 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1427.97NCBI
Ppp1r3e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540937,022,140 - 37,023,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540937,016,851 - 37,025,125 (+)NCBIChiLan1.0ChiLan1.0
PPP1R3E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21524,731,153 - 24,734,892 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11423,947,911 - 23,951,382 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,118,827 - 4,122,294 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11422,210,106 - 22,217,167 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,215,635 - 22,216,794 (-)Ensemblpanpan1.1panPan2
PPP1R3E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,559,296 - 3,564,849 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,563,457 - 3,564,524 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,507,425 - 3,513,188 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.083,666,878 - 3,672,635 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,671,247 - 3,672,314 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,358,489 - 3,364,245 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,419,802 - 3,425,549 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,681,735 - 3,687,492 (-)NCBIUU_Cfam_GSD_1.0
Ppp1r3e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864035,322,381 - 35,325,751 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367221,063,576 - 1,066,617 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367221,062,669 - 1,066,611 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R3E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,776,720 - 75,780,649 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,770,813 - 75,782,717 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,960,919 - 80,970,099 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R3E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,671,906 - 23,675,340 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,673,995 - 23,675,136 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605922,743,548 - 22,750,342 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r3e
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248209,248,989 - 9,252,604 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248209,246,477 - 9,255,803 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:128
Count of miRNA genes:100
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000019992
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 14 23 7 19 7 4 5 62 15 26 10 4
Below cutoff 3 27 32 32 32 4 6 12 20 12 1 4

Sequence


RefSeq Acc Id: ENSRNOT00000019992   ⟹   ENSRNOP00000019992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1528,347,854 - 28,349,603 (-)Ensembl
Rnor_6.0 Ensembl1533,535,986 - 33,537,146 (-)Ensembl
RefSeq Acc Id: NM_001169575   ⟹   NP_001163046
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,318,435 - 32,319,595 (-)NCBI
mRatBN7.21528,348,443 - 28,349,603 (-)NCBI
Rnor_6.01533,535,986 - 33,537,146 (-)NCBI
Rnor_5.01537,422,932 - 37,424,092 (-)NCBI
RGSC_v3.41532,974,172 - 32,975,332 (-)RGD
Celera1527,926,360 - 27,927,520 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001163046 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019992
  ENSRNOP00000019992.3
GenBank Protein P0C7L8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001163046   ⟸   NM_001169575
- UniProtKB: P0C7L8 (UniProtKB/Swiss-Prot),   F1LRU5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019992   ⟸   ENSRNOT00000019992
Protein Domains
CBM21

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C7L8-F1-model_v2 AlphaFold P0C7L8 1-279 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583926 AgrOrtholog
BioCyc Gene G2FUF-13769 BioCyc
Ensembl Genes ENSRNOG00000014904 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019992 ENTREZGENE
  ENSRNOT00000019992.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.2440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CBM21_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBM21_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:691447 UniProtKB/TrEMBL
NCBI Gene 691447 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CBM_21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppp1r3e PhenoGen
PROSITE CBM21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014904 RatGTEx
UniProt F1LRU5 ENTREZGENE, UniProtKB/TrEMBL
  P0C7L8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-18 Ppp1r3e  protein phosphatase 1, regulatory subunit 3E  Ppp1r3e  protein phosphatase 1, regulatory (inhibitor) subunit 3E  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Ppp1r3e  protein phosphatase 1, regulatory (inhibitor) subunit 3E  LOC691447  similar to Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1, regulatory subunit 6) (Protein phosphatase 1-binding subunit R6)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC691447  similar to Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1, regulatory subunit 6) (Protein phosphatase 1-binding subunit R6)  LOC679113  similar to Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1, regulatory subunit 6) (Protein phosphatase 1-binding subunit R6)  Data merged from RGD:1591879 1643240 APPROVED
2006-11-20 LOC679113  similar to Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1, regulatory subunit 6) (Protein phosphatase 1-binding subunit R6)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC691447  similar to Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1, regulatory subunit 6) (Protein phosphatase 1-binding subunit R6)      Symbol and Name status set to provisional 70820 PROVISIONAL