Zfp469 (zinc finger protein 469) - Rat Genome Database

Name: Zfp469
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Zfp469 (zinc finger protein 469) Rattus norvegicus

Analyze

Symbol:

Zfp469

Name:

zinc finger protein 469

RGD ID:

1583874

Description:

Predicted to be involved in regulation of extracellular matrix organization. Predicted to act upstream of or within several processes, including extracellular matrix organization; negative regulation of transcription by RNA polymerase II; and substantia propria of cornea development. Human ortholog(s) of this gene implicated in brittle cornea syndrome 1. Orthologous to human ZNF469 (zinc finger protein 469); INTERACTS WITH 17beta-estradiol; bisphenol A; 1-chloro-2,4-dinitrobenzene (ortholog).

Type:

protein-coding

RefSeq Status:

INFERRED

Previously known as:

LOC691499; similar to Zinc finger protein 469; Zfp469-ps1; zinc finger protein 469, pseudogene 1; Znf469; Znf469-ps1

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	19	50,282,434 - 50,324,010 (+)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	19	57,075,429 - 57,117,094 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	19	57,757,281 - 57,798,955 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	19	59,974,031 - 60,015,706 (+)	NCBI	Rnor_WKY
Rnor_6.0	19	54,843,864 - 55,083,935 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	19	65,758,945 - 65,800,160 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	52,474,513 - 52,514,139 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	19	49,329,658 - 49,566,287 (+)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

16Q24.3 Microdeletion Syndrome (ISO)

autosomal recessive chronic granulomatous disease 4 (ISO)

Brittle Cornea Syndrome (ISO)

brittle cornea syndrome 1 (ISO)

CARBONIC ANHYDRASE VA DEFICIENCY, HYPERAMMONEMIA DUE TO (ISO)

connective tissue disease (ISO)

corneal disease (ISO)

Ehlers-Danlos syndrome (ISO)

Fanconi anemia complementation group A (ISO)

gastroesophageal reflux disease (ISO)

genetic disease (ISO)

Joint Instability (ISO)

KBG syndrome (ISO)

keratoconus (ISO)

Keratoconus 1 (ISO)

myopia (ISO)

primary ciliary dyskinesia 33 (ISO)

Skin Abnormalities (ISO)

Striae Distensae (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-chloro-2,4-dinitrobenzene (ISO)

17beta-estradiol (EXP,ISO)

all-trans-retinoic acid (ISO)

antimycin A (ISO)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP)

butanal (ISO)

calcitriol (ISO)

cisplatin (ISO)

doxorubicin (ISO)

formaldehyde (ISO)

genistein (ISO)

paracetamol (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell-matrix adhesion (ISO)

collagen fibril organization (ISO)

establishment of localization in cell (ISO)

extracellular matrix constituent secretion (ISO)

fibroblast proliferation (ISO)

gene expression involved in extracellular matrix organization (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

regulation of extracellular matrix organization (ISO)

substantia propria of cornea development (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Zfp469
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	19	50,282,434 - 50,324,010 (+)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	19	57,075,429 - 57,117,094 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	19	57,757,281 - 57,798,955 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	19	59,974,031 - 60,015,706 (+)	NCBI	Rnor_WKY
Rnor_6.0	19	54,843,864 - 55,083,935 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	19	65,758,945 - 65,800,160 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	52,474,513 - 52,514,139 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	19	49,329,658 - 49,566,287 (+)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

ZNF469
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	88,100,931 - 88,440,753 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	16	88,382,959 - 88,440,757 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	88,449,367 - 88,507,161 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	87,021,380 - 87,034,666 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	16	73,564,290 - 73,577,602 (+)	NCBI		Celera
Cytogenetic Map	16	q24.2	NCBI
HuRef	16	74,187,210 - 74,200,522 (+)	NCBI		HuRef
CHM1_1	16	89,905,133 - 89,918,418 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	94,449,769 - 94,508,741 (+)	NCBI		T2T-CHM13v2.0

Zfp469
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	122,770,009 - 122,999,389 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	122,985,359 - 122,999,389 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	122,043,123 - 122,272,650 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	122,258,620 - 122,272,650 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	124,783,967 - 124,796,550 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	125,146,157 - 125,158,740 (+)	NCBI		MGSCv36	mm8
Celera	8	126,489,037 - 126,501,620 (+)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI

Znf469
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955541	2,404,549 - 2,438,183 (+)	NCBI	ChiLan1.0	ChiLan1.0

ZNF469
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	16	103,781,045 - 104,124,393 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	68,777,496 - 69,151,995 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	88,800,542 - 88,816,811 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	88,803,202 - 88,815,390 (+)	Ensembl	panpan1.1		panPan2

ZNF469
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	64,887,534 - 64,903,553 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	64,897,119 - 64,909,874 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	65,106,202 - 65,118,957 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	65,107,572 - 65,118,884 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	65,131,802 - 65,144,557 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	64,963,589 - 64,976,332 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	65,370,098 - 65,382,853 (-)	NCBI		UU_Cfam_GSD_1.0

Znf469
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	25,439,524 - 25,454,515 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936641	1,193,085 - 1,205,283 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ZNF469
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	1,162,822 - 1,174,257 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	1,161,514 - 1,208,406 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

ZNF469
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	73,762,456 - 73,820,262 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666047	1,866,974 - 1,926,024 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Znf469
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624746	1,043,117 - 1,074,776 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Zfp469
119 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	65
Count of miRNA genes:	60
Interacting mature miRNAs:	65
Transcripts:	ENSRNOT00000038203
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2187927	56457239	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	4096155	55283277	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	15455860	57337602	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	15630201	57337602	Rat
2298478	Eau8	Experimental allergic uveoretinitis QTL 8		0.0163	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	19	17154433	57337602	Rat
61350	Bp32	Blood pressure QTL 32		0.012	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	19	20483575	57337602	Rat
724546	Kidm3	Kidney mass QTL 3	3.1		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	19	29322490	57337602	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum insulin level (CMO:0000358)	19	33838214	55283146	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	19	33838214	55283146	Rat
5135224	Leukc1	Leukocyte quantity QTL 1			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	19	44340214	55283277	Rat
2313395	Anxrr26	Anxiety related response QTL 26			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	19	49976481	53225766	Rat

Markers in Region

D19Got111

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	50,300,071 - 50,300,243 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	55,060,310 - 55,060,477	NCBI	Rnor6.0
Rnor_5.0	19	65,776,535 - 65,776,702	UniSTS	Rnor5.0
RGSC_v3.4	19	52,491,531 - 52,491,698	UniSTS	RGSC3.4
Celera	19	49,542,354 - 49,542,521	UniSTS
Cytogenetic Map	19	q12	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001401088	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003753125	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772663	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008774252	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017587985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098197	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACYVU010000313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

XM_039098197 ⟹ XP_038954125

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	19	50,282,434 - 50,324,010 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001388017	(Get FASTA)	NCBI Sequence Viewer
	XP_038954125	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_038954125 ⟸ XM_039098197

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1583874	AgrOrtholog
BioCyc Gene	G2FUF-5407	BioCyc
NCBI Gene	691499	ENTREZGENE
PhenoGen	Zfp469	PhenoGen

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-03-07	Zfp469	zinc finger protein 469	Zfp469-ps1	zinc finger protein 469, pseudogene 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-11-27	Zfp469-ps1	zinc finger protein 469, pseudogene 1	Znf469-ps1	zinc finger protein 469, pseudogene 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-02-24	Znf469-ps1	zinc finger protein 469, pseudogene 1	Znf469	zinc finger protein 469	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-01-19	Znf469	zinc finger protein 469	LOC691499	similar to Zinc finger protein 469	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-01-09	LOC691499	similar to Zinc finger protein 469	LOC687587	similar to Zinc finger protein 469	Data Merged	1643240	APPROVED
2006-11-19	LOC691499	similar to Zinc finger protein 469			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC687587	similar to Zinc finger protein 469			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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