Unc93a (unc-93 homolog A) - Rat Genome Database

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Gene: Unc93a (unc-93 homolog A) Rattus norvegicus
Analyze
Symbol: Unc93a
Name: unc-93 homolog A
RGD ID: 1583290
Description: Predicted to be located in plasma membrane. Orthologous to human UNC93A (unc-93 homolog A); INTERACTS WITH bisphenol A; nitrofen; trichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC685007; similar to unc-93 homolog A; unc-93 homolog A (C. elegans)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8155,528,237 - 55,561,346 (-)NCBIGRCr8
mRatBN7.2152,973,143 - 53,029,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,980,724 - 53,029,663 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0153,572,734 - 53,593,535 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl153,573,128 - 53,589,844 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0154,820,357 - 54,837,749 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4147,636,147 - 47,645,658 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera148,740,244 - 48,760,961 (-)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12381271  


Genomics

Comparative Map Data
Unc93a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8155,528,237 - 55,561,346 (-)NCBIGRCr8
mRatBN7.2152,973,143 - 53,029,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,980,724 - 53,029,663 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0153,572,734 - 53,593,535 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl153,573,128 - 53,589,844 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0154,820,357 - 54,837,749 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4147,636,147 - 47,645,658 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera148,740,244 - 48,760,961 (-)NCBICelera
Cytogenetic Map1q12NCBI
UNC93A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386167,269,032 - 167,316,014 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6167,271,169 - 167,316,014 (+)EnsemblGRCh38hg38GRCh38
GRCh376167,704,803 - 167,729,502 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366167,624,891 - 167,649,491 (+)NCBINCBI36Build 36hg18NCBI36
Build 346167,675,311 - 167,699,912NCBI
Celera6168,447,509 - 168,472,228 (+)NCBICelera
Cytogenetic Map6q27NCBI
HuRef6165,177,338 - 165,201,977 (+)NCBIHuRef
CHM1_16167,967,196 - 167,991,677 (+)NCBICHM1_1
T2T-CHM13v2.06168,651,681 - 168,698,649 (+)NCBIT2T-CHM13v2.0
Unc93a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,327,504 - 13,362,553 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1713,327,504 - 13,350,697 (-)EnsemblGRCm39 Ensembl
GRCm381713,108,617 - 13,143,780 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1713,108,617 - 13,131,810 (-)EnsemblGRCm38mm10GRCm38
MGSCv371713,301,483 - 13,324,657 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,951,549 - 12,974,723 (-)NCBIMGSCv36mm8
Cytogenetic Map17A1NCBI
cM Map178.78NCBI
Unc93a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543914,783,277 - 14,824,802 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543914,783,644 - 14,823,585 (+)NCBIChiLan1.0ChiLan1.0
UNC93A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25187,522,712 - 187,546,654 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16185,416,087 - 185,440,675 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06165,158,007 - 165,181,841 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16170,256,537 - 170,280,251 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6170,256,712 - 170,279,696 (+)Ensemblpanpan1.1panPan2
UNC93A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1155,053,366 - 55,094,949 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl155,053,835 - 55,092,793 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha155,842,940 - 55,884,527 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0155,234,254 - 55,275,873 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl155,234,727 - 55,273,717 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1155,131,150 - 55,172,744 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0154,979,906 - 55,019,900 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0155,604,860 - 55,646,516 (-)NCBIUU_Cfam_GSD_1.0
Unc93a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946149,509,272 - 149,517,006 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648916,762,078 - 16,768,673 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UNC93A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl11,930,020 - 1,958,142 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.111,920,736 - 1,970,090 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213,101,447 - 3,126,111 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UNC93A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11395,147,079 - 95,171,401 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1395,147,728 - 95,170,952 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604066,987,992 - 67,010,283 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Unc93a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478512,053,233 - 12,083,980 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478512,053,233 - 12,083,983 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Unc93a
381 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:12
Count of miRNA genes:12
Interacting mature miRNAs:12
Transcripts:ENSRNOT00000073581
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 3 10 64 73 80 55 12 55 6 141 35 52 40 50 25

Sequence


Ensembl Acc Id: ENSRNOT00000073581   ⟹   ENSRNOP00000066381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl152,980,724 - 53,029,663 (-)Ensembl
Rnor_6.0 Ensembl153,573,128 - 53,589,844 (-)Ensembl
RefSeq Acc Id: NM_001427477   ⟹   NP_001414406
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8155,528,281 - 55,549,768 (-)NCBI
RefSeq Acc Id: XM_039099869   ⟹   XP_038955797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8155,528,237 - 55,561,346 (-)NCBI
mRatBN7.2152,973,143 - 53,016,018 (-)NCBI
RefSeq Acc Id: XM_039099878   ⟹   XP_038955806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8155,528,237 - 55,549,789 (-)NCBI
mRatBN7.2152,973,143 - 53,002,242 (-)NCBI
RefSeq Acc Id: XM_039099884   ⟹   XP_038955812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8155,528,237 - 55,542,019 (-)NCBI
mRatBN7.2152,973,143 - 52,994,494 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414406 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955797 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955806 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955812 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066381.2
Ensembl Acc Id: ENSRNOP00000066381   ⟸   ENSRNOT00000073581
RefSeq Acc Id: XP_038955797   ⟸   XM_039099869
- Peptide Label: isoform X1
- UniProtKB: M0RA42 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955806   ⟸   XM_039099878
- Peptide Label: isoform X1
- UniProtKB: M0RA42 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955812   ⟸   XM_039099884
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001414406   ⟸   NM_001427477
- UniProtKB: M0RA42 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RA42-F1-model_v2 AlphaFold M0RA42 1-457 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583290 AgrOrtholog
BioCyc Gene G2FUF-61498 BioCyc
Ensembl Genes ENSRNOG00000047027 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073581.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
InterPro Ion_channel_UNC-93 UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
  UNC-93_regulatory UniProtKB/TrEMBL
NCBI Gene 685007 ENTREZGENE
PANTHER PROTEIN UNC-93 HOMOLOG A UniProtKB/TrEMBL
  UNC-93 RELATED UniProtKB/TrEMBL
Pfam UNC-93 UniProtKB/TrEMBL
PhenoGen Unc93a PhenoGen
RatGTEx ENSRNOG00000047027 RatGTEx
Superfamily-SCOP MFS_gen_substrate_transporter UniProtKB/TrEMBL
UniProt M0RA42 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Unc93a  unc-93 homolog A  Unc93a  unc-93 homolog A (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-13 Unc93a  unc-93 homolog A (C. elegans)  LOC685007  similar to unc-93 homolog A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC685007  similar to unc-93 homolog A      Symbol and Name status set to provisional 70820 PROVISIONAL