Map3k19 (mitogen-activated protein kinase kinase kinase 19) - Rat Genome Database

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Gene: Map3k19 (mitogen-activated protein kinase kinase kinase 19) Rattus norvegicus
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Symbol: Map3k19
Name: mitogen-activated protein kinase kinase kinase 19
RGD ID: 1566400
Description: Predicted to enable ATP binding activity. Orthologous to human MAP3K19 (mitogen-activated protein kinase kinase kinase 19); INTERACTS WITH Cuprizon; fenvalerate; 1,2-dichloroethane (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AABR07020879.1; LOC289001; RGD1566400; similar to hypothetical protein FLJ23074; Ysk4; YSK4 Sps1/Ste20-related kinase homolog; YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81341,852,633 - 41,896,078 (-)NCBIGRCr8
mRatBN7.21339,300,150 - 39,343,502 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1339,300,163 - 39,343,767 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01344,524,055 - 44,553,197 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1344,523,797 - 44,540,516 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01349,608,805 - 49,636,322 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41340,461,978 - 40,490,269 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1339,675,906 - 39,718,072 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations

Genomics

Comparative Map Data
Map3k19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81341,852,633 - 41,896,078 (-)NCBIGRCr8
mRatBN7.21339,300,150 - 39,343,502 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1339,300,163 - 39,343,767 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01344,524,055 - 44,553,197 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1344,523,797 - 44,540,516 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01349,608,805 - 49,636,322 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41340,461,978 - 40,490,269 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1339,675,906 - 39,718,072 (-)NCBICelera
Cytogenetic Map13q13NCBI
MAP3K19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382134,964,491 - 135,047,447 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2134,964,485 - 135,047,468 (-)EnsemblGRCh38hg38GRCh38
GRCh372135,722,061 - 135,805,017 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362135,438,743 - 135,498,718 (-)NCBINCBI36Build 36hg18NCBI36
Celera2129,435,196 - 129,495,171 (-)NCBICelera
Cytogenetic Map2q21.3NCBI
HuRef2127,713,966 - 127,773,940 (-)NCBIHuRef
CHM1_12135,727,140 - 135,787,128 (-)NCBICHM1_1
T2T-CHM13v2.02135,404,909 - 135,487,908 (-)NCBIT2T-CHM13v2.0
Map3k19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391127,741,217 - 127,782,763 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1127,742,528 - 127,782,768 (-)EnsemblGRCm39 Ensembl
GRCm381127,813,480 - 127,855,026 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1127,814,791 - 127,855,031 (-)EnsemblGRCm38mm10GRCm38
MGSCv371129,711,848 - 129,736,867 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361129,642,846 - 129,680,189 (-)NCBIMGSCv36mm8
Celera1130,456,718 - 130,481,749 (-)NCBICelera
Cytogenetic Map1E3NCBI
cM Map155.8NCBI
Map3k19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554402,474,241 - 2,533,177 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554402,473,939 - 2,533,171 (-)NCBIChiLan1.0ChiLan1.0
MAP3K19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21339,879,254 - 39,967,928 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B39,894,521 - 39,980,519 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B24,810,581 - 24,896,288 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B139,040,441 - 139,100,334 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B139,040,449 - 139,100,334 (-)Ensemblpanpan1.1panPan2
MAP3K19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11937,791,019 - 37,826,505 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1937,791,861 - 37,845,208 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1938,031,515 - 38,050,213 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01939,236,831 - 39,255,523 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1939,236,833 - 39,295,925 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11937,879,273 - 37,897,970 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01938,040,233 - 38,058,950 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01939,275,412 - 39,294,120 (-)NCBIUU_Cfam_GSD_1.0
Map3k19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303100,821,201 - 100,877,053 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646940,746,063 - 40,796,026 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646940,757,248 - 40,796,297 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1516,911,115 - 16,973,980 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11516,911,117 - 16,976,598 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21519,367,704 - 19,422,702 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11019,191,469 - 19,271,547 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660613,225,703 - 3,310,488 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k19
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473234,359,557 - 34,429,259 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map3k19
210 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:80
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000005244
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133039535141184251Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
2292232Pur16Proteinuria QTL 1617.2urine total protein amount (VT:0000032)urine protein level (CMO:0000591)133615572341961389Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat


Expression


Sequence


Ensembl Acc Id: ENSRNOT00000005244   ⟹   ENSRNOP00000005244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1339,300,163 - 39,343,767 (-)Ensembl
RefSeq Acc Id: XM_039091284   ⟹   XP_038947212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81341,852,633 - 41,896,078 (-)NCBI
mRatBN7.21339,300,150 - 39,343,502 (-)NCBI
RefSeq Acc Id: XR_010056991
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81341,852,633 - 41,896,078 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038947212 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005244.7
RefSeq Acc Id: XP_038947212   ⟸   XM_039091284
- UniProtKB: F1LVM0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000005244   ⟸   ENSRNOT00000005244
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LVM0-F1-model_v2 AlphaFold F1LVM0 1-1216 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566400 AgrOrtholog
BioCyc Gene G2FUF-18431 BioCyc
Ensembl Genes ENSRNOG00000003952 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005244.7 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase_kinase_kinase UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene 289001 ENTREZGENE
PANTHER MAP KINASE KINASE KINASE SSK2-RELATED-RELATED UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Map3k19 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003952 RatGTEx
SMART ANK UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt F1LVM0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Map3k19  mitogen-activated protein kinase kinase kinase 19  AABR07020879.1    Data merged from RGD:15003270 737654 PROVISIONAL
2019-11-08 AABR07020879.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2012-10-24 Map3k19  mitogen-activated protein kinase kinase kinase 19  Ysk4  YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-12 Ysk4  YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)  RGD1566400  similar to hypothetical protein FLJ23074  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1566400  similar to hypothetical protein FLJ23074   RGD1566400_predicted  similar to hypothetical protein FLJ23074 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1566400_predicted  similar to hypothetical protein FLJ23074 (predicted)  LOC289001  similar to hypothetical protein FLJ23074  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC289001  similar to hypothetical protein FLJ23074      Symbol and Name status set to provisional 70820 PROVISIONAL