Mmgt1 (membrane magnesium transporter 1) - Rat Genome Database

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Gene: Mmgt1 (membrane magnesium transporter 1) Rattus norvegicus
Analyze
Symbol: Mmgt1
Name: membrane magnesium transporter 1
RGD ID: 1566339
Description: Predicted to enable cobalt ion transmembrane transporter activity; ferrous iron transmembrane transporter activity; and magnesium ion transmembrane transporter activity. Predicted to contribute to membrane insertase activity. Predicted to be involved in magnesium ion transport; protein insertion into ER membrane by stop-transfer membrane-anchor sequence; and tail-anchored membrane protein insertion into ER membrane. Predicted to act upstream of or within cobalt ion transport; copper ion transport; and iron ion transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of EMC complex. Predicted to be active in Golgi apparatus; early endosome; and plasma membrane. Orthologous to human MMGT1 (membrane magnesium transporter 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ER membrane protein complex subunit 5; LOC302864; RGD1566339; similar to transmembrane protein 32; Tmem32; transmembrane protein 32
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X134,408,463 - 134,420,798 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX134,408,466 - 134,420,729 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX136,605,407 - 136,617,742 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X140,159,968 - 140,172,303 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X137,729,350 - 137,741,685 (-)NCBIRnor_WKY
Rnor_6.0X158,966,694 - 158,978,995 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX158,966,673 - 158,978,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X153,597,936 - 153,610,237 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X141,123,953 - 141,136,288 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX142,458,978 - 142,471,313 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
early endosome  (IBA,ISO,ISS)
early endosome membrane  (IEA)
EMC complex  (IBA,IEA,ISO,ISS)
endoplasmic reticulum membrane  (ISO,ISS)
Golgi apparatus  (IBA,ISO,ISS)
Golgi membrane  (IEA)
membrane  (ISO,ISS)
plasma membrane  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:18057121   PMID:19946888   PMID:22119785  


Genomics

Comparative Map Data
Mmgt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X134,408,463 - 134,420,798 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX134,408,466 - 134,420,729 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX136,605,407 - 136,617,742 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X140,159,968 - 140,172,303 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X137,729,350 - 137,741,685 (-)NCBIRnor_WKY
Rnor_6.0X158,966,694 - 158,978,995 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX158,966,673 - 158,978,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X153,597,936 - 153,610,237 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X141,123,953 - 141,136,288 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX142,458,978 - 142,471,313 (-)NCBICelera
Cytogenetic MapXq37NCBI
MMGT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X135,960,588 - 135,973,988 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX135,960,588 - 135,974,029 (-)EnsemblGRCh38hg38GRCh38
GRCh37X135,042,747 - 135,056,147 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X134,871,897 - 134,883,800 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X134,769,750 - 134,781,654NCBI
CeleraX135,404,702 - 135,416,609 (-)NCBICelera
Cytogenetic MapXq26.3NCBI
HuRefX124,318,172 - 124,329,831 (-)NCBIHuRef
CHM1_1X134,955,293 - 134,967,204 (-)NCBICHM1_1
T2T-CHM13v2.0X134,269,310 - 134,282,721 (-)NCBIT2T-CHM13v2.0
Mmgt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X55,630,872 - 55,643,304 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX55,630,872 - 55,643,429 (-)EnsemblGRCm39 Ensembl
GRCm38X56,585,512 - 56,597,944 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX56,585,512 - 56,598,069 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X53,838,689 - 53,851,096 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X52,932,296 - 52,944,703 (-)NCBIMGSCv36mm8
CeleraX43,067,520 - 43,079,927 (-)NCBICelera
Cytogenetic MapXA5NCBI
Mmgt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554899,086,506 - 9,096,746 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554899,086,494 - 9,133,374 (+)NCBIChiLan1.0ChiLan1.0
MMGT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1X135,378,913 - 135,391,079 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X125,086,169 - 125,098,878 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X135,354,785 - 135,366,838 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX135,354,785 - 135,366,836 (-)Ensemblpanpan1.1panPan2
MMGT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X106,388,286 - 106,399,166 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX92,208,405 - 92,219,240 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X108,365,094 - 108,375,929 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X105,502,517 - 105,513,352 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X107,686,189 - 107,697,025 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X107,334,890 - 107,345,725 (-)NCBIUU_Cfam_GSD_1.0
Mmgt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X104,375,461 - 104,385,288 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651311,229,506 - 11,239,525 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493651311,229,354 - 11,239,152 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMGT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX111,144,233 - 111,158,335 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X111,145,712 - 111,158,298 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X127,067,831 - 127,080,417 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMGT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X110,976,376 - 110,986,917 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606548,640,974 - 48,652,825 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmgt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480811,174,966 - 11,196,288 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mmgt1
19 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:25
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000001179
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

Markers in Region
RH139598  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X134,408,587 - 134,408,776 (+)MAPPERmRatBN7.2
mRatBN7.21223,365,706 - 223,365,895 (+)MAPPERmRatBN7.2
Rnor_6.01243,712,210 - 243,712,398NCBIRnor6.0
Rnor_6.0X158,966,819 - 158,967,007NCBIRnor6.0
Rnor_5.01250,968,338 - 250,968,526UniSTSRnor5.0
Rnor_5.0X153,598,061 - 153,598,249UniSTSRnor5.0
RGSC_v3.41229,158,926 - 229,159,114UniSTSRGSC3.4
RGSC_v3.4X141,124,078 - 141,124,266UniSTSRGSC3.4
CeleraX142,459,103 - 142,459,291UniSTS
Celera1220,565,742 - 220,565,930UniSTS
Cytogenetic MapXq36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 57 41 18 41 8 11 74 35 33 11 8
Low 2 1 7
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001179   ⟹   ENSRNOP00000001179
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX158,966,673 - 158,978,995 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102610   ⟹   ENSRNOP00000096751
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX134,408,466 - 134,418,674 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108706   ⟹   ENSRNOP00000093526
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX134,408,466 - 134,420,729 (-)Ensembl
RefSeq Acc Id: NM_001106970   ⟹   NP_001100440
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X134,408,463 - 134,420,798 (-)NCBI
Rnor_6.0X158,966,694 - 158,978,995 (-)NCBI
Rnor_5.0X153,597,936 - 153,610,237 (-)NCBI
RGSC_v3.4X141,123,953 - 141,136,288 (-)RGD
CeleraX142,458,978 - 142,471,313 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100440 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68927 (Get FASTA)   NCBI Sequence Viewer  
  B5DF51 (Get FASTA)   NCBI Sequence Viewer  
  EDL75147 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100440   ⟸   NM_001106970
- Peptide Label: precursor
- UniProtKB: B5DF51 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001179   ⟸   ENSRNOT00000001179
RefSeq Acc Id: ENSRNOP00000096751   ⟸   ENSRNOT00000102610
RefSeq Acc Id: ENSRNOP00000093526   ⟸   ENSRNOT00000108706

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DF51-F1-model_v2 AlphaFold B5DF51 1-131 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702067
Promoter ID:EPDNEW_R12591
Type:multiple initiation site
Name:Mmgt1_1
Description:membrane magnesium transporter 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X158,978,939 - 158,978,999EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566339 AgrOrtholog
BioCyc Gene G2FUF-920 BioCyc
Ensembl Genes ENSRNOG00000000881 Ensembl
  ENSRNOG00000065883 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000093526 ENTREZGENE
  ENSRNOP00000093526.1 UniProtKB/Swiss-Prot
  ENSRNOP00000096751.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000102610.1 UniProtKB/TrEMBL
  ENSRNOT00000108706 ENTREZGENE
  ENSRNOT00000108706.1 UniProtKB/Swiss-Prot
InterPro Magnesium_transport UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:302864 UniProtKB/Swiss-Prot
NCBI Gene 302864 ENTREZGENE
PANTHER ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5 UniProtKB/Swiss-Prot
  ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5 UniProtKB/TrEMBL
  PTHR21181 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MMgT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mmgt1 PhenoGen
UniProt A0A8I6ATW4_RAT UniProtKB/TrEMBL
  B5DF51 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-05-05 Mmgt1  membrane magnesium transporter 1  Tmem32  transmembrane protein 32  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tmem32  transmembrane protein 32   Tmem32_predicted  transmembrane protein 32 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Tmem32_predicted  transmembrane protein 32 (predicted)  RGD1566339_predicted  similar to transmembrane protein 32 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1566339_predicted  similar to transmembrane protein 32 (predicted)  LOC302864  similar to transmembrane protein 32  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302864  similar to transmembrane protein 32      Symbol and Name status set to provisional 70820 PROVISIONAL