Zfp874b (zinc finger protein 874b) - Rat Genome Database

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Gene: Zfp874b (zinc finger protein 874b) Rattus norvegicus
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Symbol: Zfp874b (Ensembl: RGD1566325)
Name: zinc finger protein 874b (Ensembl:similar to regulator of sex-limitation candidate 16)
RGD ID: 1566325
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF429 (zinc finger protein 429); INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AABR07001099.1; LOC498682; RGD1566325; similar to regulator of sex-limitation candidate 16; Zfp875; zinc finger protein 875
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8136,830,702 - 36,842,705 (-)NCBIGRCr8
mRatBN7.2135,002,321 - 35,014,324 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl135,002,321 - 35,033,216 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx134,865,276 - 34,875,598 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0140,856,120 - 40,866,442 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0135,030,879 - 35,041,206 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0137,878,484 - 37,912,592 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0139,258,046 - 39,319,656 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera133,572,666 - 33,606,556 (-)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Zfp874b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8136,830,702 - 36,842,705 (-)NCBIGRCr8
mRatBN7.2135,002,321 - 35,014,324 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl135,002,321 - 35,033,216 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx134,865,276 - 34,875,598 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0140,856,120 - 40,866,442 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0135,030,879 - 35,041,206 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0137,878,484 - 37,912,592 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0139,258,046 - 39,319,656 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera133,572,666 - 33,606,556 (-)NCBICelera
Cytogenetic Map1p11NCBI
Zfp874b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391367,619,632 - 67,634,360 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1367,619,632 - 67,632,377 (-)EnsemblGRCm39 Ensembl
GRCm381367,471,513 - 67,486,241 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1367,471,513 - 67,484,258 (-)EnsemblGRCm38mm10GRCm38
MGSCv371367,572,449 - 67,585,189 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361367,971,424 - 67,983,323 (-)NCBIMGSCv36mm8
MGSCv361364,959,145 - 64,969,879 (-)NCBIMGSCv36mm8
Cytogenetic Map13B3NCBI
cM Map1334.54NCBI

Variants

.
Variants in Zfp874b
18 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat

Markers in Region
RH137125  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2134,979,153 - 34,979,335 (+)MAPPERmRatBN7.2
Rnor_6.0137,853,573 - 37,853,754NCBIRnor6.0
Rnor_5.0139,234,979 - 39,235,160UniSTSRnor5.0
RGSC_v3.4175,201,229 - 5,201,410UniSTSRGSC3.4
Celera133,548,258 - 33,548,439UniSTS
Cytogenetic Map17p14UniSTS
RH139848  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2135,002,358 - 35,002,539 (+)MAPPERmRatBN7.2
Rnor_6.0137,876,678 - 37,876,858NCBIRnor6.0
Rnor_5.0139,258,084 - 39,258,264UniSTSRnor5.0
RGSC_v3.4175,224,434 - 5,224,614UniSTSRGSC3.4
Celera133,570,860 - 33,571,040UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000024149   ⟹   ENSRNOP00000024149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl135,002,321 - 35,014,322 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081054   ⟹   ENSRNOP00000071214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl135,005,033 - 35,014,322 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103505   ⟹   ENSRNOP00000093684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl135,002,321 - 35,025,024 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111066   ⟹   ENSRNOP00000078544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl135,020,480 - 35,033,216 (-)Ensembl
RefSeq Acc Id: NM_001346428   ⟹   NP_001333357
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,830,702 - 36,842,705 (-)NCBI
mRatBN7.2135,002,321 - 35,014,324 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001333357 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024149.5
  ENSRNOP00000071214.2
  ENSRNOP00000093684.1
RefSeq Acc Id: NP_001333357   ⟸   NM_001346428
- UniProtKB: F1LVW4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093684   ⟸   ENSRNOT00000103505
Ensembl Acc Id: ENSRNOP00000071214   ⟸   ENSRNOT00000081054
Ensembl Acc Id: ENSRNOP00000024149   ⟸   ENSRNOT00000024149
Ensembl Acc Id: ENSRNOP00000078544   ⟸   ENSRNOT00000111066
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LVW4-F1-model_v2 AlphaFold F1LVW4 1-445 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566325 AgrOrtholog
BioCyc Gene G2FUF-61845 BioCyc
Ensembl Genes ENSRNOG00000017963 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024149.6 UniProtKB/TrEMBL
  ENSRNOT00000081054.2 UniProtKB/TrEMBL
  ENSRNOT00000103505.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB UniProtKB/TrEMBL
  KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel_C2H2_ZnF UniProtKB/TrEMBL
  Znf-C2H2_11 UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
KEGG Report rno:498682 UniProtKB/TrEMBL
NCBI Gene 498682 ENTREZGENE
PANTHER KRAB DOMAIN C2H2 ZINC FINGER UniProtKB/TrEMBL
  KRAB DOMAIN-CONTAINING PROTEIN 5 UniProtKB/TrEMBL
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 384 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 672-RELATED UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_11 UniProtKB/TrEMBL
PhenoGen Zfp874b PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017963 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF109640 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A0G2JZW8_RAT UniProtKB/TrEMBL
  A0A8I6AJD3_RAT UniProtKB/TrEMBL
  B2GNF2_RAT UniProtKB/TrEMBL
  F1LVW4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-04-13 Zfp874b  zinc finger protein 874b  RGD1566325  similar to regulator of sex-limitation candidate 16  Name and Symbol changed 629549 APPROVED
2022-06-02 RGD1566325  similar to regulator of sex-limitation candidate 16  Zfp875  zinc finger protein 875  Data merged from RGD:15003460 737654 PROVISIONAL
2022-01-06 Zfp875  zinc finger protein 875  Zfp874b  zinc finger protein 874b  Symbol and/or name change 19259462 PROVISIONAL
2021-05-06 Zfp874b  zinc finger protein 874b  Zfp875  zinc finger protein 875  Symbol and/or name change 19259462 PROVISIONAL
2020-10-01 Zfp875  zinc finger protein 875  Zfp874b  zinc finger protein 874b  Name and Symbol changed 629549 APPROVED
2020-04-30 Zfp874b  zinc finger protein 874b  AABR07001099.1    Symbol and/or name change 19259462 PROVISIONAL
2019-11-08 AABR07001099.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2008-04-30 RGD1566325  similar to regulator of sex-limitation candidate 16   RGD1566325_predicted  similar to regulator of sex-limitation candidate 16 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1566325_predicted  similar to regulator of sex-limitation candidate 16 (predicted)  LOC498682  similar to regulator of sex-limitation candidate 16  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498682  similar to regulator of sex-limitation candidate 16      Symbol and Name status set to provisional 70820 PROVISIONAL