Tppp2 (tubulin polymerization-promoting protein family member 2) - Rat Genome Database

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Gene: Tppp2 (tubulin polymerization-promoting protein family member 2) Rattus norvegicus
Analyze
Symbol: Tppp2
Name: tubulin polymerization-promoting protein family member 2
RGD ID: 1566185
Description: Predicted to enable tubulin binding activity. Predicted to be involved in microtubule cytoskeleton organization; positive regulation of protein polymerization; and regulation of flagellated sperm motility. Predicted to be located in cytosol and sperm flagellum. Predicted to colocalize with microtubule. Orthologous to human TPPP2 (tubulin polymerization promoting protein family member 2); INTERACTS WITH bisphenol A; fenvalerate; lead nitrate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC498497; RGD1566185; similar to chromosome 14 open reading frame 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,087,457 - 27,090,869 (+)NCBIGRCr8
mRatBN7.21524,614,284 - 24,627,123 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,614,006 - 24,618,967 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,385,402 - 27,387,693 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,341,123 - 28,343,417 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,594,067 - 26,596,361 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,319,175 - 28,321,469 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,319,136 - 28,321,476 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01532,131,751 - 32,134,449 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,351,907 - 27,354,201 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1524,919,795 - 24,922,089 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
tubulin binding  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17105200   PMID:30680919  


Genomics

Comparative Map Data
Tppp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,087,457 - 27,090,869 (+)NCBIGRCr8
mRatBN7.21524,614,284 - 24,627,123 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,614,006 - 24,618,967 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,385,402 - 27,387,693 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,341,123 - 28,343,417 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,594,067 - 26,596,361 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,319,175 - 28,321,469 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,319,136 - 28,321,476 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01532,131,751 - 32,134,449 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,351,907 - 27,354,201 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1524,919,795 - 24,922,089 (+)NCBICelera
Cytogenetic Map15p14NCBI
TPPP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381421,024,299 - 21,036,352 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1421,024,109 - 21,036,276 (+)EnsemblGRCh38hg38GRCh38
GRCh371421,498,376 - 21,500,974 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,568,296 - 20,570,167 (+)NCBINCBI36Build 36hg18NCBI36
Build 341420,568,511 - 20,570,166NCBI
Celera141,359,208 - 1,361,197 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,619,284 - 1,621,273 (+)NCBIHuRef
CHM1_11421,500,454 - 21,502,443 (+)NCBICHM1_1
T2T-CHM13v2.01415,221,665 - 15,233,755 (+)NCBIT2T-CHM13v2.0
Tppp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391452,155,887 - 52,158,161 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1452,155,882 - 52,158,157 (+)EnsemblGRCm39 Ensembl
GRCm381451,918,430 - 51,920,704 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,918,425 - 51,920,700 (+)EnsemblGRCm38mm10GRCm38
MGSCv371452,538,436 - 52,540,375 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361450,840,376 - 50,842,651 (+)NCBIMGSCv36mm8
Celera1448,904,044 - 48,905,975 (+)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1426.72NCBI
Tppp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555501,779,375 - 1,785,575 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555501,779,405 - 1,785,385 (+)NCBIChiLan1.0ChiLan1.0
TPPP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,481,667 - 22,484,381 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,698,154 - 21,700,221 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,839,314 - 1,847,789 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11419,921,223 - 19,929,695 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,927,478 - 19,928,973 (+)Ensemblpanpan1.1panPan2
TPPP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11518,118,516 - 18,126,661 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1518,119,594 - 18,126,663 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1518,603,958 - 18,612,111 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01518,379,272 - 18,387,432 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1518,380,689 - 18,382,319 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11518,060,621 - 18,068,781 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01518,116,582 - 18,124,736 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01518,244,499 - 18,252,668 (+)NCBIUU_Cfam_GSD_1.0
Tppp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864032,320,929 - 32,323,163 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936880230,626 - 232,540 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936880230,626 - 232,540 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPPP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,105,215 - 78,110,405 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1778,106,126 - 78,108,570 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TPPP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,503,616 - 21,505,890 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2921,504,299 - 21,505,799 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605924,929,967 - 24,932,053 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tppp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248257,021,639 - 7,023,027 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248257,021,146 - 7,023,129 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tppp2
49 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:62
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000048723
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 11 45 102 73 68 41 18 41 6 173 86 82 31 59 27

Sequence


Ensembl Acc Id: ENSRNOT00000048723   ⟹   ENSRNOP00000048043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,614,006 - 24,617,346 (+)Ensembl
Rnor_6.0 Ensembl1528,319,136 - 28,321,476 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098524   ⟹   ENSRNOP00000080706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,614,006 - 24,618,967 (+)Ensembl
RefSeq Acc Id: NM_001109100   ⟹   NP_001102570
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,087,836 - 27,090,130 (+)NCBI
mRatBN7.21524,614,337 - 24,616,631 (+)NCBI
Rnor_6.01528,319,175 - 28,321,469 (+)NCBI
Rnor_5.01532,131,751 - 32,134,449 (+)NCBI
RGSC_v3.41527,351,907 - 27,354,201 (+)RGD
Celera1524,919,795 - 24,922,089 (+)RGD
Sequence:
RefSeq Acc Id: XM_039093586   ⟹   XP_038949514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,087,485 - 27,090,869 (+)NCBI
mRatBN7.21524,614,284 - 24,617,414 (+)NCBI
RefSeq Acc Id: XM_039093588   ⟹   XP_038949516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,087,503 - 27,090,869 (+)NCBI
mRatBN7.21524,614,367 - 24,617,500 (+)NCBI
RefSeq Acc Id: XM_039093589   ⟹   XP_038949517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,087,485 - 27,090,856 (+)NCBI
mRatBN7.21524,614,286 - 24,617,092 (+)NCBI
RefSeq Acc Id: XM_063274548   ⟹   XP_063130618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,087,457 - 27,090,124 (+)NCBI
RefSeq Acc Id: XM_063274549   ⟹   XP_063130619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,087,503 - 27,090,124 (+)NCBI
RefSeq Acc Id: NP_001102570   ⟸   NM_001109100
- UniProtKB: A6KEE8 (UniProtKB/TrEMBL),   A0A8I5ZRB0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000048043   ⟸   ENSRNOT00000048723
RefSeq Acc Id: XP_038949514   ⟸   XM_039093586
- Peptide Label: isoform X1
- UniProtKB: D3ZCE7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949517   ⟸   XM_039093589
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZRB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949516   ⟸   XM_039093588
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000080706   ⟸   ENSRNOT00000098524
RefSeq Acc Id: XP_063130618   ⟸   XM_063274548
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZRB0 (UniProtKB/TrEMBL),   A6KEE8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130619   ⟸   XM_063274549
- Peptide Label: isoform X5

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCE7-F1-model_v2 AlphaFold D3ZCE7 1-170 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566185 AgrOrtholog
BioCyc Gene G2FUF-14001 BioCyc
Ensembl Genes ENSRNOG00000025473 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048723.5 UniProtKB/TrEMBL
  ENSRNOT00000098524.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro EF-hand-like_dom UniProtKB/TrEMBL
  P25-alpha UniProtKB/TrEMBL
KEGG Report rno:498497 UniProtKB/TrEMBL
NCBI Gene 498497 ENTREZGENE
PANTHER P25-alpha UniProtKB/TrEMBL
  PTHR12932:SF21 UniProtKB/TrEMBL
Pfam p25-alpha UniProtKB/TrEMBL
PhenoGen Tppp2 PhenoGen
RatGTEx ENSRNOG00000025473 RatGTEx
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A8I5ZRB0 ENTREZGENE, UniProtKB/TrEMBL
  A6KEE8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCE7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Tppp2  tubulin polymerization-promoting protein family member 2  RGD1566185_predicted  similar to chromosome 14 open reading frame 8 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566185_predicted  similar to chromosome 14 open reading frame 8 (predicted)  LOC498497  similar to chromosome 14 open reading frame 8  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498497  similar to chromosome 14 open reading frame 8      Symbol and Name status set to provisional 70820 PROVISIONAL