Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-demecolcine | decreases expression | ISO | APEX2 (Homo sapiens) | 6480464 | Demecolcine results in decreased expression of APEX2 mRNA | CTD | PMID:23649840 | (1->4)-beta-D-glucan | multiple interactions | ISO | Apex2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of APEX2 mRNA | CTD | PMID:36331819 | (R,R,R)-alpha-tocopherol | decreases expression | EXP | | 6480464 | alpha-Tocopherol results in decreased expression of APEX2 mRNA | CTD | PMID:26332274 | (R,R,R)-alpha-tocopherol | multiple interactions | EXP | | 6480464 | alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA] | CTD | PMID:26332274 | 1,2-dimethylhydrazine | decreases expression | ISO | Apex2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of APEX2 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | affects expression | ISO | Apex2 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of APEX2 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | multiple interactions | ISO | Apex2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APEX2 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | ISO | Apex2 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of APEX2 mRNA | CTD | PMID:17942748 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Apex2 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:32352317 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Apex2 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Apex2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APEX2 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of APEX2 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Apex2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of APEX2 mRNA | CTD | PMID:24680724 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Apex2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of APEX2 mRNA | CTD | PMID:17942748 | 2-hydroxypropanoic acid | decreases expression | ISO | APEX2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of APEX2 mRNA | CTD | PMID:30851411 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Apex2 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of APEX2 mRNA | CTD | PMID:20188158 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of APEX2 mRNA | CTD | PMID:28959563 | acrylonitrile | multiple interactions | EXP | | 6480464 | Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA] more ... | CTD | PMID:26332274 | acrylonitrile | increases expression | EXP | | 6480464 | Acrylonitrile results in increased expression of APEX2 mRNA | CTD | PMID:26332274 | antirheumatic drug | decreases expression | ISO | APEX2 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of APEX2 mRNA | CTD | PMID:24449571 | arsane | affects expression | ISO | APEX2 (Homo sapiens) | 6480464 | Arsenic affects the expression of APEX2 mRNA | CTD | PMID:33736254 | arsane | multiple interactions | ISO | APEX2 (Homo sapiens) | 6480464 | [Palmitic Acid co-treated with Arsenic] affects the expression of APEX2 mRNA | CTD | PMID:33736254 | arsenic atom | affects expression | ISO | APEX2 (Homo sapiens) | 6480464 | Arsenic affects the expression of APEX2 mRNA | CTD | PMID:33736254 | arsenic atom | multiple interactions | ISO | APEX2 (Homo sapiens) | 6480464 | [Palmitic Acid co-treated with Arsenic] affects the expression of APEX2 mRNA | CTD | PMID:33736254 | benzo[a]pyrene | affects methylation | ISO | APEX2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of APEX2 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | ISO | APEX2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of APEX2 exon | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | increases expression | ISO | APEX2 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of APEX2 mRNA | CTD | PMID:25181051 more ... | bisphenol A | decreases expression | ISO | APEX2 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of APEX2 mRNA | CTD | PMID:33670352 | bisphenol A | decreases methylation | ISO | Apex2 (Mus musculus) | 6480464 | bisphenol A results in decreased methylation of APEX2 promoter | CTD | PMID:27312807 | CGP 52608 | multiple interactions | ISO | APEX2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to APEX2 gene] | CTD | PMID:28238834 | cobalt dichloride | decreases expression | ISO | APEX2 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of APEX2 mRNA | CTD | PMID:19320972 | copper(II) sulfate | increases expression | ISO | APEX2 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of APEX2 mRNA | CTD | PMID:19549813 | diazinon | affects expression | EXP | | 6480464 | Diazinon affects the expression of APEX2 mRNA | CTD | PMID:22546817 | dicrotophos | increases expression | ISO | APEX2 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of APEX2 mRNA | CTD | PMID:28302478 | dieldrin | affects expression | EXP | | 6480464 | Dieldrin affects the expression of APEX2 mRNA | CTD | PMID:22546817 | doxorubicin | decreases expression | ISO | APEX2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of APEX2 mRNA | CTD | PMID:29803840 | epoxiconazole | decreases expression | ISO | Apex2 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of APEX2 mRNA | CTD | PMID:35436446 | flutamide | decreases expression | ISO | Apex2 (Mus musculus) | 6480464 | Flutamide results in decreased expression of APEX2 mRNA | CTD | PMID:19442681 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of APEX2 mRNA | CTD | PMID:33387578 | glyphosate | decreases expression | ISO | APEX2 (Homo sapiens) | 6480464 | Glyphosate results in decreased expression of APEX2 mRNA | CTD | PMID:31295307 | hexadecanoic acid | multiple interactions | ISO | APEX2 (Homo sapiens) | 6480464 | [Palmitic Acid co-treated with Arsenic] affects the expression of APEX2 mRNA | CTD | PMID:33736254 | inulin | multiple interactions | ISO | Apex2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of APEX2 mRNA | CTD | PMID:36331819 | ketamine | decreases expression | EXP | | 6480464 | Ketamine results in decreased expression of APEX2 mRNA | CTD | PMID:20080153 | methamphetamine | increases expression | EXP | | 6480464 | Methamphetamine results in increased expression of APEX2 mRNA | CTD | PMID:19149911 | methyl methanesulfonate | increases expression | ISO | APEX2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of APEX2 mRNA | CTD | PMID:21527772 | N-acetyl-L-cysteine | multiple interactions | EXP | | 6480464 | Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA] | CTD | PMID:26332274 | N-acetyl-L-cysteine | decreases expression | EXP | | 6480464 | Acetylcysteine results in decreased expression of APEX2 mRNA | CTD | PMID:26332274 | nickel atom | increases expression | ISO | APEX2 (Homo sapiens) | 6480464 | Nickel results in increased expression of APEX2 mRNA | CTD | PMID:25583101 | nickel dichloride | affects expression | EXP | | 6480464 | nickel chloride affects the expression of APEX2 mRNA | CTD | PMID:22546817 | paracetamol | affects expression | ISO | Apex2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of APEX2 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | APEX2 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of APEX2 mRNA | CTD | PMID:22230336 and PMID:25704631 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Apex2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of APEX2 mRNA and [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of APEX2 mRNA | CTD | PMID:36331819 | phorbol 13-acetate 12-myristate | increases expression | ISO | APEX2 (Homo sapiens) | 6480464 | Tetradecanoylphorbol Acetate results in increased expression of APEX2 mRNA | CTD | PMID:19031421 | pirinixic acid | multiple interactions | ISO | Apex2 (Mus musculus) | 6480464 | NCF1 protein affects the reaction [pirinixic acid results in decreased expression of APEX2 mRNA] and PPARA protein promotes the reaction [pirinixic acid results in decreased expression of APEX2 mRNA] | CTD | PMID:17950772 | pirinixic acid | decreases expression | ISO | Apex2 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of APEX2 mRNA | CTD | PMID:17950772 | potassium dichromate | decreases expression | ISO | Apex2 (Mus musculus) | 6480464 | Potassium Dichromate results in decreased expression of APEX2 mRNA | CTD | PMID:23608068 | rac-lactic acid | decreases expression | ISO | APEX2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of APEX2 mRNA | CTD | PMID:30851411 | silver atom | decreases expression | ISO | Apex2 (Mus musculus) | 6480464 | Silver results in decreased expression of APEX2 mRNA | CTD | PMID:27131904 | silver(0) | decreases expression | ISO | Apex2 (Mus musculus) | 6480464 | Silver results in decreased expression of APEX2 mRNA | CTD | PMID:27131904 | sodium arsenite | increases expression | ISO | Apex2 (Mus musculus) | 6480464 | sodium arsenite results in increased expression of APEX2 mRNA | CTD | PMID:37682722 | tamoxifen | increases expression | ISO | APEX2 (Homo sapiens) | 6480464 | Tamoxifen results in increased expression of APEX2 mRNA | CTD | PMID:15590111 | tamoxifen | affects expression | ISO | Apex2 (Mus musculus) | 6480464 | Tamoxifen affects the expression of APEX2 mRNA | CTD | PMID:17555576 | temozolomide | increases expression | ISO | APEX2 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of APEX2 mRNA | CTD | PMID:31758290 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of APEX2 mRNA | CTD | PMID:34492290 | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of APEX2 mRNA | CTD | PMID:33387578 | Triptolide | affects expression | ISO | Apex2 (Mus musculus) | 6480464 | triptolide affects the expression of APEX2 mRNA | CTD | PMID:32835833 | triptonide | decreases expression | ISO | Apex2 (Mus musculus) | 6480464 | triptonide results in decreased expression of APEX2 mRNA | CTD | PMID:33045310 | troglitazone | decreases expression | ISO | APEX2 (Homo sapiens) | 6480464 | troglitazone results in decreased expression of APEX2 mRNA | CTD | PMID:19140230 | trovafloxacin | increases expression | ISO | Apex2 (Mus musculus) | 6480464 | trovafloxacin results in increased expression of APEX2 mRNA | CTD | PMID:35537566 | tunicamycin | decreases expression | ISO | APEX2 (Homo sapiens) | 6480464 | Tunicamycin results in decreased expression of APEX2 mRNA | CTD | PMID:22378314 | valproic acid | affects expression | ISO | Apex2 (Mus musculus) | 6480464 | Valproic Acid affects the expression of APEX2 mRNA | CTD | PMID:17963808 | valproic acid | decreases expression | ISO | Apex2 (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of APEX2 mRNA | CTD | PMID:20546886 | vincristine | decreases expression | ISO | APEX2 (Homo sapiens) | 6480464 | Vincristine results in decreased expression of APEX2 mRNA | CTD | PMID:23649840 | |