Arhgap36 (Rho GTPase activating protein 36) - Rat Genome Database

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Gene: Arhgap36 (Rho GTPase activating protein 36) Rattus norvegicus
Analyze
Symbol: Arhgap36
Name: Rho GTPase activating protein 36
RGD ID: 1565967
Description: Predicted to enable GTPase activator activity. Predicted to be involved in actin filament organization. Predicted to be located in cytoskeleton. Predicted to be active in actin cytoskeleton. Orthologous to human ARHGAP36 (Rho GTPase activating protein 36); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC302819; RGD1565967; rho GTPase-activating protein 36; similar to hypothetical protein FLJ30058
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X133,635,996 - 133,664,995 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX133,635,973 - 133,664,888 (+)EnsemblGRCr8
mRatBN7.2X128,780,148 - 128,787,169 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX128,751,900 - 128,787,161 (+)EnsemblmRatBN7.2
Rnor_6.0X136,460,227 - 136,495,646 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX136,460,215 - 136,495,646 (+)Ensemblrn6Rnor6.0
Rnor_5.0X136,531,392 - 136,560,308 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X135,979,352 - 136,007,067 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX127,686,135 - 127,721,538 (+)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Arhgap36
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X133,635,996 - 133,664,995 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX133,635,973 - 133,664,888 (+)EnsemblGRCr8
mRatBN7.2X128,780,148 - 128,787,169 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX128,751,900 - 128,787,161 (+)EnsemblmRatBN7.2
Rnor_6.0X136,460,227 - 136,495,646 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX136,460,215 - 136,495,646 (+)Ensemblrn6Rnor6.0
Rnor_5.0X136,531,392 - 136,560,308 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X135,979,352 - 136,007,067 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX127,686,135 - 127,721,538 (+)NCBICelera
Cytogenetic MapXq36NCBI
ARHGAP36
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X131,058,346 - 131,089,885 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX131,058,346 - 131,089,885 (+)Ensemblhg38GRCh38
GRCh37X130,192,320 - 130,223,859 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X130,019,897 - 130,051,534 (+)NCBIBuild 36Build 36hg18NCBI36
CeleraX130,578,656 - 130,610,299 (+)NCBICelera
Cytogenetic MapXq26.1NCBI
HuRefX119,585,675 - 119,616,405 (+)NCBIHuRef
CHM1_1X130,103,907 - 130,135,516 (+)NCBICHM1_1
T2T-CHM13v2.0X129,378,162 - 129,409,672 (+)NCBIT2T-CHM13v2.0
Arhgap36
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X48,537,237 - 48,589,121 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX48,552,822 - 48,589,121 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X49,448,360 - 49,500,244 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX49,463,945 - 49,500,244 (+)Ensemblmm10GRCm38
MGSCv37X46,823,627 - 46,853,427 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X45,715,077 - 45,744,877 (+)NCBIMGSCv36mm8
CeleraX36,935,292 - 36,965,492 (+)NCBICelera
Cytogenetic MapXA5NCBI
cM MapX25.95NCBI
Arhgap36
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554733,915,828 - 3,945,625 (-)Ensembl
ChiLan1.0NW_0049554733,914,769 - 3,922,938 (-)NCBIChiLan1.0ChiLan1.0
ARHGAP36
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X130,483,395 - 130,514,910 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X130,487,004 - 130,518,524 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X120,204,098 - 120,221,064 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X130,505,137 - 130,536,521 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX130,505,137 - 130,536,556 (+)EnsemblpanPan2panpan1.1
ARHGAP36
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X102,175,486 - 102,227,607 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX102,196,331 - 102,227,602 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX88,370,546 - 88,401,920 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X104,052,717 - 104,084,084 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX104,052,846 - 104,084,085 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X101,467,674 - 101,499,044 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X103,316,379 - 103,347,730 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X103,095,119 - 103,126,491 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arhgap36
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X100,387,747 - 100,417,507 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936479569,990 - 599,778 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936479569,990 - 599,778 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP36
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X107,368,552 - 107,537,747 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X123,522,079 - 123,553,599 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP36
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X106,300,640 - 106,332,161 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX106,323,850 - 106,332,186 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606543,722,135 - 43,753,630 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgap36
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479710,525,742 - 10,555,311 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462479710,501,785 - 10,556,394 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgap36
123 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:43
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000068717
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X120028026141353710Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X120028026141353710Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118973754157758123Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat

Markers in Region
1100001E04Rik  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X133,662,042 - 133,662,309 (+)Marker Load Pipeline
mRatBN7.2X128,784,216 - 128,784,483 (+)MAPPERmRatBN7.2
Rnor_6.0X136,492,694 - 136,492,960NCBIRnor6.0
Rnor_5.0X136,557,356 - 136,557,622UniSTSRnor5.0
RGSC_v3.4X136,005,223 - 136,005,489UniSTSRGSC3.4
CeleraX127,718,586 - 127,718,852UniSTS
Cytogenetic MapXq36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
5 8 19 123 56 42 28 15 28 6 135 56 103 40 58 14 8 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001432931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001069533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_229133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000068717   ⟹   ENSRNOP00000059401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX133,635,973 - 133,663,887 (+)Ensembl
mRatBN7.2 EnsemblX128,758,336 - 128,786,061 (+)Ensembl
Rnor_6.0 EnsemblX136,466,825 - 136,494,538 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093183   ⟹   ENSRNOP00000076160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX136,476,823 - 136,491,047 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093268   ⟹   ENSRNOP00000076129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX128,777,697 - 128,787,161 (+)Ensembl
Rnor_6.0 EnsemblX136,466,779 - 136,491,037 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093432   ⟹   ENSRNOP00000076115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX136,488,691 - 136,491,310 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093538   ⟹   ENSRNOP00000076304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX133,635,973 - 133,664,888 (+)Ensembl
mRatBN7.2 EnsemblX128,751,900 - 128,787,161 (+)Ensembl
Rnor_6.0 EnsemblX136,460,215 - 136,495,646 (+)Ensembl
RefSeq Acc Id: XM_063280532   ⟹   XP_063136602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X133,655,564 - 133,664,995 (+)NCBI
RefSeq Acc Id: XM_063280533   ⟹   XP_063136603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X133,636,006 - 133,664,995 (+)NCBI
RefSeq Acc Id: XM_229133   ⟹   XP_229133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X133,635,996 - 133,664,995 (+)NCBI
mRatBN7.2X128,780,148 - 128,787,169 (+)NCBI
Rnor_6.0X136,466,684 - 136,495,646 (+)NCBI
Rnor_5.0X136,531,392 - 136,560,308 (+)NCBI
RGSC_v3.4X135,979,352 - 136,007,067 (+)RGD
Sequence:
RefSeq Acc Id: XP_229133   ⟸   XM_229133
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000076304   ⟸   ENSRNOT00000093538
Ensembl Acc Id: ENSRNOP00000059401   ⟸   ENSRNOT00000068717
Ensembl Acc Id: ENSRNOP00000076115   ⟸   ENSRNOT00000093432
Ensembl Acc Id: ENSRNOP00000076160   ⟸   ENSRNOT00000093183
Ensembl Acc Id: ENSRNOP00000076129   ⟸   ENSRNOT00000093268
RefSeq Acc Id: XP_063136603   ⟸   XM_063280533
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063136602   ⟸   XM_063280532
- Peptide Label: isoform X2
Protein Domains
Rho-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M6E2-F1-model_v2 AlphaFold F1M6E2 1-588 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565967 AgrOrtholog
BioCyc Gene G2FUF-1117 BioCyc
Ensembl Genes ENSRNOG00000007552 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068717.3 UniProtKB/TrEMBL
  ENSRNOT00000093268.2 UniProtKB/TrEMBL
  ENSRNOT00000093538 ENTREZGENE
  ENSRNOT00000093538.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
InterPro ARHGAP6_RhoGAP UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RHOGAP6/36 UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
NCBI Gene 302819 ENTREZGENE
PANTHER PTHR12635 UniProtKB/TrEMBL
  RHO GTPASE-ACTIVATING PROTEIN 36 UniProtKB/TrEMBL
Pfam RhoGAP UniProtKB/TrEMBL
PhenoGen Arhgap36 PhenoGen
PROSITE RHOGAP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007552 RatGTEx
SMART RhoGAP UniProtKB/TrEMBL
Superfamily-SCOP Rho_GAP UniProtKB/TrEMBL
UniProt A0A1W2Q650 ENTREZGENE, UniProtKB/TrEMBL
  A0A1W2Q6M1 ENTREZGENE, UniProtKB/TrEMBL
  F1M6E2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-05-25 Arhgap36  Rho GTPase activating protein 36   RGD1565967  similar to hypothetical protein FLJ30058  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565967  similar to hypothetical protein FLJ30058   RGD1565967_predicted  similar to hypothetical protein FLJ30058 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565967_predicted  similar to hypothetical protein FLJ30058 (predicted)  LOC302819  similar to hypothetical protein FLJ30058  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302819  similar to hypothetical protein FLJ30058      Symbol and Name status set to provisional 70820 PROVISIONAL