Las1l (LAS1-like, ribosome biogenesis factor) - Rat Genome Database

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Gene: Las1l (LAS1-like, ribosome biogenesis factor) Rattus norvegicus
Analyze
Symbol: Las1l
Name: LAS1-like, ribosome biogenesis factor
RGD ID: 1565755
Description: Predicted to enable endonuclease activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Predicted to be located in nucleolus. Predicted to be part of MLL1 complex and preribosome, large subunit precursor. Human ortholog(s) of this gene implicated in Wilson-Turner syndrome. Orthologous to human LAS1L (LAS1 like ribosome biogenesis factor); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LAS1-like; LAS1-like (S. cerevisiae); LOC296865; MGC189399; RGD1565755; ribosomal biogenesis protein LAS1L
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X64,861,472 - 64,883,221 (-)NCBIGRCr8
mRatBN7.2X60,851,969 - 60,873,717 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX60,851,962 - 60,873,687 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX62,324,346 - 62,345,992 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X65,824,867 - 65,846,511 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X63,388,983 - 63,410,642 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X65,081,591 - 65,102,344 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX65,081,591 - 65,102,380 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X65,923,644 - 65,944,397 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X83,568,652 - 83,590,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX61,266,251 - 61,287,857 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:15632090   PMID:15960975   PMID:19946888   PMID:22658674   PMID:22681889  


Genomics

Comparative Map Data
Las1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X64,861,472 - 64,883,221 (-)NCBIGRCr8
mRatBN7.2X60,851,969 - 60,873,717 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX60,851,962 - 60,873,687 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX62,324,346 - 62,345,992 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X65,824,867 - 65,846,511 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X63,388,983 - 63,410,642 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X65,081,591 - 65,102,344 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX65,081,591 - 65,102,380 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X65,923,644 - 65,944,397 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X83,568,652 - 83,590,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX61,266,251 - 61,287,857 (-)NCBICelera
Cytogenetic MapXq22NCBI
LAS1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X65,512,582 - 65,534,787 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX65,438,549 - 65,534,810 (-)EnsemblGRCh38hg38GRCh38
GRCh37X64,732,462 - 64,754,667 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X64,649,191 - 64,671,392 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X64,515,488 - 64,537,688NCBI
CeleraX65,079,606 - 65,101,830 (-)NCBICelera
Cytogenetic MapXq12NCBI
HuRefX58,560,622 - 58,582,851 (-)NCBIHuRef
CHM1_1X64,625,528 - 64,647,714 (-)NCBICHM1_1
T2T-CHM13v2.0X63,939,027 - 63,961,232 (-)NCBIT2T-CHM13v2.0
Las1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X94,963,651 - 95,000,580 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX94,978,941 - 95,000,568 (-)EnsemblGRCm39 Ensembl
GRCm38X95,920,045 - 95,956,974 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX95,935,335 - 95,956,962 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X93,130,652 - 93,152,298 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X92,138,032 - 92,159,678 (-)NCBIMGSCv36mm8
CeleraX82,950,134 - 82,971,857 (-)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX42.58NCBI
Las1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554755,164,877 - 5,189,928 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554755,143,641 - 5,189,075 (-)NCBIChiLan1.0ChiLan1.0
LAS1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X65,020,337 - 65,059,103 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X65,023,956 - 65,062,707 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X54,628,539 - 54,650,756 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X64,703,731 - 64,726,304 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX64,703,731 - 64,727,169 (-)Ensemblpanpan1.1panPan2
LAS1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X50,524,199 - 50,543,838 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX50,524,199 - 50,543,777 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX41,363,066 - 41,382,696 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X51,483,023 - 51,502,661 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX51,483,022 - 51,503,346 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X49,453,569 - 49,473,203 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X50,800,422 - 50,820,058 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X50,710,670 - 50,730,300 (-)NCBIUU_Cfam_GSD_1.0
Las1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X51,794,962 - 51,814,713 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366352,560,471 - 2,581,785 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366352,560,586 - 2,580,309 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAS1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX51,741,965 - 51,773,411 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X51,753,600 - 51,773,416 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X58,376,398 - 58,402,562 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LAS1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X55,503,201 - 55,524,995 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX55,503,109 - 55,525,026 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660832,799,218 - 2,820,979 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Las1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248981,723,750 - 1,742,891 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248981,724,406 - 1,743,090 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Las1l
61 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:168
Count of miRNA genes:125
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000016042
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
70221Bp56Blood pressure QTL 564.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X5704214165612192Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 48 33 19 33 1 3 74 30 34 11 1
Low 9 9 8 8 7 8 5 7 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016042   ⟹   ENSRNOP00000016042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX60,851,970 - 60,873,604 (-)Ensembl
Rnor_6.0 EnsemblX65,081,788 - 65,102,344 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000075875   ⟹   ENSRNOP00000067960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX60,872,384 - 60,873,640 (-)Ensembl
Rnor_6.0 EnsemblX65,102,008 - 65,102,380 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX60,851,972 - 60,873,687 (-)Ensembl
Rnor_6.0 EnsemblX65,081,592 - 65,093,939 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076732   ⟹   ENSRNOP00000068191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX60,851,962 - 60,873,687 (-)Ensembl
Rnor_6.0 EnsemblX65,081,764 - 65,101,425 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX65,081,591 - 65,083,911 (-)Ensembl
RefSeq Acc Id: NM_001170590   ⟹   NP_001164061
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X64,861,472 - 64,883,109 (-)NCBI
mRatBN7.2X60,851,969 - 60,873,604 (-)NCBI
Rnor_6.0X65,081,591 - 65,102,344 (-)NCBI
Rnor_5.0X65,923,644 - 65,944,397 (-)NCBI
CeleraX61,266,251 - 61,287,857 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099569   ⟹   XP_038955497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X64,861,472 - 64,883,221 (-)NCBI
mRatBN7.2X60,851,969 - 60,873,717 (-)NCBI
RefSeq Acc Id: XM_039099570   ⟹   XP_038955498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X64,861,472 - 64,883,219 (-)NCBI
mRatBN7.2X60,851,969 - 60,873,715 (-)NCBI
RefSeq Acc Id: XM_039099571   ⟹   XP_038955499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X64,861,472 - 64,883,220 (-)NCBI
mRatBN7.2X60,851,969 - 60,873,716 (-)NCBI
RefSeq Acc Id: XM_039099572   ⟹   XP_038955500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X64,861,708 - 64,883,221 (-)NCBI
mRatBN7.2X60,852,206 - 60,873,717 (-)NCBI
RefSeq Acc Id: XM_063279874   ⟹   XP_063135944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X64,861,472 - 64,883,220 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001164061   ⟸   NM_001170590
- UniProtKB: A0A8I6A8V8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016042   ⟸   ENSRNOT00000016042
RefSeq Acc Id: ENSRNOP00000067960   ⟸   ENSRNOT00000075875
RefSeq Acc Id: ENSRNOP00000068191   ⟸   ENSRNOT00000076732
RefSeq Acc Id: XP_038955497   ⟸   XM_039099569
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A8V8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955499   ⟸   XM_039099571
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A8V8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955498   ⟸   XM_039099570
- Peptide Label: isoform X2
- UniProtKB: A0A096MJM8 (UniProtKB/TrEMBL),   A0A8I6A8V8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955500   ⟸   XM_039099572
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A8V8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135944   ⟸   XM_063279874
- Peptide Label: isoform X5

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FJR8-F1-model_v2 AlphaFold F7FJR8 1-762 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701851
Promoter ID:EPDNEW_R12373
Type:initiation region
Name:Las1l_1
Description:LAS1-like, ribosome biogenesis factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X65,102,391 - 65,102,451EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565755 AgrOrtholog
BioCyc Gene G2FUF-2198 BioCyc
Ensembl Genes ENSRNOG00000021748 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016042.9 UniProtKB/TrEMBL
  ENSRNOT00000075875.2 UniProtKB/TrEMBL
  ENSRNOT00000076543.2 UniProtKB/TrEMBL
  ENSRNOT00000076732.3 UniProtKB/TrEMBL
InterPro Las1 UniProtKB/TrEMBL
NCBI Gene 296865 ENTREZGENE
PANTHER Las1 UniProtKB/TrEMBL
  RIBOSOMAL BIOGENESIS PROTEIN LAS1L UniProtKB/TrEMBL
Pfam Las1 UniProtKB/TrEMBL
PhenoGen Las1l PhenoGen
RatGTEx ENSRNOG00000021748 RatGTEx
UniProt A0A096MJ20_RAT UniProtKB/TrEMBL
  A0A096MJM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A8V8 ENTREZGENE, UniProtKB/TrEMBL
  B5DFD9_RAT UniProtKB/TrEMBL
  F7FJR8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-01 Las1l  LAS1-like, ribosome biogenesis factor  Las1l  LAS1-like (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Las1l  LAS1-like (S. cerevisiae)   Las1l_predicted  LAS1-like (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Las1l_predicted  LAS1-like (S. cerevisiae) (predicted)  RGD1565755_predicted  similar to novel protein (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1565755_predicted  similar to novel protein (predicted)  LOC296865  similar to novel protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC296865  similar to novel protein      Symbol and Name status set to provisional 70820 PROVISIONAL