Eps15l1 (epidermal growth factor receptor pathway substrate 15-like 1) - Rat Genome Database
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Gene: Eps15l1 (epidermal growth factor receptor pathway substrate 15-like 1) Rattus norvegicus
Analyze
Symbol: Eps15l1
Name: epidermal growth factor receptor pathway substrate 15-like 1
RGD ID: 1565708
Description: Predicted to have calcium ion binding activity. Predicted to be involved in endocytosis and endosomal transport. Predicted to localize to clathrin coat of coated pit. Orthologous to human EPS15L1 (epidermal growth factor receptor pathway substrate 15 like 1); INTERACTS WITH cadmium dichloride; 1,2-dichloroethane (ortholog); 1,2-dimethylhydrazine (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: epidermal growth factor receptor substrate 15-like 1; LOC361120; MGC116150; similar to Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15 related sequence) (Eps15-rs)
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01619,127,635 - 19,202,991 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,127,724 - 19,203,003 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01618,470,511 - 18,476,068 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01618,988,795 - 19,064,346 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,846,457 - 17,921,684 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1617,643,994 - 17,719,217 (+)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:18434600   PMID:19946888   PMID:22871113   PMID:25468996  


Genomics

Comparative Map Data
Eps15l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01619,127,635 - 19,202,991 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,127,724 - 19,203,003 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01618,470,511 - 18,476,068 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01618,988,795 - 19,064,346 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,846,457 - 17,921,684 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1617,643,994 - 17,719,217 (+)NCBICelera
Cytogenetic Map16p14NCBI
EPS15L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1916,355,239 - 16,472,085 (-)EnsemblGRCh38hg38GRCh38
GRCh381916,355,244 - 16,472,012 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371916,466,055 - 16,582,823 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361916,333,408 - 16,443,762 (-)NCBINCBI36hg18NCBI36
Build 341916,333,407 - 16,443,762NCBI
Celera1916,374,285 - 16,484,628 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1916,035,081 - 16,151,861 (-)NCBIHuRef
CHM1_11916,465,586 - 16,582,344 (-)NCBICHM1_1
Eps15l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39873,094,834 - 73,175,410 (-)NCBI
GRCm38872,340,990 - 72,421,576 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,340,999 - 72,421,460 (-)EnsemblGRCm38mm10GRCm38
MGSCv37874,864,894 - 74,945,373 (-)NCBIGRCm37mm9NCBIm37
MGSCv36875,269,988 - 75,350,449 (-)NCBImm8
Celera876,678,310 - 76,760,181 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
Eps15l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555241,272,565 - 1,309,294 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555241,264,035 - 1,309,394 (+)NCBIChiLan1.0ChiLan1.0
EPS15L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11916,821,781 - 16,908,541 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1916,821,793 - 16,908,571 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01915,842,964 - 15,959,492 (-)NCBIMhudiblu_PPA_v0panPan3
EPS15L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2046,064,775 - 46,161,535 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12046,064,709 - 46,161,535 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Eps15l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365964,142,951 - 4,241,719 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPS15L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl261,139,045 - 61,243,128 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1261,139,051 - 61,243,127 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2260,771,977 - 60,876,236 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPS15L1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl614,863,089 - 14,978,185 (-)Ensembl
ChlSab1.1614,862,992 - 14,978,218 (-)NCBI
Eps15l1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624908965,948 - 1,014,235 (+)NCBI

Position Markers
D16Cebr3  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01619,183,715 - 19,183,884NCBIRnor6.0
Rnor_5.01619,045,070 - 19,045,239UniSTSRnor5.0
RGSC_v3.41617,902,408 - 17,902,577UniSTSRGSC3.4
Celera1617,699,939 - 17,700,110UniSTS
Cytogenetic Map16p14UniSTS
AI230664  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01618,596,206 - 18,596,394NCBIRnor6.0
Rnor_6.01619,146,124 - 19,146,312NCBIRnor6.0
Rnor_5.01619,007,492 - 19,007,680UniSTSRnor5.0
Rnor_5.01618,469,966 - 18,470,154UniSTSRnor5.0
RGSC_v3.41617,864,812 - 17,865,000UniSTSRGSC3.4
Celera1617,662,358 - 17,662,546UniSTS
Cytogenetic Map16p14UniSTS
RH 3.4 Map16177.6UniSTS
RH142660  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01619,196,181 - 19,196,302NCBIRnor6.0
Rnor_5.01619,057,536 - 19,057,657UniSTSRnor5.0
RGSC_v3.41617,914,874 - 17,914,995UniSTSRGSC3.4
Celera1617,712,407 - 17,712,528UniSTS
Cytogenetic Map16p14UniSTS
RH 3.4 Map16179.8UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16124228366Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16127556253Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16127556253Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16127556253Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16131816439Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16133160624Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16134465490Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16141240937Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16141240937Rat
631561Hcuc2Hepatic copper content QTL 22.8hepatic copper amount (VT:0003065)liver total copper weight (CMO:0001507)16141240957Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)1624459345244593Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)16109005486162972Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16134074146340741Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)16155018749247447Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)16155018763210301Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16155018763210301Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)16155018763210301Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)16155018763210301Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16172829746728297Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16413635523105837Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16413635545905331Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16501380245905331Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16501380245905331Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16501380245905331Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16501380250013802Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16501380250169318Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16501380252144919Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16501380264012784Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16509870419398181Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161730939622744540Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:211
Count of miRNA genes:148
Interacting mature miRNAs:165
Transcripts:ENSRNOT00000018960
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 38 22 19 22 1 4 74 35 39 11 1
Low 7 19 19 19 7 7 2 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001029921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001841541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAHX01086786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01086787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC094598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000018960   ⟹   ENSRNOP00000018960
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1619,127,724 - 19,203,003 (+)Ensembl
RefSeq Acc Id: NM_001029921   ⟹   NP_001025092
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,127,775 - 19,202,991 (+)NCBI
Rnor_5.01618,988,795 - 19,064,346 (+)NCBI
RGSC_v3.41617,846,457 - 17,921,684 (+)RGD
Celera1617,643,994 - 17,719,217 (+)RGD
Sequence:
RefSeq Acc Id: XM_006252802   ⟹   XP_006252864
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,127,635 - 19,202,991 (+)NCBI
Rnor_5.01618,988,795 - 19,064,346 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006252804   ⟹   XP_006252866
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,127,637 - 19,202,991 (+)NCBI
Rnor_5.01618,988,795 - 19,064,346 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008771122   ⟹   XP_008769344
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,127,644 - 19,202,991 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600166   ⟹   XP_017455655
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,127,636 - 19,202,991 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600167   ⟹   XP_017455656
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,127,635 - 19,202,991 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600168   ⟹   XP_017455657
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,127,642 - 19,202,991 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600169   ⟹   XP_017455658
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,127,642 - 19,202,991 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600170   ⟹   XP_017455659
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,127,643 - 19,182,346 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600171   ⟹   XP_017455660
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,127,642 - 19,181,069 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600172   ⟹   XP_017455661
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,127,642 - 19,182,346 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600173   ⟹   XP_017455662
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,127,644 - 19,181,068 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600174   ⟹   XP_017455663
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,127,645 - 19,182,116 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001841541
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,127,645 - 19,202,501 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001025092   ⟸   NM_001029921
- UniProtKB: A0A0G2QC53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252864   ⟸   XM_006252802
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006252866   ⟸   XM_006252804
- Peptide Label: isoform X3
- UniProtKB: D3ZJR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769344   ⟸   XM_008771122
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_017455656   ⟸   XM_017600167
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017455655   ⟸   XM_017600166
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017455657   ⟸   XM_017600168
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017455658   ⟸   XM_017600169
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017455661   ⟸   XM_017600172
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_017455660   ⟸   XM_017600171
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_017455659   ⟸   XM_017600170
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_017455662   ⟸   XM_017600173
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_017455663   ⟸   XM_017600174
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: ENSRNOP00000018960   ⟸   ENSRNOT00000018960
Protein Domains
EF-hand   EH

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699984
Promoter ID:EPDNEW_R10507
Type:multiple initiation site
Name:Eps15l1_1
Description:epidermal growth factor receptor pathway substrate 15-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,127,753 - 19,127,813EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565708 AgrOrtholog
Ensembl Genes ENSRNOG00000013502 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000018960 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018960 ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7453598 IMAGE-MGC_LOAD
InterPro EF-hand-like_dom UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_Ca-bd UniProtKB/TrEMBL
  EPS15_homology UniProtKB/TrEMBL
  Ubiquitin-int_motif UniProtKB/TrEMBL
KEGG Report rno:361120 UniProtKB/TrEMBL
MGC_CLONE MGC:116150 IMAGE-MGC_LOAD
NCBI Gene 361120 ENTREZGENE
Pfam EF-hand_4 UniProtKB/TrEMBL
PhenoGen Eps15l1 PhenoGen
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  PS50031 UniProtKB/TrEMBL
  UIM UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
  SM00027 UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniGene Rn.20801 ENTREZGENE
UniProt A0A0G2QC53 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJR1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q4QQT7 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Eps15l1  epidermal growth factor receptor pathway substrate 15-like 1  LOC361120  similar to Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15 related sequence) (Eps15-rs)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC361120  similar to Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15 related sequence) (Eps15-rs)      Symbol and Name status set to provisional 70820 PROVISIONAL