Galns (galactosamine (N-acetyl)-6-sulfatase) - Rat Genome Database

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Gene: Galns (galactosamine (N-acetyl)-6-sulfatase) Rattus norvegicus
Analyze
Symbol: Galns
Name: galactosamine (N-acetyl)-6-sulfatase
RGD ID: 1565391
Description: Predicted to enable N-acetylgalactosamine-6-sulfatase activity and arylsulfatase activity. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in mucopolysaccharidosis IVA. Orthologous to human GALNS (galactosamine (N-acetyl)-6-sulfatase); PARTICIPATES IN glycosaminoglycan degradation pathway; INTERACTS WITH 4,4'-sulfonyldiphenol; bisphenol A; bisphenol F.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chondroitinase; chondroitinsulfatase; galactosamine (N-acetyl)-6-sulfate sulfatase; galactose-6-sulfate sulfatase; galNAc6S sulfatase; N-acetylgalactosamine-6-sulfatase; N-acetylgalactosamine-6-sulfate sulfatase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81967,537,175 - 67,570,900 (-)NCBIGRCr8
mRatBN7.21950,628,639 - 50,662,477 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1950,628,552 - 50,662,246 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1957,425,872 - 57,456,984 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01958,105,983 - 58,137,126 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,324,497 - 60,355,602 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01955,391,004 - 55,423,328 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,389,462 - 55,423,150 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01966,099,752 - 66,131,872 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,859,282 - 52,890,422 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1949,870,467 - 49,901,606 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
lysosome  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. Sardiello M, etal., Hum Mol Genet. 2005 Nov 1;14(21):3203-17. Epub 2005 Sep 20.
Additional References at PubMed
PMID:15057822   PMID:15962010   PMID:23376485   PMID:23533145   PMID:34504088  


Genomics

Comparative Map Data
Galns
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81967,537,175 - 67,570,900 (-)NCBIGRCr8
mRatBN7.21950,628,639 - 50,662,477 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1950,628,552 - 50,662,246 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1957,425,872 - 57,456,984 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01958,105,983 - 58,137,126 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,324,497 - 60,355,602 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01955,391,004 - 55,423,328 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,389,462 - 55,423,150 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01966,099,752 - 66,131,872 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,859,282 - 52,890,422 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1949,870,467 - 49,901,606 (-)NCBICelera
Cytogenetic Map19q12NCBI
GALNS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381688,813,734 - 88,856,947 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1688,813,734 - 88,856,970 (-)EnsemblGRCh38hg38GRCh38
GRCh371688,880,142 - 88,923,355 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361687,407,643 - 87,450,885 (-)NCBINCBI36Build 36hg18NCBI36
Build 341687,407,643 - 87,450,841NCBI
Celera1673,948,779 - 73,991,965 (-)NCBICelera
Cytogenetic Map16q24.3NCBI
HuRef1674,577,353 - 74,620,495 (-)NCBIHuRef
CHM1_11690,291,409 - 90,334,642 (-)NCBICHM1_1
T2T-CHM13v2.01694,884,254 - 94,927,341 (-)NCBIT2T-CHM13v2.0
Galns
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398123,304,976 - 123,338,226 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8123,304,981 - 123,338,202 (-)EnsemblGRCm39 Ensembl
GRCm388122,578,237 - 122,611,701 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8122,578,242 - 122,611,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv378125,102,137 - 125,135,241 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368125,464,331 - 125,497,431 (-)NCBIMGSCv36mm8
Celera8126,807,841 - 126,840,944 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map871.91NCBI
Galns
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555412,691,103 - 2,710,696 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555412,691,103 - 2,711,137 (-)NCBIChiLan1.0ChiLan1.0
GALNS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21898,586,735 - 98,632,432 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116104,498,933 - 104,544,833 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01669,557,956 - 69,571,421 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11689,183,282 - 89,213,300 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1689,183,950 - 89,217,036 (-)Ensemblpanpan1.1panPan2
GALNS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1564,534,194 - 64,562,169 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl564,534,131 - 64,562,169 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha564,545,663 - 64,573,635 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0564,754,387 - 64,782,393 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl564,754,308 - 64,783,045 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1564,780,491 - 64,808,572 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0564,612,123 - 64,640,078 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0565,018,205 - 65,046,122 (+)NCBIUU_Cfam_GSD_1.0
Galns
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934925,138,474 - 25,159,591 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936641894,869 - 912,533 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936641893,976 - 913,138 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GALNS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6869,244 - 890,134 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16869,284 - 890,137 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.261,093,151 - 1,098,277 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103233460
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1574,201,468 - 74,243,478 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660471,433,201 - 1,477,507 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Galns
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624746786,422 - 805,073 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624746786,259 - 805,450 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Galns
200 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:65
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000019528
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat

Markers in Region
BE109337  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21950,632,255 - 50,632,405 (+)MAPPERmRatBN7.2
Rnor_6.01955,393,107 - 55,393,256NCBIRnor6.0
Rnor_5.01966,101,623 - 66,101,772UniSTSRnor5.0
RGSC_v3.41952,860,476 - 52,860,625UniSTSRGSC3.4
Celera1949,871,661 - 49,871,810UniSTS
RH 3.4 Map19701.81UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 9 8 3
Low 2 43 57 41 10 41 8 11 74 35 33 8 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000019528   ⟹   ENSRNOP00000019528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1950,628,552 - 50,662,246 (-)Ensembl
Rnor_6.0 Ensembl1955,391,913 - 55,423,052 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079641   ⟹   ENSRNOP00000073046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1950,628,552 - 50,662,246 (-)Ensembl
Rnor_6.0 Ensembl1955,389,462 - 55,423,150 (-)Ensembl
RefSeq Acc Id: NM_001047851   ⟹   NP_001041316
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81967,537,175 - 67,570,829 (-)NCBI
mRatBN7.21950,628,639 - 50,662,299 (-)NCBI
Rnor_6.01955,391,913 - 55,423,052 (-)NCBI
Rnor_5.01966,099,752 - 66,131,872 (-)NCBI
RGSC_v3.41952,859,282 - 52,890,422 (-)RGD
Celera1949,870,467 - 49,901,606 (-)RGD
Sequence:
RefSeq Acc Id: XM_017601245   ⟹   XP_017456734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81967,537,192 - 67,570,894 (-)NCBI
mRatBN7.21950,628,639 - 50,662,477 (-)NCBI
Rnor_6.01955,391,004 - 55,423,328 (-)NCBI
Sequence:
RefSeq Acc Id: XR_010059982
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81967,541,345 - 67,570,900 (-)NCBI
RefSeq Acc Id: NP_001041316   ⟸   NM_001047851
- Peptide Label: precursor
- UniProtKB: Q32KJ6 (UniProtKB/Swiss-Prot),   A6IZT2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456734   ⟸   XM_017601245
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000073046   ⟸   ENSRNOT00000079641
RefSeq Acc Id: ENSRNOP00000019528   ⟸   ENSRNOT00000019528
Protein Domains
Sulfatase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q32KJ6-F1-model_v2 AlphaFold Q32KJ6 1-524 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701213
Promoter ID:EPDNEW_R11736
Type:initiation region
Name:Galns_1
Description:galactosamine (N-acetyl)-6-sulfatase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01955,423,090 - 55,423,150EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565391 AgrOrtholog
BioCyc Gene G2FUF-5380 BioCyc
Ensembl Genes ENSRNOG00000014461 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055020552 UniProtKB/Swiss-Prot
  ENSRNOG00060016854 UniProtKB/Swiss-Prot
  ENSRNOG00065018257 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019528 ENTREZGENE
  ENSRNOT00000019528.5 UniProtKB/Swiss-Prot
  ENSRNOT00000079641.2 UniProtKB/TrEMBL
  ENSRNOT00055035087 UniProtKB/Swiss-Prot
  ENSRNOT00060028827 UniProtKB/Swiss-Prot
  ENSRNOT00065030604 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.720.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Alkaline_phosphatase_core_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GALNS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sulfatase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sulfatase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:292073 UniProtKB/Swiss-Prot
NCBI Gene 292073 ENTREZGENE
PANTHER ARYLSULFATASE FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARYLSULFATASE G-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sulfatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sulfatase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Galns PhenoGen
PROSITE SULFATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014461 RatGTEx
  ENSRNOG00055020552 RatGTEx
  ENSRNOG00060016854 RatGTEx
  ENSRNOG00065018257 RatGTEx
Superfamily-SCOP SSF53649 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K4H6_RAT UniProtKB/TrEMBL
  A6IZT2 ENTREZGENE, UniProtKB/TrEMBL
  GALNS_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-09 Galns  galactosamine (N-acetyl)-6-sulfatase  Galns  galactosamine (N-acetyl)-6-sulfate sulfatase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 Galns  galactosamine (N-acetyl)-6-sulfate sulfatase      Symbol and Name status set to provisional 70820 PROVISIONAL