Ppp1r21 (protein phosphatase 1, regulatory subunit 21) - Rat Genome Database

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Gene: Ppp1r21 (protein phosphatase 1, regulatory subunit 21) Rattus norvegicus
Analyze
Symbol: Ppp1r21
Name: protein phosphatase 1, regulatory subunit 21
RGD ID: 1565310
Description: Predicted to be active in early endosome. Orthologous to human PPP1R21 (protein phosphatase 1 regulatory subunit 21); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; buspirone.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC362697; RGD1565310; similar to RIKEN cDNA 1110018J12; uncharacterized protein LOC362697
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8611,655,059 - 11,724,219 (-)NCBIGRCr8
mRatBN7.265,901,518 - 5,970,684 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl65,901,518 - 5,970,684 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx66,184,768 - 6,254,008 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.066,494,144 - 6,563,384 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.066,021,317 - 6,090,561 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0612,253,788 - 12,323,427 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl612,253,788 - 12,323,421 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0622,270,224 - 22,286,405 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0622,219,113 - 22,263,931 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4612,360,976 - 12,405,728 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera65,674,130 - 5,741,099 (-)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
early endosome  (IBA,ISO)
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14643017   PMID:19389623   PMID:19946888   PMID:30520571  


Genomics

Comparative Map Data
Ppp1r21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8611,655,059 - 11,724,219 (-)NCBIGRCr8
mRatBN7.265,901,518 - 5,970,684 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl65,901,518 - 5,970,684 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx66,184,768 - 6,254,008 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.066,494,144 - 6,563,384 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.066,021,317 - 6,090,561 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0612,253,788 - 12,323,427 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl612,253,788 - 12,323,421 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0622,270,224 - 22,286,405 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0622,219,113 - 22,263,931 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4612,360,976 - 12,405,728 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera65,674,130 - 5,741,099 (-)NCBICelera
Cytogenetic Map6q12NCBI
PPP1R21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38248,440,766 - 48,515,386 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl248,440,598 - 48,515,391 (+)EnsemblGRCh38hg38GRCh38
GRCh37248,667,905 - 48,742,525 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36248,521,412 - 48,596,029 (+)NCBINCBI36Build 36hg18NCBI36
Celera248,507,697 - 48,582,287 (+)NCBICelera
Cytogenetic Map2p16.3NCBI
HuRef248,403,647 - 48,478,111 (+)NCBIHuRef
CHM1_1248,598,083 - 48,672,622 (+)NCBICHM1_1
T2T-CHM13v2.0248,446,714 - 48,521,263 (+)NCBIT2T-CHM13v2.0
Ppp1r21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391788,837,552 - 88,895,795 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1788,837,546 - 88,895,795 (+)EnsemblGRCm39 Ensembl
GRCm381788,530,124 - 88,588,367 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1788,530,118 - 88,588,367 (+)EnsemblGRCm38mm10GRCm38
MGSCv371788,929,464 - 88,987,707 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361788,438,587 - 88,496,691 (+)NCBIMGSCv36mm8
Celera1792,948,195 - 93,006,786 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1758.02NCBI
Ppp1r21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544115,004,888 - 15,061,967 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544115,002,126 - 15,061,967 (+)NCBIChiLan1.0ChiLan1.0
PPP1R21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21277,862,209 - 77,936,543 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A77,866,179 - 77,940,513 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A48,568,114 - 48,642,401 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A49,489,967 - 49,563,464 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A49,489,967 - 49,563,464 (+)Ensemblpanpan1.1panPan2
PPP1R21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11050,350,521 - 50,415,803 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1050,350,545 - 50,415,732 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1050,204,226 - 50,269,500 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01051,229,673 - 51,295,006 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1051,229,729 - 51,295,065 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11050,929,749 - 50,995,045 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01051,216,609 - 51,281,750 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01051,405,081 - 51,470,229 (+)NCBIUU_Cfam_GSD_1.0
Ppp1r21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629232,698,552 - 32,765,112 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365084,125,444 - 4,193,323 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365084,127,373 - 4,193,206 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl392,156,008 - 92,227,708 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1392,156,002 - 92,227,719 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2397,965,691 - 98,036,009 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11458,649,556 - 58,723,610 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1458,648,748 - 58,723,553 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604553,125,831 - 53,196,517 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473829,662,864 - 29,737,676 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473829,662,619 - 29,785,679 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp1r21
224 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:152
Count of miRNA genes:110
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000061675, ENSRNOT00000061677
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6507449719988050Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 14 33 24 19 24 74 35 38 11
Low 29 24 17 17 8 11 3 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000061675   ⟹   ENSRNOP00000058387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl65,901,518 - 5,970,684 (-)Ensembl
Rnor_6.0 Ensembl612,253,788 - 12,323,421 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095727   ⟹   ENSRNOP00000097053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl65,906,456 - 5,958,211 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108074   ⟹   ENSRNOP00000078160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl65,901,523 - 5,970,684 (-)Ensembl
RefSeq Acc Id: NM_001271305   ⟹   NP_001258234
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8611,655,059 - 11,724,219 (-)NCBI
mRatBN7.265,901,518 - 5,970,684 (-)NCBI
Rnor_6.0612,253,788 - 12,323,421 (+)NCBI
Rnor_5.0622,219,113 - 22,263,931 (+)NCBI
Rnor_5.0622,270,224 - 22,286,405 (+)NCBI
Celera65,674,130 - 5,741,099 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764482   ⟹   XP_008762704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8611,655,059 - 11,724,091 (-)NCBI
mRatBN7.265,901,518 - 5,970,569 (-)NCBI
Rnor_6.0612,266,829 - 12,323,427 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258234 (Get FASTA)   NCBI Sequence Viewer  
  XP_008762704 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM02625 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058387
  ENSRNOP00000058387.4
  ENSRNOP00000078160.1
  ENSRNOP00000097053.1
RefSeq Acc Id: NP_001258234   ⟸   NM_001271305
- UniProtKB: F1LYZ8 (UniProtKB/TrEMBL),   A6H9C0 (UniProtKB/TrEMBL),   A0A8I6B588 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762704   ⟸   XM_008764482
- Peptide Label: isoform X1
- UniProtKB: A0A8I6B588 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000058387   ⟸   ENSRNOT00000061675
RefSeq Acc Id: ENSRNOP00000078160   ⟸   ENSRNOT00000108074
RefSeq Acc Id: ENSRNOP00000097053   ⟸   ENSRNOT00000095727
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LYZ8-F1-model_v2 AlphaFold F1LYZ8 1-780 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694400
Promoter ID:EPDNEW_R4924
Type:initiation region
Name:Ppp1r21_1
Description:protein phosphatase 1, regulatory subunit 21
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0612,253,786 - 12,253,846EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565310 AgrOrtholog
BioCyc Gene G2FUF-38771 BioCyc
Ensembl Genes ENSRNOG00000016528 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061675 ENTREZGENE
  ENSRNOT00000061675.6 UniProtKB/TrEMBL
  ENSRNOT00000095727.1 UniProtKB/TrEMBL
  ENSRNOT00000108074.1 UniProtKB/TrEMBL
InterPro KLRAQ/TTKRSYEDQ_C UniProtKB/TrEMBL
  PPP1R21 UniProtKB/TrEMBL
  PPP1R21_C UniProtKB/TrEMBL
  Unchr_KLRAQ/TTKRSYEDQ_N UniProtKB/TrEMBL
KEGG Report rno:362697 UniProtKB/TrEMBL
NCBI Gene 362697 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 21 UniProtKB/TrEMBL
  PTHR21448 UniProtKB/TrEMBL
Pfam KLRAQ UniProtKB/TrEMBL
  PPP1R21_C UniProtKB/TrEMBL
  TTKRSYEDQ UniProtKB/TrEMBL
PhenoGen Ppp1r21 PhenoGen
RatGTEx ENSRNOG00000016528 RatGTEx
SMART KLRAQ UniProtKB/TrEMBL
UniProt A0A8I5Y721_RAT UniProtKB/TrEMBL
  A0A8I6B588 ENTREZGENE, UniProtKB/TrEMBL
  A6H9C0 ENTREZGENE, UniProtKB/TrEMBL
  F1LYZ8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-07 Ppp1r21  protein phosphatase 1, regulatory subunit 21  RGD1565310  similar to RIKEN cDNA 1110018J12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565310  similar to RIKEN cDNA 1110018J12   RGD1565310_predicted  similar to RIKEN cDNA 1110018J12 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565310_predicted  similar to RIKEN cDNA 1110018J12 (predicted)  LOC362697  similar to RIKEN cDNA 1110018J12  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC362697  similar to RIKEN cDNA 1110018J12      Symbol and Name status set to provisional 70820 PROVISIONAL