Awat2 (acyl-CoA wax alcohol acyltransferase 2) - Rat Genome Database

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Gene: Awat2 (acyl-CoA wax alcohol acyltransferase 2) Rattus norvegicus
Analyze
Symbol: Awat2
Name: acyl-CoA wax alcohol acyltransferase 2
RGD ID: 1565111
Description: Predicted to enable long-chain-alcohol O-fatty-acyltransferase activity and retinol O-fatty-acyltransferase activity. Predicted to be involved in monoacylglycerol biosynthetic process. Predicted to act upstream of or within wax biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human AWAT2 (acyl-CoA wax alcohol acyltransferase 2); PARTICIPATES IN retinol metabolic pathway; INTERACTS WITH acrylamide; 17beta-estradiol (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Dgat2l4; diacylglycerol O-acyltransferase 2-like 4; LOC302425; RGD1565111; similar to wax synthase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X69,521,778 - 69,530,664 (-)NCBIGRCr8
mRatBN7.2X65,481,676 - 65,490,562 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX65,481,929 - 65,527,625 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX66,965,672 - 66,973,932 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X70,466,062 - 70,474,322 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,026,954 - 68,035,214 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X70,224,761 - 70,233,021 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX70,224,654 - 70,270,693 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X71,097,874 - 71,106,134 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X88,395,929 - 88,404,189 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX65,843,059 - 65,851,319 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15220349   PMID:15671038   PMID:16106050   PMID:24799687   PMID:28096191   PMID:28420705  


Genomics

Comparative Map Data
Awat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X69,521,778 - 69,530,664 (-)NCBIGRCr8
mRatBN7.2X65,481,676 - 65,490,562 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX65,481,929 - 65,527,625 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX66,965,672 - 66,973,932 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X70,466,062 - 70,474,322 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,026,954 - 68,035,214 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X70,224,761 - 70,233,021 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX70,224,654 - 70,270,693 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X71,097,874 - 71,106,134 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X88,395,929 - 88,404,189 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX65,843,059 - 65,851,319 (-)NCBICelera
Cytogenetic MapXq22NCBI
AWAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X70,040,542 - 70,049,938 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX70,040,542 - 70,049,938 (-)EnsemblGRCh38hg38GRCh38
GRCh37X69,260,392 - 69,269,788 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X69,177,117 - 69,186,513 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX69,613,775 - 69,623,166 (-)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX63,081,194 - 63,090,585 (-)NCBIHuRef
CHM1_1X69,154,000 - 69,163,391 (-)NCBICHM1_1
T2T-CHM13v2.0X68,473,894 - 68,483,288 (-)NCBIT2T-CHM13v2.0
Awat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X99,445,827 - 99,537,885 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX99,445,827 - 99,486,323 (-)EnsemblGRCm39 Ensembl
GRCm38X100,402,221 - 100,494,278 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX100,402,221 - 100,442,717 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X97,597,560 - 97,607,901 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X96,604,940 - 96,615,281 (-)NCBIMGSCv36mm8
CeleraX87,327,787 - 87,338,155 (-)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX43.71NCBI
Awat2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554759,592,984 - 9,634,811 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554759,594,157 - 9,634,596 (-)NCBIChiLan1.0ChiLan1.0
AWAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X69,717,450 - 69,727,806 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X69,722,000 - 69,731,409 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X59,308,600 - 59,318,940 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X69,372,246 - 69,381,644 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX69,372,246 - 69,381,644 (-)Ensemblpanpan1.1panPan2
AWAT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X54,516,465 - 54,531,450 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX54,516,776 - 54,531,450 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX45,342,795 - 45,357,915 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X55,483,082 - 55,498,202 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX55,483,069 - 55,498,100 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X53,452,127 - 53,467,243 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X54,782,920 - 54,798,043 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X54,710,080 - 54,725,204 (-)NCBIUU_Cfam_GSD_1.0
Awat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X47,660,270 - 47,671,248 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367771,563,229 - 1,573,993 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367771,562,900 - 1,574,018 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AWAT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX56,104,509 - 56,114,744 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X56,101,635 - 56,108,243 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X63,301,798 - 63,311,924 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AWAT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X59,863,353 - 59,872,621 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX59,863,866 - 59,871,925 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660651,731,627 - 1,740,942 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Awat2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462489141,890 - 52,628 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462489149,479 - 53,290 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Awat2
27 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:49
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000004048
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
70221Bp56Blood pressure QTL 564.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X5704214165612192Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 2 2 2 14 2
Below cutoff 1 10 15 3 9 3 6 6 10 7 16 10 6

Sequence


RefSeq Acc Id: ENSRNOT00000004048   ⟹   ENSRNOP00000004048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX65,481,929 - 65,490,584 (-)Ensembl
Rnor_6.0 EnsemblX70,224,654 - 70,233,073 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX65,481,929 - 65,527,625 (-)Ensembl
Rnor_6.0 EnsemblX70,226,474 - 70,270,693 (-)Ensembl
RefSeq Acc Id: NM_001191724   ⟹   NP_001178653
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,521,778 - 69,530,664 (-)NCBI
mRatBN7.2X65,481,676 - 65,490,562 (-)NCBI
Rnor_6.0X70,224,761 - 70,233,021 (-)NCBI
Rnor_5.0X71,097,874 - 71,106,134 (-)NCBI
CeleraX65,843,059 - 65,851,319 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178653 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95940 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004048
  ENSRNOP00000004048.5
  ENSRNOP00000090922.1
RefSeq Acc Id: NP_001178653   ⟸   NM_001191724
- UniProtKB: D4A598 (UniProtKB/TrEMBL),   A6IQ73 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004048   ⟸   ENSRNOT00000004048

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A598-F1-model_v2 AlphaFold D4A598 1-333 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701863
Promoter ID:EPDNEW_R12387
Type:single initiation site
Name:Awat2_1
Description:acyl-CoA wax alcohol acyltransferase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X70,233,083 - 70,233,143EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565111 AgrOrtholog
BioCyc Gene G2FUF-2136 BioCyc
Ensembl Genes ENSRNOG00000003030 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004048 ENTREZGENE
  ENSRNOT00000004048.7 UniProtKB/TrEMBL
  ENSRNOT00000076097.2 UniProtKB/TrEMBL
InterPro DAGAT UniProtKB/TrEMBL
KEGG Report rno:302425 UniProtKB/TrEMBL
NCBI Gene 302425 ENTREZGENE
PANTHER ACYL-COA WAX ALCOHOL ACYLTRANSFERASE 2-RELATED UniProtKB/TrEMBL
  DIACYLGLYCEROL O-ACYLTRANSFERASE UniProtKB/TrEMBL
Pfam DAGAT UniProtKB/TrEMBL
PhenoGen Awat2 PhenoGen
RatGTEx ENSRNOG00000003030 RatGTEx
UniProt A0A8I6AEQ3_RAT UniProtKB/TrEMBL
  A6IQ73 ENTREZGENE, UniProtKB/TrEMBL
  D4A598 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-03-24 Awat2  acyl-CoA wax alcohol acyltransferase 2  Dgat2l4  diacylglycerol O-acyltransferase 2-like 4   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Dgat2l4  diacylglycerol O-acyltransferase 2-like 4   Dgat2l4_predicted  diacylglycerol O-acyltransferase 2-like 4 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Dgat2l4_predicted  diacylglycerol O-acyltransferase 2-like 4 (predicted)  RGD1565111_predicted  similar to wax synthase (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1565111_predicted  similar to wax synthase (predicted)  LOC302425  similar to wax synthase  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302425  similar to wax synthase      Symbol and Name status set to provisional 70820 PROVISIONAL