![]()
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Shld2 | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:1354134 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SHLD2 mRNA | CTD | PMID:22079256 | Shld2 | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | RGD:1320663 | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SHLD2 mRNA | CTD | PMID:36331819 | Shld2 | Rat | 1,2-dichloroethane | decreases expression | ISO | RGD:1320663 | 6480464 | ethylene dichloride results in decreased expression of FAM35A mRNA; ethylene dichloride results in decreased expression more ... | CTD | PMID:28189721|PMID:28960355 | Shld2 | Rat | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of FAM35A mRNA | CTD | PMID:32145629 | Shld2 | Rat | 17beta-estradiol | decreases expression | ISO | RGD:1320663 | 6480464 | Estradiol results in decreased expression of SHLD2 mRNA | CTD | PMID:39298647 | Shld2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1320663 | 6480464 | [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of SHLD2 mRNA | CTD | PMID:16214954 | Shld2 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:1354134 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | Shld2 | Rat | 4,4'-sulfonyldiphenol | affects expression | ISO | RGD:1320663 | 6480464 | bisphenol S affects the expression of SHLD2 mRNA | CTD | PMID:39298647 | Shld2 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of FAM35A mRNA | CTD | PMID:30047161 | Shld2 | Rat | aflatoxin B1 | decreases methylation | ISO | RGD:1354134 | 6480464 | Aflatoxin B1 results in decreased methylation of SHLD2 gene | CTD | PMID:27153756 | Shld2 | Rat | aflatoxin M1 | decreases expression | ISO | RGD:1354134 | 6480464 | Aflatoxin M1 results in decreased expression of SHLD2 mRNA | CTD | PMID:30928695 | Shld2 | Rat | all-trans-retinoic acid | decreases expression | ISO | RGD:1354134 | 6480464 | Tretinoin results in decreased expression of FAM35A mRNA | CTD | PMID:33167477 | Shld2 | Rat | amiodarone | decreases expression | ISO | RGD:1320663 | 6480464 | Amiodarone results in decreased expression of SHLD2 mRNA | CTD | PMID:24535564 | Shld2 | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of FAM35A mRNA | CTD | PMID:30047161 | Shld2 | Rat | aristolochic acid A | decreases expression | ISO | RGD:1354134 | 6480464 | aristolochic acid I results in decreased expression of SHLD2 mRNA | CTD | PMID:33212167 | Shld2 | Rat | arsane | multiple interactions | ISO | RGD:1354134 | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Shld2 | Rat | arsenic atom | multiple interactions | ISO | RGD:1354134 | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Shld2 | Rat | benzo[a]pyrene | decreases expression | ISO | RGD:1354134 | 6480464 | Benzo(a)pyrene results in decreased expression of SHLD2 mRNA | CTD | PMID:32234424 | Shld2 | Rat | benzo[a]pyrene diol epoxide I | affects expression | ISO | RGD:1354134 | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SHLD2 mRNA | CTD | PMID:20382639 | Shld2 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | RGD:1354134 | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SHLD2 mRNA | CTD | PMID:19150397 | Shld2 | Rat | Benzo[ghi]perylene | decreases expression | ISO | RGD:1320663 | 6480464 | 1,12-benzoperylene results in decreased expression of SHLD2 mRNA | CTD | PMID:26377693 | Shld2 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of SHLD2 mRNA | CTD | PMID:25181051 | Shld2 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of FAM35A mRNA | CTD | PMID:32145629 | Shld2 | Rat | bisphenol F | multiple interactions | ISO | RGD:1354134 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | Shld2 | Rat | cadmium dichloride | decreases expression | ISO | RGD:1354134 | 6480464 | Cadmium Chloride results in decreased expression of SHLD2 mRNA | CTD | PMID:38568856 | Shld2 | Rat | carbon nanotube | increases expression | ISO | RGD:1320663 | 6480464 | Nanotubes, Carbon results in increased expression of SHLD2 mRNA | CTD | PMID:25620056 | Shld2 | Rat | carbon nanotube | decreases expression | ISO | RGD:1320663 | 6480464 | Nanotubes, Carbon analog results in decreased expression of SHLD2 mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25554681|PMID:25620056 | Shld2 | Rat | copper(II) sulfate | decreases expression | ISO | RGD:1354134 | 6480464 | Copper Sulfate results in decreased expression of SHLD2 mRNA | CTD | PMID:19549813 | Shld2 | Rat | crocidolite asbestos | decreases expression | ISO | RGD:1320663 | 6480464 | Asbestos, Crocidolite results in decreased expression of SHLD2 mRNA | CTD | PMID:29279043 | Shld2 | Rat | dexamethasone | multiple interactions | ISO | RGD:1354134 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | Shld2 | Rat | dibutyl phthalate | decreases expression | ISO | RGD:1320663 | 6480464 | Dibutyl Phthalate results in decreased expression of SHLD2 mRNA | CTD | PMID:21266533 | Shld2 | Rat | dicrotophos | decreases expression | ISO | RGD:1354134 | 6480464 | dicrotophos results in decreased expression of SHLD2 mRNA | CTD | PMID:28302478 | Shld2 | Rat | dieldrin | decreases expression | EXP | | 6480464 | Dieldrin results in decreased expression of SHLD2 mRNA | CTD | PMID:23153324 | Shld2 | Rat | diuron | decreases expression | ISO | RGD:1354134 | 6480464 | Diuron results in decreased expression of SHLD2 mRNA | CTD | PMID:35967413 | Shld2 | Rat | doxorubicin | decreases expression | ISO | RGD:1354134 | 6480464 | Doxorubicin results in decreased expression of SHLD2 mRNA | CTD | PMID:29803840 | Shld2 | Rat | folic acid | decreases expression | ISO | RGD:1320663 | 6480464 | Folic Acid results in decreased expression of FAM35A mRNA | CTD | PMID:25629700 | Shld2 | Rat | formaldehyde | decreases expression | ISO | RGD:1354134 | 6480464 | Formaldehyde results in decreased expression of SHLD2 mRNA | CTD | PMID:20655997 | Shld2 | Rat | furan | increases expression | ISO | RGD:1320663 | 6480464 | furan results in increased expression of SHLD2 mRNA | CTD | PMID:24183702 | Shld2 | Rat | indometacin | multiple interactions | ISO | RGD:1354134 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | Shld2 | Rat | inulin | multiple interactions | ISO | RGD:1320663 | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of SHLD2 mRNA | CTD | PMID:36331819 | Shld2 | Rat | manganese atom | multiple interactions | ISO | RGD:1354134 | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Shld2 | Rat | manganese(0) | multiple interactions | ISO | RGD:1354134 | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Shld2 | Rat | manganese(II) chloride | multiple interactions | ISO | RGD:1354134 | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Shld2 | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of FAM35A mRNA | CTD | PMID:30047161 | Shld2 | Rat | paracetamol | decreases expression | ISO | RGD:1354134 | 6480464 | Acetaminophen results in decreased expression of SHLD2 mRNA | CTD | PMID:22230336 | Shld2 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | RGD:1320663 | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SHLD2 mRNA; [perfluorooctane sulfonic more ... | CTD | PMID:36331819 | Shld2 | Rat | pirinixic acid | decreases expression | ISO | RGD:1320663 | 6480464 | pirinixic acid results in decreased expression of SHLD2 mRNA | CTD | PMID:20813756|PMID:23811191 | Shld2 | Rat | potassium chromate | decreases expression | ISO | RGD:1354134 | 6480464 | potassium chromate(VI) results in decreased expression of SHLD2 mRNA | CTD | PMID:22079256 | Shld2 | Rat | potassium chromate | multiple interactions | ISO | RGD:1354134 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SHLD2 mRNA | CTD | PMID:22079256 | Shld2 | Rat | pregnenolone 16alpha-carbonitrile | increases expression | ISO | RGD:1320663 | 6480464 | Pregnenolone Carbonitrile results in increased expression of SHLD2 mRNA | CTD | PMID:28903501 | Shld2 | Rat | sodium arsenite | decreases expression | ISO | RGD:1354134 | 6480464 | sodium arsenite results in decreased expression of SHLD2 mRNA | CTD | PMID:38568856 | Shld2 | Rat | sodium arsenite | multiple interactions | ISO | RGD:1354134 | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Shld2 | Rat | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of FAM35A mRNA | CTD | PMID:30047161 | Shld2 | Rat | testosterone | decreases expression | ISO | RGD:1354134 | 6480464 | Testosterone results in decreased expression of FAM35A mRNA | CTD | PMID:33359661 | Shld2 | Rat | tetrachloromethane | increases expression | ISO | RGD:1320663 | 6480464 | Carbon Tetrachloride results in increased expression of SHLD2 mRNA | CTD | PMID:31919559 | Shld2 | Rat | tetraphene | decreases expression | ISO | RGD:1320663 | 6480464 | benz(a)anthracene results in decreased expression of SHLD2 mRNA | CTD | PMID:26377693 | Shld2 | Rat | thiram | decreases expression | ISO | RGD:1354134 | 6480464 | Thiram results in decreased expression of SHLD2 mRNA | CTD | PMID:38568856 | Shld2 | Rat | triphenyl phosphate | affects expression | ISO | RGD:1354134 | 6480464 | triphenyl phosphate affects the expression of SHLD2 mRNA | CTD | PMID:37042841 | Shld2 | Rat | ursodeoxycholic acid | affects expression | ISO | RGD:1354134 | 6480464 | Ursodeoxycholic Acid affects the expression of SHLD2 mRNA | CTD | PMID:18422935 | Shld2 | Rat | valproic acid | increases methylation | ISO | RGD:1354134 | 6480464 | Valproic Acid results in increased methylation of SHLD2 gene | CTD | PMID:29154799 | Shld2 | Rat | valproic acid | decreases expression | ISO | RGD:1354134 | 6480464 | Valproic Acid results in decreased expression of SHLD2 mRNA | CTD | PMID:23179753 | Shld2 | Rat | valproic acid | decreases expression | ISO | RGD:1320663 | 6480464 | Valproic Acid results in decreased expression of SHLD2 mRNA | CTD | PMID:24535564 | |