Ces2i (carboxylesterase 2I) - Rat Genome Database

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Gene: Ces2i (carboxylesterase 2I) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ces2i
Name: carboxylesterase 2I
RGD ID: 1565045
Description: Predicted to enable carboxylic ester hydrolase activity. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human CES2 (carboxylesterase 2); INTERACTS WITH tetrachloromethane; thioacetamide; trichloroethene.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC292152; pyrethroid hydrolase Ces2a; RGD1565045; similar to carboxylesterase isoenzyme gene
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81270,307,613 - 270,315,126 (+)NCBIGRCr8
mRatBN7.21260,321,595 - 260,329,110 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1260,321,595 - 260,328,987 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01282,569,926 - 282,575,202 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1282,567,674 - 282,575,276 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01289,903,227 - 289,910,626 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41267,807,848 - 267,815,238 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1255,961,416 - 255,968,686 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, etal., Mamm Genome. 2010 Oct;21(9-10):427-41. Epub 2010 Oct 8.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Ces2i
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:162
Count of miRNA genes:130
Interacting mature miRNAs:141
Transcripts:ENSRNOT00000015997
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
71112Bw115Body weight QTL 11560.0001body mass (VT:0001259)body weight (CMO:0000012)1259647732260522016Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium 13 13 13
Low 3 10 10 10 2 1
Below cutoff 16 12 1 12 2 1 21 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015997   ⟹   ENSRNOP00000015997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1282,568,287 - 282,575,276 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090543   ⟹   ENSRNOP00000071888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1260,321,595 - 260,328,987 (+)Ensembl
Rnor_6.0 Ensembl1282,567,674 - 282,575,061 (+)Ensembl
RefSeq Acc Id: XM_008760594   ⟹   XP_008758816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81270,307,613 - 270,315,126 (+)NCBI
mRatBN7.21260,321,595 - 260,329,110 (+)NCBI
Rnor_6.01282,569,926 - 282,575,202 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039096792   ⟹   XP_038952720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81270,307,613 - 270,315,126 (+)NCBI
mRatBN7.21260,321,595 - 260,329,110 (+)NCBI
RefSeq Acc Id: XM_039096795   ⟹   XP_038952723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81270,307,613 - 270,315,126 (+)NCBI
mRatBN7.21260,321,595 - 260,329,110 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008758816 (Get FASTA)   NCBI Sequence Viewer  
  XP_038952720 (Get FASTA)   NCBI Sequence Viewer  
  XP_038952723 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071888
  ENSRNOP00000071888.2
Reference Protein Sequences
RefSeq Acc Id: XP_008758816   ⟸   XM_008760594
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K1L3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071888   ⟸   ENSRNOT00000090543
RefSeq Acc Id: ENSRNOP00000015997   ⟸   ENSRNOT00000015997
RefSeq Acc Id: XP_038952723   ⟸   XM_039096795
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K1L3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952720   ⟸   XM_039096792
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K1L3 (UniProtKB/TrEMBL)
Protein Domains
Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K1L3-F1-model_v2 AlphaFold A0A0G2K1L3 1-558 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691027
Promoter ID:EPDNEW_R1551
Type:single initiation site
Name:Ces2i_1
Description:carboxylesterase 2I
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01282,567,643 - 282,567,703EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565045 AgrOrtholog
BioCyc Gene G2FUF-55211 BioCyc
Ensembl Genes ENSRNOG00000012034 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090543 ENTREZGENE
  ENSRNOT00000090543.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/TrEMBL
  Carboxylesterase_B_AS UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/TrEMBL
NCBI Gene 292152 ENTREZGENE
PANTHER CARBOXYLESTERASE UniProtKB/TrEMBL
  PYRETHROID HYDROLASE CES2A UniProtKB/TrEMBL
Pfam COesterase UniProtKB/TrEMBL
PhenoGen Ces2i PhenoGen
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/TrEMBL
  CARBOXYLESTERASE_B_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012034 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A0G2K1L3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-11-18 Ces2i  carboxylesterase 2I  RGD1565045  similar to carboxylesterase isoenzyme gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565045  similar to carboxylesterase isoenzyme gene   RGD1565045_predicted  similar to carboxylesterase isoenzyme gene (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565045_predicted  similar to carboxylesterase isoenzyme gene (predicted)  LOC292152  similar to carboxylesterase isoenzyme gene  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC292152  similar to carboxylesterase isoenzyme gene      Symbol and Name status set to provisional 70820 PROVISIONAL