Phip (pleckstrin homology domain interacting protein)

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Gene: Phip (pleckstrin homology domain interacting protein) Rattus norvegicus

Analyze

Symbol:

Phip

Name:

pleckstrin homology domain interacting protein

RGD ID:

1564964

Description:

Predicted to enable lysine-acetylated histone binding activity. Predicted to be involved in several processes, including positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of mitotic nuclear division; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including insulin receptor signaling pathway; positive regulation of cell population proliferation; and positive regulation of protein phosphorylation. Predicted to be active in nucleus. Orthologous to human PHIP (pleckstrin homology domain interacting protein); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

hypothetical protein LOC315843; LOC315843; PH-interacting protein; RGD1564964; similar to WD repeat domain 11 protein; uncharacterized protein LOC315843

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	83,776,802 - 83,891,192 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	83,781,465 - 83,894,283 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	8	90,387,339 - 90,483,964 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	90,392,143 - 90,483,077 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	89,916,080 - 90,014,067 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	88,009,896 - 88,060,553 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	8	83,437,217 - 83,536,036 (-)	NCBI		Celera
Cytogenetic Map	8	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

autistic disorder (ISO)

DEVELOPMENTAL DELAY, INTELLECTUAL DISABILITY, OBESITY, AND DYSMORPHIC FEATURES (ISO)

Developmental Disease (ISO)

genetic disease (ISO)

INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED, SYNDROMIC, SNIJDERS BLOK TYPE (ISO)

intellectual disability (ISO)

maple syrup urine disease (ISO)

Neurodevelopmental Disorders (ISO)

Sjogren's syndrome (ISO)

syndromic intellectual disability (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

aflatoxin B1 (ISO)

aflatoxin M1 (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

caffeine (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

chloroprene (EXP)

chlorpyrifos (ISO)

cisplatin (ISO)

clorgyline (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

crocidolite asbestos (ISO)

decabromodiphenyl ether (ISO)

dibutyl phthalate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

folic acid (ISO)

formaldehyde (ISO)

methyl methanesulfonate (ISO)

oxaliplatin (EXP)

panobinostat (ISO)

PCB138 (ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

piroxicam (ISO)

potassium chromate (ISO)

resveratrol (ISO)

rimonabant (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

succimer (ISO)

thapsigargin (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trichostatin A (ISO)

triphenyl phosphate (EXP)

triptonide (ISO)

troglitazone (ISO)

tungsten (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell population proliferation (ISO)

cytoskeleton organization (IBA,ISO)

fibroblast proliferation (ISO)

insulin receptor signaling pathway (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of extrinsic apoptotic signaling pathway (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of fibroblast proliferation (ISO)

positive regulation of insulin-like growth factor receptor signaling pathway (ISO)

positive regulation of mitotic nuclear division (ISO)

positive regulation of peptidyl-serine phosphorylation (ISO)

positive regulation of peptidyl-threonine phosphorylation (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

positive regulation of type B pancreatic cell proliferation (ISO)

protein import into nucleus (ISO)

regulation of cell morphogenesis (ISO)

regulation of cell shape (IBA)

regulation of growth (ISO)

regulation of protein phosphorylation (ISO)

regulation of transcription by RNA polymerase II (IBA)

type B pancreatic cell proliferation (ISO)

Cellular Component

nucleus (IBA,ISO)

Molecular Function

lysine-acetylated histone binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11018022	PMID:12242307	PMID:17636024	PMID:20816727	PMID:21834987	PMID:22464331	PMID:23376485

Genomics

Comparative Map Data

Phip
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	83,776,802 - 83,891,192 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	83,781,465 - 83,894,283 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	8	90,387,339 - 90,483,964 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	90,392,143 - 90,483,077 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	89,916,080 - 90,014,067 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	88,009,896 - 88,060,553 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	8	83,437,217 - 83,536,036 (-)	NCBI		Celera
Cytogenetic Map	8	q31	NCBI

PHIP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	78,934,419 - 79,078,254 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	78,934,419 - 79,078,287 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	79,644,136 - 79,787,971 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	79,706,985 - 79,844,708 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	79,707,001 - 79,844,708	NCBI
Celera	6	80,031,409 - 80,175,293 (-)	NCBI		Celera
Cytogenetic Map	6	q14.1	NCBI
HuRef	6	76,837,993 - 76,981,618 (-)	NCBI		HuRef
CHM1_1	6	79,741,711 - 79,885,530 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	80,112,128 - 80,255,969 (-)	NCBI		T2T-CHM13v2.0

Phip
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	82,748,212 - 82,857,776 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	82,748,212 - 82,857,569 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	82,866,159 - 82,981,668 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	82,866,159 - 82,975,516 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	82,759,766 - 82,869,096 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	82,662,877 - 82,772,207 (-)	NCBI		MGSCv36	mm8
Celera	9	79,960,082 - 80,068,701 (-)	NCBI		Celera
Cytogenetic Map	9	E2	NCBI
cM Map	9	45.18	NCBI

Phip
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955502	6,842,149 - 6,935,263 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955502	6,842,149 - 6,951,791 (-)	NCBI	ChiLan1.0	ChiLan1.0

PHIP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	6	96,872,217 - 97,014,485 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	76,785,886 - 76,929,475 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	80,058,059 - 80,186,787 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	80,064,340 - 80,184,036 (-)	Ensembl	panpan1.1		panPan2

PHIP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	39,899,738 - 40,015,795 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	39,904,603 - 40,032,194 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	39,773,107 - 39,905,224 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	40,671,860 - 40,803,758 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	40,674,679 - 40,803,670 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	39,993,134 - 40,125,018 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	39,971,723 - 40,103,648 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	40,102,603 - 40,234,495 (-)	NCBI		UU_Cfam_GSD_1.0

Phip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	75,272,412 - 75,394,105 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936510	11,076,785 - 11,193,689 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936510	11,076,790 - 11,198,483 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PHIP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	87,117,092 - 87,243,675 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	87,116,884 - 87,247,500 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	97,888,778 - 98,018,039 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PHIP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	3,646,331 - 3,783,930 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	3,651,161 - 3,783,160 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	179,872,537 - 180,010,986 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Phip
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624819	5,608,019 - 5,720,121 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624819	5,603,334 - 5,675,664 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Phip
449 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	18
Count of miRNA genes:	17
Interacting mature miRNAs:	18
Transcripts:	ENSRNOT00000011864
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
631271	Lecl1	Lens clarity QTL 1		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	8	18984168	84531599	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	19331152	93965294	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	27205715	99103503	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	27205715	99103503	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	27205715	99103503	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	28242912	99525068	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	30188867	94457446	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	30848154	101699754	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	30848154	101699754	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	30848154	101699754	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	30848259	105647037	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	36469535	99083736	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	40713066	93965294	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	41866876	86866876	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	42692684	90165460	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	43296169	98968765	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	43296169	98968765	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	43296169	98968765	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	43296169	98968765	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	43296169	98968765	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	43296169	98968765	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	46531722	99083736	Rat
2303570	Gluco48	Glucose level QTL 48	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	49805831	94805831	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	51351728	107062046	Rat
10402857	Bp380	Blood pressure QTL 380		0.95	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	53968765	98968765	Rat
2301402	Bp316	Blood pressure QTL 316		0.005	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	53968765	98968765	Rat
2293697	Bmd39	Bone mineral density QTL 39			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	8	54043744	98968765	Rat
1582243	Bw66	Body weight QTL 66	3.4	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	8	54237644	85365202	Rat
1582254	Kidm31	Kidney mass QTL 31	3		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	8	54237644	85365202	Rat
631664	Hcar3	Hepatocarcinoma resistance QTL 3	2.9	0.0005	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	8	54237644	99103503	Rat
1300177	Cm2	Cardiac mass QTL 2	3.65		heart mass (VT:0007028)	heart weight (CMO:0000017)	8	54259986	100382532	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
631653	Bp125	Blood pressure QTL 125	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	66142385	111142385	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	69349194	112783834	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	70513503	118219066	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	71888757	116888757	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	71888757	116888757	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	71888757	116888757	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	71888757	116888757	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	73473045	118473045	Rat
10450865	Bw175	Body weight QTL 175	4.1		total fat pad mass (VT:0015008)	adipose tissue molecular composition measurement (CMO:0000484)	8	75311777	84531599	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	76468691	121468691	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat

Markers in Region

BF395970

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	83,786,711 - 83,787,470 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	90,397,249 - 90,398,007	NCBI	Rnor6.0
Rnor_5.0	8	89,925,990 - 89,926,748	UniSTS	Rnor5.0
RGSC_v3.4	8	88,016,662 - 88,017,420	UniSTS	RGSC3.4
Celera	8	83,447,127 - 83,447,885	UniSTS
RH 3.4 Map	8	965.7	UniSTS
Cytogenetic Map	8	q31	UniSTS

RH139219

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	83,781,513 - 83,781,701 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	90,392,051 - 90,392,238	NCBI	Rnor6.0
Rnor_5.0	8	89,920,792 - 89,920,979	UniSTS	Rnor5.0
RGSC_v3.4	8	88,011,464 - 88,011,651	UniSTS	RGSC3.4
Celera	8	83,441,929 - 83,442,116	UniSTS
RH 3.4 Map	8	963.6	UniSTS
Cytogenetic Map	8	q31	UniSTS

MARC_15335-15336:1013436983:1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	83,841,654 - 83,842,688 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	90,451,647 - 90,452,680	NCBI	Rnor6.0
Rnor_5.0	8	89,980,950 - 89,981,983	UniSTS	Rnor5.0
Celera	8	83,502,040 - 83,503,073	UniSTS
Cytogenetic Map	8	q31	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	32	32	16	19	16	8	8	74	28	37	11	8
Low	1	11	25	25		25		3		7	4
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003754471	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243470	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082538	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082539	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082540	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082541	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082542	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214926	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ233636	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000199	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000011864 ⟹ ENSRNOP00000011864

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	83,781,465 - 83,894,283 (-)	Ensembl
Rnor_6.0 Ensembl	8	90,392,143 - 90,483,077 (-)	Ensembl

RefSeq Acc Id:

XM_039082538 ⟹ XP_038938466

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	83,776,802 - 83,891,189 (-)	NCBI

RefSeq Acc Id:

XM_039082539 ⟹ XP_038938467

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	83,776,802 - 83,891,192 (-)	NCBI

RefSeq Acc Id:

XM_039082540 ⟹ XP_038938468

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	83,776,802 - 83,868,671 (-)	NCBI

RefSeq Acc Id:

XM_039082541 ⟹ XP_038938469

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	83,776,802 - 83,855,589 (-)	NCBI

RefSeq Acc Id:

XM_039082542 ⟹ XP_038938470

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	83,787,688 - 83,891,189 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_038938466	(Get FASTA)	NCBI Sequence Viewer
	XP_038938467	(Get FASTA)	NCBI Sequence Viewer
	XP_038938468	(Get FASTA)	NCBI Sequence Viewer
	XP_038938469	(Get FASTA)	NCBI Sequence Viewer
	XP_038938470	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL77672	(Get FASTA)	NCBI Sequence Viewer
	EDL77673	(Get FASTA)	NCBI Sequence Viewer
	EDL77674	(Get FASTA)	NCBI Sequence Viewer
	EDL77675	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

ENSRNOP00000011864 ⟸ ENSRNOT00000011864

RefSeq Acc Id:	XP_038938467 ⟸ XM_039082539
- Peptide Label:	isoform X2
- UniProtKB:	F1M3B3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038938466 ⟸ XM_039082538
- Peptide Label:	isoform X1
- UniProtKB:	F1M3B3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038938468 ⟸ XM_039082540
- Peptide Label:	isoform X3
- UniProtKB:	F1M3B3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038938469 ⟸ XM_039082541
- Peptide Label:	isoform X4
- UniProtKB:	F1M3B3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038938470 ⟸ XM_039082542
- Peptide Label:	isoform X5

Protein Domains

Bromo

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M3B3-F1-model_v2	AlphaFold	F1M3B3	1-1758	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564964	AgrOrtholog
BioCyc Gene	G2FUF-29711	BioCyc
Ensembl Genes	ENSRNOG00000008652	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000011864	ENTREZGENE
	ENSRNOP00000011864.7	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000011864	ENTREZGENE
	ENSRNOT00000011864.7	UniProtKB/TrEMBL
Gene3D-CATH	1.20.920.10	UniProtKB/TrEMBL
	2.130.10.10	UniProtKB/TrEMBL
InterPro	Bromodomain	UniProtKB/TrEMBL
	Bromodomain-like_sf	UniProtKB/TrEMBL
	Bromodomain_CS	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
NCBI Gene	315843	ENTREZGENE
PANTHER	PTHR16266:SF4	UniProtKB/TrEMBL
	WD REPEAT DOMAIN 9	UniProtKB/TrEMBL
Pfam	Bromodomain	UniProtKB/TrEMBL
	WD40	UniProtKB/TrEMBL
PhenoGen	Phip	PhenoGen
PRINTS	BROMODOMAIN	UniProtKB/TrEMBL
PROSITE	BROMODOMAIN_1	UniProtKB/TrEMBL
	BROMODOMAIN_2	UniProtKB/TrEMBL
	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
SMART	BROMO	UniProtKB/TrEMBL
	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	Bromodomain	UniProtKB/TrEMBL
	WD40_like	UniProtKB/TrEMBL
UniProt	F1M3B3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-12	Phip	pleckstrin homology domain interacting protein	RGD1564964	similar to WD repeat domain 11 protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1564964	similar to WD repeat domain 11 protein	RGD1564964_predicted	similar to WD repeat domain 11 protein (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1564964_predicted	similar to WD repeat domain 11 protein (predicted)	LOC315843	similar to WD repeat domain 11 protein	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC315843	similar to WD repeat domain 11 protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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