Ubl5 (ubiquitin-like 5) - Rat Genome Database

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Gene: Ubl5 (ubiquitin-like 5) Rattus norvegicus
Analyze
Symbol: Ubl5
Name: ubiquitin-like 5
RGD ID: 1564644
Description: Predicted to enable protein tag activity. Predicted to be involved in mRNA splicing, via spliceosome and positive regulation of protein targeting to mitochondrion. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBL5 (ubiquitin like 5); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beacon; LOC500954; Ubiquitin-Like 5 Protein; ubiquitin-like protein 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,457,738 - 27,461,458 (+)NCBIGRCr8
mRatBN7.2819,181,504 - 19,185,224 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,181,615 - 19,185,217 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,201,812 - 23,205,536 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,499,651 - 21,503,375 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,411,250 - 19,414,970 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0821,663,257 - 21,665,049 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,663,325 - 21,665,038 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0821,719,122 - 21,721,110 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4819,663,626 - 19,665,339 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera820,578,802 - 20,580,515 (+)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11161819   PMID:15942675   PMID:16157417   PMID:17097194   PMID:24270810  


Genomics

Comparative Map Data
Ubl5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,457,738 - 27,461,458 (+)NCBIGRCr8
mRatBN7.2819,181,504 - 19,185,224 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,181,615 - 19,185,217 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,201,812 - 23,205,536 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,499,651 - 21,503,375 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,411,250 - 19,414,970 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0821,663,257 - 21,665,049 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,663,325 - 21,665,038 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0821,719,122 - 21,721,110 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4819,663,626 - 19,665,339 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera820,578,802 - 20,580,515 (+)NCBICelera
Cytogenetic Map8q13NCBI
UBL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38199,827,918 - 9,830,115 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl199,827,892 - 9,830,115 (+)EnsemblGRCh38hg38GRCh38
GRCh37199,938,594 - 9,940,791 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36199,799,568 - 9,801,797 (+)NCBINCBI36Build 36hg18NCBI36
Build 34199,799,613 - 9,801,791NCBI
Celera199,833,993 - 9,836,222 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef199,519,189 - 9,521,430 (+)NCBIHuRef
CHM1_1199,938,269 - 9,940,510 (+)NCBICHM1_1
T2T-CHM13v2.0199,953,519 - 9,956,279 (+)NCBIT2T-CHM13v2.0
Ubl5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39920,554,013 - 20,558,436 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl920,554,174 - 20,558,436 (+)EnsemblGRCm39 Ensembl
GRCm38920,642,717 - 20,647,140 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl920,642,878 - 20,647,140 (+)EnsemblGRCm38mm10GRCm38
MGSCv37920,447,762 - 20,451,233 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,393,720 - 20,397,191 (+)NCBIMGSCv36mm8
Celera917,913,763 - 17,917,234 (+)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.6NCBI
Ubl5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,242,733 - 1,244,238 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,242,733 - 1,244,238 (+)NCBIChiLan1.0ChiLan1.0
UBL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22014,746,291 - 14,748,891 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11913,749,258 - 13,751,463 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,382,423 - 9,384,710 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,045,605 - 10,047,697 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,045,636 - 10,047,697 (+)Ensemblpanpan1.1panPan2
UBL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12051,174,741 - 51,176,401 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2051,174,741 - 51,176,292 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2051,038,534 - 51,040,198 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,696,125 - 51,697,789 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,696,125 - 51,697,676 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,903,731 - 50,905,395 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02051,328,193 - 51,329,859 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,569,994 - 51,571,658 (-)NCBIUU_Cfam_GSD_1.0
Ubl5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118210,049,581 - 210,051,242 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659303,252 - 305,122 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936659303,279 - 305,125 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl268,706,197 - 68,708,011 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1268,702,478 - 68,708,012 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,035,905 - 69,037,795 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UBL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.168,899,889 - 8,902,462 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl68,899,970 - 8,902,459 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607411,187,078 - 11,189,647 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ubl5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,112,794 - 2,114,392 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,112,694 - 2,114,392 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ubl5
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:79
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000027749
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat

Markers in Region
RH130060  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,184,054 - 19,185,164 (+)MAPPERmRatBN7.2
Rnor_6.0821,663,883 - 21,664,992NCBIRnor6.0
Rnor_5.0821,719,944 - 21,721,053UniSTSRnor5.0
RGSC_v3.4819,664,184 - 19,665,293UniSTSRGSC3.4
Celera820,579,360 - 20,580,469UniSTS
Cytogenetic Map8q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027749   ⟹   ENSRNOP00000027749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl821,663,325 - 21,665,038 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101563   ⟹   ENSRNOP00000097218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,181,615 - 19,185,217 (+)Ensembl
RefSeq Acc Id: NM_001048243   ⟹   NP_001041708
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,459,665 - 27,461,458 (+)NCBI
mRatBN7.2819,183,431 - 19,185,224 (+)NCBI
Rnor_6.0821,663,325 - 21,665,038 (+)NCBI
Rnor_5.0821,719,122 - 21,721,110 (+)NCBI
RGSC_v3.4819,663,626 - 19,665,339 (+)RGD
Celera820,578,802 - 20,580,515 (+)RGD
Sequence:
RefSeq Acc Id: NM_001393882   ⟹   NP_001380811
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,459,665 - 27,461,458 (+)NCBI
mRatBN7.2819,183,431 - 19,185,224 (+)NCBI
RefSeq Acc Id: NM_001393883   ⟹   NP_001380812
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,457,738 - 27,461,458 (+)NCBI
mRatBN7.2819,181,504 - 19,185,224 (+)NCBI
RefSeq Acc Id: XM_063265961   ⟹   XP_063122031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,459,680 - 27,461,444 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001041708   ⟸   NM_001048243
- UniProtKB: A9UMW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027749   ⟸   ENSRNOT00000027749
RefSeq Acc Id: ENSRNOP00000097218   ⟸   ENSRNOT00000101563
RefSeq Acc Id: NP_001380812   ⟸   NM_001393883
- UniProtKB: A9UMW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380811   ⟸   NM_001393882
- UniProtKB: A9UMW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122031   ⟸   XM_063265961
- Peptide Label: isoform X1
Protein Domains
Ubiquitin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A9UMW0-F1-model_v2 AlphaFold A9UMW0 1-73 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695760
Promoter ID:EPDNEW_R6285
Type:initiation region
Name:Ubl5_1
Description:ubiquitin-like 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0821,663,290 - 21,663,350EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564644 AgrOrtholog
BioCyc Gene G2FUF-31467 BioCyc
Ensembl Genes ENSRNOG00000020442 Ensembl
  ENSRNOG00000069661 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000101563.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7936655 IMAGE-MGC_LOAD
InterPro Hub1/Ubl5 UniProtKB/TrEMBL
  Ubiquitin UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
KEGG Report rno:500954 UniProtKB/TrEMBL
MGC_CLONE MGC:188356 IMAGE-MGC_LOAD
NCBI Gene 500954 ENTREZGENE
PANTHER PTHR13042 UniProtKB/TrEMBL
  UBIQUITIN-LIKE PROTEIN 5 UniProtKB/TrEMBL
Pfam ubiquitin UniProtKB/TrEMBL
PhenoGen Ubl5 PhenoGen
RatGTEx ENSRNOG00000020442 RatGTEx
  ENSRNOG00000069661 RatGTEx
Superfamily-SCOP SSF54236 UniProtKB/TrEMBL
UniProt A0A8I6AUP1_RAT UniProtKB/TrEMBL
  A9UMW0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Ubl5  ubiquitin-like 5  LOC500954  Ubiquitin-Like 5 Protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC500954  Ubiquitin-Like 5 Protein      Symbol and Name status set to provisional 70820 PROVISIONAL