Nek10 (NIMA-related kinase 10) - Rat Genome Database
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Gene: Nek10 (NIMA-related kinase 10) Rattus norvegicus
Analyze
Symbol: Nek10
Name: NIMA-related kinase 10
RGD ID: 1564342
Description: Predicted to have protein serine/threonine kinase activity. Predicted to be involved in several processes, including mucociliary clearance; regulation of cell cycle G2/M phase transition; and regulation of protein phosphorylation. Predicted to localize to protein kinase complex. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 44. Orthologous to human NEK10 (NIMA related kinase 10); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; amphetamine.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC305710; LOW QUALITY PROTEIN: serine/threonine-protein kinase Nek10; NIMA (never in mitosis gene a)- related kinase 10; RGD1564342; serine/threonine-protein kinase Nek10; similar to hypothetical protein FLJ32685
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21510,387,063 - 10,564,177 (-)NCBI
Rnor_6.0 Ensembl1511,632,759 - 11,812,485 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01511,627,133 - 11,830,647 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01515,665,846 - 15,869,347 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41511,865,467 - 12,045,333 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1510,388,639 - 10,594,725 (-)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:20956560  


Genomics

Comparative Map Data
Nek10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21510,387,063 - 10,564,177 (-)NCBI
Rnor_6.0 Ensembl1511,632,759 - 11,812,485 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01511,627,133 - 11,830,647 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01515,665,846 - 15,869,347 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41511,865,467 - 12,045,333 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1510,388,639 - 10,594,725 (-)NCBICelera
Cytogenetic Map15p16NCBI
NEK10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl327,110,085 - 27,369,460 (-)EnsemblGRCh38hg38GRCh38
GRCh38327,107,336 - 27,369,460 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37327,152,394 - 27,410,874 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37327,257,097 - 27,410,912 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36327,127,398 - 27,307,988 (-)NCBINCBI36hg18NCBI36
Celera327,193,380 - 27,347,291 (-)NCBI
Cytogenetic Map3p24.1NCBI
HuRef327,200,250 - 27,354,087 (-)NCBIHuRef
CHM1_1327,102,338 - 27,360,939 (-)NCBICHM1_1
Nek10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39147,457,704 - 7,666,183 (-)NCBIGRCm39mm39
GRCm381414,803,580 - 15,012,059 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1414,803,415 - 15,012,059 (+)EnsemblGRCm38mm10GRCm38
MGSCv371415,653,329 - 15,839,207 (+)NCBIGRCm37mm9NCBIm37
MGSCv361415,697,736 - 15,804,174 (+)NCBImm8
Celera1410,485,404 - 10,622,474 (+)NCBICelera
Cytogenetic Map14A1NCBI
Nek10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543018,754,292 - 18,988,771 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543018,754,292 - 18,988,716 (-)NCBIChiLan1.0ChiLan1.0
NEK10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1327,330,021 - 27,584,340 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl327,330,021 - 27,584,340 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0327,002,397 - 27,257,856 (-)NCBIMhudiblu_PPA_v0panPan3
NEK10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2316,805,117 - 17,008,419 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12316,802,052 - 17,014,212 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nek10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647318,341,867 - 18,548,966 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEK10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1313,751,726 - 13,930,483 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11313,751,178 - 13,931,896 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21315,303,339 - 15,476,157 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NEK10
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11571,687,799 - 71,938,573 (-)NCBI
Nek10
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247884,965,391 - 5,237,142 (-)NCBI

Position Markers
RH140518  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01511,652,013 - 11,652,205NCBIRnor6.0
Rnor_6.0514,511,312 - 14,511,454NCBIRnor6.0
Rnor_5.01515,690,726 - 15,690,918UniSTSRnor5.0
Rnor_5.0519,293,611 - 19,293,753UniSTSRnor5.0
RGSC_v3.41511,881,548 - 11,881,740UniSTSRGSC3.4
RGSC_v3.4514,834,174 - 14,834,316UniSTSRGSC3.4
Celera1510,413,518 - 10,413,710UniSTS
Celera514,002,802 - 14,002,944UniSTS
Cytogenetic Map5q12UniSTS
Cytogenetic Map15p16UniSTS
RH132340  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01511,630,185 - 11,630,395NCBIRnor6.0
Rnor_5.01515,668,898 - 15,669,108UniSTSRnor5.0
RGSC_v3.41511,859,720 - 11,859,930UniSTSRGSC3.4
Celera1510,391,691 - 10,391,901UniSTS
RH 3.4 Map1593.53UniSTS
Cytogenetic Map15p16UniSTS
RH141473  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01511,651,324 - 11,651,473NCBIRnor6.0
Rnor_6.0514,511,994 - 14,512,143NCBIRnor6.0
Rnor_5.01515,690,037 - 15,690,186UniSTSRnor5.0
Rnor_5.0519,294,293 - 19,294,442UniSTSRnor5.0
RGSC_v3.41511,880,859 - 11,881,008UniSTSRGSC3.4
RGSC_v3.4514,834,856 - 14,835,005UniSTSRGSC3.4
Celera1510,412,829 - 10,412,978UniSTS
Celera514,003,484 - 14,003,633UniSTS
Cytogenetic Map15p16UniSTS
Cytogenetic Map5q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300142Bp191Blood pressure QTL 1913.14arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)15112800829Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15130597196Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15137708474Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15137708474Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15137708474Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15142844179Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15143521446Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15162301382Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15110589015828368Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)colorectal tumor number (CMO:0001794)15232787726288802Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15232787726288802Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15232787753535766Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15388113148881131Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151071919155719191Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:58
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000007795, ENSRNOT00000030991
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 1
Low 6 15 18 7 9 46 2 19 10 7
Below cutoff 3 19 15 14 1 14 1 2 22 30 14 1

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_039093745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACYVU010000260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000007795   ⟹   ENSRNOP00000007795
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1511,635,932 - 11,812,485 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000030991   ⟹   ENSRNOP00000031133
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1511,632,759 - 11,812,485 (-)Ensembl
RefSeq Acc Id: XM_006251721   ⟹   XP_006251783
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01511,627,133 - 11,830,647 (-)NCBI
Rnor_5.01515,665,846 - 15,869,347 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767542   ⟹   XP_008765764
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera1510,388,639 - 10,594,725 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767545   ⟹   XP_008765767
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera1510,388,639 - 10,562,144 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770599   ⟹   XP_008768821
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01511,627,133 - 11,798,394 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599840   ⟹   XP_017455329
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01511,627,133 - 11,830,088 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093745   ⟹   XP_038949673
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21510,387,063 - 10,564,177 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038949673 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_006251783   ⟸   XM_006251721
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008765764   ⟸   XM_008767542
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008765767   ⟸   XM_008767545
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008768821   ⟸   XM_008770599
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017455329   ⟸   XM_017599840
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000007795   ⟸   ENSRNOT00000007795
RefSeq Acc Id: ENSRNOP00000031133   ⟸   ENSRNOT00000030991
RefSeq Acc Id: XP_038949673   ⟸   XM_039093745
Protein Domains
Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
15 15689195 15689196 A T snv ACI/EurMcwi (MCW), Crl:SD (UDEL), FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), ACI/N (KNAW), ACI/EurMcwi (KNAW), GH/OmrMcwi (MCW), MNS/Gib (KNAW), M520/N (KNAW), FHL/EurMcwi (KNAW), FHH/EurMcwi (KNAW), DA/BklArbNsi (KNAW)
15 15689252 15689253 A G snv WKY/NCrl (KNAW), WKY/Gcrc (KNAW), WKY/N (KNAW), GK/Ox (KNAW), WKY/NHsd (KNAW)
15 15689558 15689559 G A snv WKY/Gcrc (KNAW), GK/Ox (KNAW), WKY/N (KNAW), WKY/NCrl (KNAW), WKY/NHsd (KNAW)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
15 11650482 11650483 A T snv ACI/EurMcwi (MCW), GH/OmrMcwi (MCW), FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), ACI/N (MCW), M520/N (MCW)
15 11650845 11650846 G A snv WKY/N (MCW), GK/Ox (RGD), WKY/NCrl (RGD)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564342 AgrOrtholog
Ensembl Genes ENSRNOG00000005883 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000007795 UniProtKB/TrEMBL
  ENSRNOP00000031133 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007795 UniProtKB/TrEMBL
  ENSRNOT00000030991 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Nek10_STKc UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Tyr_prot_kinase_AS UniProtKB/TrEMBL
NCBI Gene 305710 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Nek10 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
UniProt D3ZFA2_RAT UniProtKB/TrEMBL
  D4A5Z9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-21 Nek10  NIMA-related kinase 10  Nek10  NIMA (never in mitosis gene a)- related kinase 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-12 Nek10  NIMA (never in mitosis gene a)- related kinase 10  RGD1564342  similar to hypothetical protein FLJ32685  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1564342  similar to hypothetical protein FLJ32685   RGD1564342_predicted  similar to hypothetical protein FLJ32685 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564342_predicted  similar to hypothetical protein FLJ32685 (predicted)  LOC305710  similar to hypothetical protein FLJ32685  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC305710  similar to hypothetical protein FLJ32685      Symbol and Name status set to provisional 70820 PROVISIONAL