Nek10 (NIMA-related kinase 10) - Rat Genome Database

Name: Nek10
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Nek10 (NIMA-related kinase 10) Rattus norvegicus

Analyze

Symbol:

Nek10

Name:

NIMA-related kinase 10

RGD ID:

1564342

Description:

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including mucociliary clearance; positive regulation of protein phosphorylation; and regulation of ERK1 and ERK2 cascade. Predicted to be located in extracellular region. Predicted to be part of protein kinase complex. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 44. Orthologous to human NEK10 (NIMA related kinase 10); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; amphetamine.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC305710; NIMA (never in mitosis gene a)- related kinase 10; RGD1564342; serine/threonine-protein kinase Nek10; similar to hypothetical protein FLJ32685

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NEK10 (NIMA related kinase 10)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Nek10 (NIMA (never in mitosis gene a)- related kinase 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nek10 (NIMA related kinase 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NEK10 (NIMA related kinase 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NEK10 (NIMA related kinase 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nek10 (NIMA related kinase 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NEK10 (NIMA related kinase 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NEK10 (NIMA related kinase 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nek10 (NIMA related kinase 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	NEK10 (NIMA related kinase 10)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Nek10 (NIMA (never in mitosis gene a)- related kinase 10)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nek10 (NIMA-related kinase 10)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	nekl-4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	nek10	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	15	10,387,063 - 10,564,177 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	10,381,140 - 10,559,722 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	15	11,627,133 - 11,830,647 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	11,632,759 - 11,812,485 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	15,665,846 - 15,869,347 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	11,865,467 - 12,045,333 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	15	10,388,639 - 10,594,725 (-)	NCBI		Celera
Cytogenetic Map	15	p16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

primary ciliary dyskinesia 44 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

aflatoxin B1 (ISO)

amphetamine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

copper(II) sulfate (ISO)

fulvestrant (ISO)

gallic acid (ISO)

methamphetamine (EXP)

propanal (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mucociliary clearance (ISO)

positive regulation of MAP kinase activity (IBA,ISO)

positive regulation of protein autophosphorylation (ISO)

protein phosphorylation (ISO)

regulation of cell cycle G2/M phase transition (IBA,ISO)

regulation of ERK1 and ERK2 cascade (ISO)

Cellular Component

extracellular region (IEA)

protein kinase complex (ISO)

Molecular Function

ATP binding (IEA)

protein kinase activity (ISO)

protein serine/threonine kinase activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:20956560

Genomics

Comparative Map Data

Nek10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	15	10,387,063 - 10,564,177 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	10,381,140 - 10,559,722 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	15	11,627,133 - 11,830,647 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	11,632,759 - 11,812,485 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	15,665,846 - 15,869,347 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	11,865,467 - 12,045,333 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	15	10,388,639 - 10,594,725 (-)	NCBI		Celera
Cytogenetic Map	15	p16	NCBI

NEK10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	27,106,484 - 27,369,383 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	3	27,106,484 - 27,369,460 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	27,147,975 - 27,410,874 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	27,127,398 - 27,307,988 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	3	27,193,380 - 27,347,291 (-)	NCBI		Celera
Cytogenetic Map	3	p24.1	NCBI
HuRef	3	27,200,250 - 27,354,087 (-)	NCBI		HuRef
CHM1_1	3	27,207,083 - 27,360,900 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	27,108,644 - 27,371,532 (-)	NCBI		T2T-CHM13v2.0

Nek10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	7,457,704 - 7,666,183 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	7,457,704 - 7,666,348 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	14,803,580 - 15,012,059 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	14,803,415 - 15,012,059 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	15,653,329 - 15,839,207 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	15,697,736 - 15,804,174 (+)	NCBI		MGSCv36	mm8
Celera	14	10,485,404 - 10,622,474 (+)	NCBI		Celera
Cytogenetic Map	14	A1	NCBI

Nek10
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955430	18,754,292 - 18,988,771 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955430	18,754,292 - 18,988,716 (-)	NCBI	ChiLan1.0	ChiLan1.0

NEK10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	3	27,060,499 - 27,304,530 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	27,002,397 - 27,257,856 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	27,330,021 - 27,584,340 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	27,330,021 - 27,584,340 (-)	Ensembl	panpan1.1		panPan2

NEK10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	16,802,052 - 17,014,212 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	16,805,117 - 17,008,419 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	16,784,109 - 17,011,912 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	17,086,355 - 17,314,249 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	17,086,354 - 17,311,342 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	16,910,384 - 17,139,711 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	17,023,729 - 17,251,904 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	17,088,174 - 17,316,387 (+)	NCBI		UU_Cfam_GSD_1.0

Nek10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	185,197,612 - 185,410,520 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936473	18,342,329 - 18,534,353 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936473	18,341,867 - 18,548,966 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NEK10
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	13,752,467 - 13,930,483 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	13,751,178 - 13,931,896 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	15,303,339 - 15,476,157 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NEK10
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	71,687,799 - 71,938,573 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666041	44,867,548 - 45,128,407 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nek10
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624788	4,967,524 - 5,237,236 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624788	4,965,391 - 5,237,142 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Nek10
1589 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	61
Count of miRNA genes:	58
Interacting mature miRNAs:	60
Transcripts:	ENSRNOT00000007795, ENSRNOT00000030991
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354657	Despr13	Despair related QTL 13		0.0022	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	15	1	29912054	Rat
8552920	Pigfal8	Plasma insulin-like growth factor 1 level QTL 8	3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	15	1	34723002	Rat
8694361	Abfw6	Abdominal fat weight QTL 6	10.2	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	15	1	34723002	Rat
9589149	Insul29	Insulin level QTL 29	9.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	15	1	34723002	Rat
731170	Pur3	Proteinuria QTL 3	2.3	0.0005	urine protein amount (VT:0005160)	urine protein excretion rate (CMO:0000759)	15	1	41686771	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	42356671	Rat
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	306329	45306329	Rat
5684946	Bss98	Bone structure and strength QTL 98	3.9	0.0026	tibia strength trait (VT:1000284)	tibia ultimate force (CMO:0001734)	15	1058250	14481294	Rat
1641913	Colcr2	Colorectal carcinoma resistance QTL 2	6.57	0.0197	intestine integrity trait (VT:0010554)	colorectal tumor number (CMO:0001794)	15	2266368	22711984	Rat
1641913	Colcr2	Colorectal carcinoma resistance QTL 2	6.57	0.0197	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	15	2266368	22711984	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2266368	46921453	Rat
1582251	Gluco24	Glucose level QTL 24	3.2	0.0008	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	5530756	50530756	Rat

Markers in Region

RH140518

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	10,403,143 - 10,403,336 (+)	MAPPER	mRatBN7.2
mRatBN7.2	5	14,631,582 - 14,631,725 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	14,511,312 - 14,511,454	NCBI	Rnor6.0
Rnor_6.0	15	11,652,013 - 11,652,205	NCBI	Rnor6.0
Rnor_5.0	15	15,690,726 - 15,690,918	UniSTS	Rnor5.0
Rnor_5.0	5	19,293,611 - 19,293,753	UniSTS	Rnor5.0
RGSC_v3.4	5	14,834,174 - 14,834,316	UniSTS	RGSC3.4
RGSC_v3.4	15	11,881,548 - 11,881,740	UniSTS	RGSC3.4
Celera	15	10,413,518 - 10,413,710	UniSTS
Celera	5	14,002,802 - 14,002,944	UniSTS
Cytogenetic Map	5	q12	UniSTS
Cytogenetic Map	15	p16	UniSTS

RH132340

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	10,381,314 - 10,381,525 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	11,630,185 - 11,630,395	NCBI	Rnor6.0
Rnor_5.0	15	15,668,898 - 15,669,108	UniSTS	Rnor5.0
RGSC_v3.4	15	11,859,720 - 11,859,930	UniSTS	RGSC3.4
Celera	15	10,391,691 - 10,391,901	UniSTS
RH 3.4 Map	15	93.53	UniSTS
Cytogenetic Map	15	p16	UniSTS

RH141473

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	10,402,454 - 10,402,604 (+)	MAPPER	mRatBN7.2
mRatBN7.2	5	14,632,264 - 14,632,414 (-)	MAPPER	mRatBN7.2
mRatBN7.2	5	14,632,264 - 14,632,414 (+)	MAPPER	mRatBN7.2
mRatBN7.2	15	10,402,454 - 10,402,604 (-)	MAPPER	mRatBN7.2
Rnor_6.0	15	11,651,324 - 11,651,473	NCBI	Rnor6.0
Rnor_6.0	5	14,511,994 - 14,512,143	NCBI	Rnor6.0
Rnor_5.0	5	19,294,293 - 19,294,442	UniSTS	Rnor5.0
Rnor_5.0	15	15,690,037 - 15,690,186	UniSTS	Rnor5.0
RGSC_v3.4	5	14,834,856 - 14,835,005	UniSTS	RGSC3.4
RGSC_v3.4	15	11,880,859 - 11,881,008	UniSTS	RGSC3.4
Celera	15	10,412,829 - 10,412,978	UniSTS
Celera	5	14,003,484 - 14,003,633	UniSTS
Cytogenetic Map	15	p16	UniSTS
Cytogenetic Map	5	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium											3	1
Low		6	15		18		7	9	46	2	19	10	7
Below cutoff	3	19	15	14	1	14	1	2	22	30	14		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_006251721	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008767542	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008767545	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008770599	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599840	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093745	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACYVU010000260	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000007795 ⟹ ENSRNOP00000007795

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	10,381,140 - 10,559,722 (-)	Ensembl
Rnor_6.0 Ensembl	15	11,635,932 - 11,812,485 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000030991 ⟹ ENSRNOP00000031133

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	15	11,632,759 - 11,812,485 (-)	Ensembl

RefSeq Acc Id:

XM_039093745 ⟹ XP_038949673

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	10,387,063 - 10,564,177 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_038949673	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

ENSRNOP00000007795 ⟸ ENSRNOT00000007795

RefSeq Acc Id:

ENSRNOP00000031133 ⟸ ENSRNOT00000030991

RefSeq Acc Id:

XP_038949673 ⟸ XM_039093745

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZFA2-F1-model_v2	AlphaFold	D3ZFA2	1-1116	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564342	AgrOrtholog
BioCyc Gene	G2FUF-14401	BioCyc
Ensembl Genes	ENSRNOG00000005883	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000007795	ENTREZGENE
	ENSRNOP00000007795.8	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000007795	ENTREZGENE
	ENSRNOT00000007795.8	UniProtKB/TrEMBL
Gene3D-CATH	1.25.10.10	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	ARM-like	UniProtKB/TrEMBL
	ARM-type_fold	UniProtKB/TrEMBL
	Kinase-like_dom	UniProtKB/TrEMBL
	Nek10_STKc	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Tyr_prot_kinase_AS	UniProtKB/TrEMBL
NCBI Gene	305710	ENTREZGENE
PANTHER	SERINE/THREONINE-PROTEIN KINASE NEK	UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE NEK10	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
PhenoGen	Nek10	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
Superfamily-SCOP	ARM-type_fold	UniProtKB/TrEMBL
	Kinase_like	UniProtKB/TrEMBL
UniProt	D4A5Z9_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-11-21	Nek10	NIMA-related kinase 10	Nek10	NIMA (never in mitosis gene a)- related kinase 10	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-10-12	Nek10	NIMA (never in mitosis gene a)- related kinase 10	RGD1564342	similar to hypothetical protein FLJ32685	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1564342	similar to hypothetical protein FLJ32685	RGD1564342_predicted	similar to hypothetical protein FLJ32685 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1564342_predicted	similar to hypothetical protein FLJ32685 (predicted)	LOC305710	similar to hypothetical protein FLJ32685	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC305710	similar to hypothetical protein FLJ32685			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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