Dpy19l2 (dpy-19 like 2) - Rat Genome Database

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Gene: Dpy19l2 (dpy-19 like 2) Rattus norvegicus
Analyze
Symbol: Dpy19l2
Name: dpy-19 like 2
RGD ID: 1564311
Description: Predicted to enable mannosyltransferase activity. Predicted to be involved in spermatid development. Predicted to be active in nuclear inner membrane. Human ortholog(s) of this gene implicated in spermatogenic failure 9. Orthologous to several human genes including DPY19L2 (dpy-19 like 2); INTERACTS WITH bisphenol A; DDT; aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dpy-19-like 2; dpy-19-like 2 (C. elegans); Dyp19l2; LOC300461; probable C-mannosyltransferase DPY19L2; RGD1564311; similar to hypothetical protein FLJ32949
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8831,338,450 - 31,457,682 (-)NCBIGRCr8
mRatBN7.2823,062,592 - 23,181,817 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl823,063,115 - 23,181,798 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0825,710,492 - 25,829,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl825,710,472 - 25,829,569 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0825,741,576 - 25,859,681 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4824,203,761 - 24,329,745 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera824,639,030 - 24,755,540 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21397063   PMID:21397064   PMID:21630459   PMID:22764053  


Genomics

Comparative Map Data
Dpy19l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8831,338,450 - 31,457,682 (-)NCBIGRCr8
mRatBN7.2823,062,592 - 23,181,817 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl823,063,115 - 23,181,798 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0825,710,492 - 25,829,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl825,710,472 - 25,829,569 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0825,741,576 - 25,859,681 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4824,203,761 - 24,329,745 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera824,639,030 - 24,755,540 (-)NCBICelera
Cytogenetic Map8q13NCBI
DPY19L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381263,558,913 - 63,668,805 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1263,558,913 - 63,668,939 (-)EnsemblGRCh38hg38GRCh38
GRCh371263,952,693 - 64,062,273 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361262,238,960 - 62,348,621 (-)NCBINCBI36Build 36hg18NCBI36
Celera1263,620,809 - 63,730,544 (-)NCBICelera
Cytogenetic Map12q14.2NCBI
HuRef1261,003,714 - 61,113,278 (-)NCBIHuRef
CHM1_11263,920,378 - 64,029,984 (-)NCBICHM1_1
T2T-CHM13v2.01263,537,270 - 63,646,941 (-)NCBIT2T-CHM13v2.0
Dpy19l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39924,468,343 - 24,607,752 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl924,468,343 - 24,607,589 (-)EnsemblGRCm39 Ensembl
GRCm38924,557,047 - 24,696,457 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl924,557,047 - 24,696,293 (-)EnsemblGRCm38mm10GRCm38
MGSCv37924,361,492 - 24,500,737 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera921,814,343 - 21,953,569 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map910.22NCBI
DPY19L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21030,687,731 - 30,791,340 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11230,684,498 - 30,788,111 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01225,275,612 - 25,379,087 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1730,471,631 - 30,489,124 (+)NCBIpanpan1.1PanPan1.1panPan2
DPY19L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11446,785,528 - 46,880,959 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1446,787,335 - 46,881,053 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1446,229,027 - 46,322,706 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01446,727,356 - 46,821,482 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11446,834,905 - 46,928,855 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01446,511,614 - 46,605,352 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01446,885,239 - 46,979,447 (-)NCBIUU_Cfam_GSD_1.0
DPY19L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1838,694,257 - 38,765,941 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11838,693,951 - 38,765,943 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21842,524,666 - 42,597,130 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DPY19L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12123,259,906 - 23,346,210 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604281,609,110 - 81,688,473 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Dpy19l2
654 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:80
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000071884
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 2 2 23 12 11 2
Below cutoff 1 34 12 6 8 6 1 3 38 1 15 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000071884   ⟹   ENSRNOP00000067167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl823,063,115 - 23,181,798 (-)Ensembl
Rnor_6.0 Ensembl825,710,472 - 25,829,569 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105897   ⟹   ENSRNOP00000095091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl823,063,115 - 23,181,798 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111129   ⟹   ENSRNOP00000083270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl823,063,115 - 23,181,798 (-)Ensembl
RefSeq Acc Id: XM_006242722   ⟹   XP_006242784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8831,338,450 - 31,457,682 (-)NCBI
mRatBN7.2823,062,592 - 23,181,817 (-)NCBI
Rnor_6.0825,710,492 - 25,829,589 (-)NCBI
Rnor_5.0825,741,576 - 25,859,681 (-)NCBI
Sequence:
RefSeq Acc Id: XM_235972   ⟹   XP_235972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8831,338,450 - 31,457,682 (-)NCBI
mRatBN7.2823,062,592 - 23,181,817 (-)NCBI
Rnor_6.0825,710,492 - 25,829,589 (-)NCBI
Rnor_5.0825,741,576 - 25,859,681 (-)NCBI
RGSC_v3.4824,203,761 - 24,329,745 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_006242784 (Get FASTA)   NCBI Sequence Viewer  
  XP_235972 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83366 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067167
  ENSRNOP00000067167.2
  ENSRNOP00000083270
  ENSRNOP00000083270.1
  ENSRNOP00000095091.1
Reference Protein Sequences
RefSeq Acc Id: XP_235972   ⟸   XM_235972
- Peptide Label: isoform X2
- UniProtKB: M0RC58 (UniProtKB/TrEMBL),   A0A8I6AKU1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242784   ⟸   XM_006242722
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G8Q8 (UniProtKB/TrEMBL),   A0A8I6AKU1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067167   ⟸   ENSRNOT00000071884
RefSeq Acc Id: ENSRNOP00000095091   ⟸   ENSRNOT00000105897
RefSeq Acc Id: ENSRNOP00000083270   ⟸   ENSRNOT00000111129

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RC58-F1-model_v2 AlphaFold M0RC58 1-773 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695812
Promoter ID:EPDNEW_R6336
Type:initiation region
Name:Dpy19l2_1
Description:dpy-19 like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0825,829,559 - 25,829,619EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564311 AgrOrtholog
BioCyc Gene G2FUF-31346 BioCyc
Ensembl Genes ENSRNOG00000045585 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071884.3 UniProtKB/TrEMBL
  ENSRNOT00000105897.1 UniProtKB/TrEMBL
  ENSRNOT00000111129.1 UniProtKB/TrEMBL
InterPro Dpy-19 UniProtKB/TrEMBL
KEGG Report rno:300461 UniProtKB/TrEMBL
NCBI Gene 300461 ENTREZGENE
PANTHER PTHR31488 UniProtKB/TrEMBL
  PTHR31488:SF6 UniProtKB/TrEMBL
Pfam Dpy19 UniProtKB/TrEMBL
PhenoGen Dpy19l2 PhenoGen
RatGTEx ENSRNOG00000045585 RatGTEx
UniProt A0A8I6AKU1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G8Q8 ENTREZGENE, UniProtKB/TrEMBL
  M0RC58 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-20 Dpy19l2  dpy-19 like 2  Dpy19l2  dpy-19-like 2 (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-09 Dpy19l2  dpy-19-like 2 (C. elegans)  Dyp19l2  dpy-19-like 2 (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-05-25 Dyp19l2  dpy-19-like 2 (C. elegans)  RGD1564311  similar to hypothetical protein FLJ32949  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1564311  similar to hypothetical protein FLJ32949   RGD1564311_predicted  similar to hypothetical protein FLJ32949 (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 RGD1564311_predicted  similar to hypothetical protein FLJ32949 (predicted)  LOC678879  similar to dpy-19-like 1, like  Data merged from RGD:1595541 1643240 APPROVED
2006-11-20 LOC678879  similar to dpy-19-like 1, like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1564311_predicted  similar to hypothetical protein FLJ32949 (predicted)  LOC300461  similar to hypothetical protein FLJ32949  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC300461  similar to hypothetical protein FLJ32949      Symbol and Name status set to provisional 70820 PROVISIONAL