Zdhhc11 (zinc finger, DHHC-type containing 11) - Rat Genome Database

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Gene: Zdhhc11 (zinc finger, DHHC-type containing 11) Rattus norvegicus
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Symbol: Zdhhc11
Name: zinc finger, DHHC-type containing 11
RGD ID: 1564281
Description: Predicted to enable protein-cysteine S-palmitoyltransferase activity and signaling adaptor activity. Predicted to be involved in several processes, including antiviral innate immune response; peptidyl-L-cysteine S-palmitoylation; and positive regulation of defense response to virus by host. Predicted to be located in endosome membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC11 (zinc finger DHHC-type containing 11) and ZDHHC11B (zinc finger DHHC-type containing 11B); INTERACTS WITH bisphenol A; DDT; trichloroethene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DHHC-containing protein 10; LOC499000; membrane-associated DHHC11 zinc finger protein; probable palmitoyltransferase ZDHHC11; similar to DHHC-containing protein 10; Zdhhc20; zinc finger, DHHC domain containing 11; Znf399
RGD Orthologs
Human
Bonobo
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2129,296,216 - 29,327,227 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,296,334 - 29,326,898 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx129,097,732 - 29,128,405 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0135,097,587 - 35,128,260 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0129,298,346 - 29,329,029 (-)NCBIRnor_WKY
Rnor_6.0131,906,049 - 31,936,603 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl131,906,064 - 31,936,537 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0133,330,626 - 33,360,881 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4130,102,541 - 30,133,646 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera127,947,528 - 27,976,087 (-)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16647879   PMID:23687301   PMID:29429998  


Genomics

Comparative Map Data
Zdhhc11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2129,296,216 - 29,327,227 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,296,334 - 29,326,898 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx129,097,732 - 29,128,405 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0135,097,587 - 35,128,260 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0129,298,346 - 29,329,029 (-)NCBIRnor_WKY
Rnor_6.0131,906,049 - 31,936,603 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl131,906,064 - 31,936,537 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0133,330,626 - 33,360,881 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4130,102,541 - 30,133,646 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera127,947,528 - 27,976,087 (-)NCBICelera
Cytogenetic Map1p11NCBI
ZDHHC11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385795,605 - 860,563 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5795,605 - 858,973 (-)EnsemblGRCh38hg38GRCh38
GRCh375795,720 - 851,101 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365848,722 - 904,101 (-)NCBINCBI36Build 36hg18NCBI36
Build 345848,721 - 904,101NCBI
Celera54,577 - 11,091 (+)NCBICelera
Cytogenetic Map5p15.33NCBI
HuRef5779,861 - 833,985 (-)NCBIHuRef
CHM1_15795,441 - 850,829 (-)NCBICHM1_1
T2T-CHM13v2.05701,646 - 757,038 (-)NCBIT2T-CHM13v2.0
ZDHHC11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v05877,245 - 1,136,567 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3

Variants

.
Variants in Zdhhc11
202 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:106
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000060971
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5
Low 2 2
Below cutoff 1 6 3 3 2 3 1 1 62 5 22 5 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000060971   ⟹   ENSRNOP00000057691
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,296,334 - 29,326,898 (-)Ensembl
Rnor_6.0 Ensembl131,906,064 - 31,936,537 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117184   ⟹   ENSRNOP00000094386
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,306,042 - 29,326,200 (-)Ensembl
RefSeq Acc Id: NM_001039342   ⟹   NP_001034431
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2129,296,334 - 29,326,897 (-)NCBI
Rnor_6.0131,906,064 - 31,936,536 (-)NCBI
Rnor_5.0133,330,626 - 33,360,881 (-)NCBI
RGSC_v3.4130,102,541 - 30,133,646 (-)RGD
Celera127,947,528 - 27,976,087 (-)RGD
Sequence:
RefSeq Acc Id: XM_006227797   ⟹   XP_006227859
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2129,296,216 - 29,327,227 (-)NCBI
Rnor_6.0131,906,049 - 31,936,603 (-)NCBI
Rnor_5.0133,330,626 - 33,360,881 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086784   ⟹   XP_038942712
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2129,296,366 - 29,327,227 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001034431 (Get FASTA)   NCBI Sequence Viewer  
  XP_006227859 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942712 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAX73389 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001034431   ⟸   NM_001039342
- Sequence:
RefSeq Acc Id: XP_006227859   ⟸   XM_006227797
- Peptide Label: isoform X2
- UniProtKB: F1M6X9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000057691   ⟸   ENSRNOT00000060971
RefSeq Acc Id: XP_038942712   ⟸   XM_039086784
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000094386   ⟸   ENSRNOT00000117184
Protein Domains
DHHC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M6X9-F1-model_v2 AlphaFold F1M6X9 1-337 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689562
Promoter ID:EPDNEW_R86
Type:single initiation site
Name:Zdhhc11_1
Description:zinc finger, DHHC-type containing 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0131,936,571 - 31,936,631EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564281 AgrOrtholog
BioCyc Gene G2FUF-61936 BioCyc
Ensembl Genes ENSRNOG00000039743 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000057691 ENTREZGENE
  ENSRNOP00000057691.4 UniProtKB/TrEMBL
  ENSRNOP00000094386.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060971 ENTREZGENE
  ENSRNOT00000060971.4 UniProtKB/TrEMBL
  ENSRNOT00000117184.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7453233 IMAGE-MGC_LOAD
InterPro Znf_DHHC_palmitoyltrfase UniProtKB/TrEMBL
MGC_CLONE MGC:125090 IMAGE-MGC_LOAD
NCBI Gene 499000 ENTREZGENE
Pfam zf-DHHC UniProtKB/TrEMBL
PhenoGen Zdhhc11 PhenoGen
UniProt A0A8I6ALH7_RAT UniProtKB/TrEMBL
  F1M6X9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-12-15 Zdhhc11  zinc finger, DHHC-type containing 11  Zdhhc11  zinc finger, DHHC domain containing 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Zdhhc11  zinc finger, DHHC domain containing 11  LOC499000  similar to DHHC-containing protein 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC499000  similar to DHHC-containing protein 10      Symbol and Name status set to provisional 70820 PROVISIONAL