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Gene: Prrt2 (proline-rich transmembrane protein 2) Rattus norvegicus
Symbol: Prrt2
Name: proline-rich transmembrane protein 2
Description: Exhibits SH3 domain binding activity. Predicted to be involved in several processes, including negative regulation of SNARE complex assembly; negative regulation of short-term synaptic potentiation; and synaptic vesicle exocytosis. Localizes to neuron projection. Human ortholog(s) of this gene implicated in benign familial neonatal epilepsy and episodic kinesigenic dyskinesia 1. Orthologous to human PRRT2 (proline rich transmembrane protein 2); INTERACTS WITH 6-propyl-2-thiouracil; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Dispanin subfamily B member 3; DSPB3; LOC361651; RGD1564195; similar to hypothetical protein
Homo sapiens (human) : PRRT2 (proline rich transmembrane protein 2)  HGNC  Alliance
Mus musculus (house mouse) : Prrt2 (proline-rich transmembrane protein 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prrt2 (proline rich transmembrane protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PRRT2 (proline rich transmembrane protein 2)
Canis lupus familiaris (dog) : PRRT2 (proline rich transmembrane protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prrt2 (proline rich transmembrane protein 2)
Sus scrofa (pig) : PRRT2 (proline rich transmembrane protein 2)
Chlorocebus sabaeus (African green monkey) : PRRT2 (proline rich transmembrane protein 2)
Heterocephalus glaber (naked mole-rat) : Prrt2 (proline rich transmembrane protein 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01198,451,042 - 198,454,998 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,451,324 - 198,454,914 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,431,478 - 205,435,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,196,585 - 186,199,258 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1179,279,909 - 179,283,499 (-)NCBICelera
Cytogenetic Map1q37NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Prrt2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1564195
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.