Npsr1 (neuropeptide S receptor 1) - Rat Genome Database

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Gene: Npsr1 (neuropeptide S receptor 1) Rattus norvegicus
Symbol: Npsr1
Name: neuropeptide S receptor 1
RGD ID: 1564154
Description: Predicted to enable neuropeptide receptor activity. Involved in several processes, including negative regulation of defecation; positive regulation of ERK1 and ERK2 cascade; and righting reflex. Predicted to be active in cytoplasm and plasma membrane. Biomarker of morphine dependence. Human ortholog(s) of this gene implicated in asthma; inflammatory bowel disease; newborn respiratory distress syndrome; and rheumatoid arthritis. Orthologous to human NPSR1 (neuropeptide S receptor 1); INTERACTS WITH acrylamide; bisphenol A; bromobenzene.
Type: protein-coding
Previously known as: G-protein coupled receptor 154; LOC300458; neuropeptide S receptor; RGD1564154; similar to G protein-coupled receptor 154
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2822,606,946 - 22,831,558 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl822,606,946 - 22,831,558 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx826,641,001 - 26,865,608 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0824,938,241 - 25,162,852 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0822,837,781 - 23,062,363 (+)NCBIRnor_WKY
Rnor_6.0825,246,174 - 25,483,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl825,246,292 - 25,482,647 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0825,328,131 - 25,514,199 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4823,736,081 - 23,970,242 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera824,184,221 - 24,410,253 (+)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cellular_component  (ND)
cytoplasm  (IBA,ISO)
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Function


References - curated
# Reference Title Reference Citation
1. The protective effect of farm animal exposure on childhood allergy is modified by NPSR1 polymorphisms. Bruce S, etal., J Med Genet. 2009 Mar;46(3):159-67. Epub 2008 Feb 19.
2. Effect of neuropeptide S receptor antagonists and partial agonists on palatable food consumption in the rat. Cifani C, etal., Peptides. 2011 Jan;32(1):44-50. doi: 10.1016/j.peptides.2010.10.018. Epub 2010 Oct 29.
3. Neuropeptide s receptor 1 gene polymorphism is associated with susceptibility to inflammatory bowel disease. D'Amato M, etal., Gastroenterology. 2007 Sep;133(3):808-17. Epub 2007 Jun 20.
4. Analysis of neuropeptide S receptor gene (NPSR1) polymorphism in rheumatoid arthritis. D'Amato M, etal., PLoS One. 2010 Feb 22;5(2):e9315.
5. The paraventricular nucleus of the hypothalamus is a neuroanatomical substrate for the inhibition of palatable food intake by neuropeptide S. Fedeli A, etal., Eur J Neurosci. 2009 Oct;30(8):1594-602. doi: 10.1111/j.1460-9568.2009.06948.x. Epub 2009 Oct 12.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Morphine dependence is associated with changes in neuropeptide S receptor expression and function in rat brain. Ghazal P, etal., Peptides. 2013 Aug;46:6-12. doi: 10.1016/j.peptides.2013.05.001. Epub 2013 May 16.
8. Comprehensive testing of positionally cloned asthma genes in two populations. Hersh CP, etal., Am J Respir Crit Care Med. 2007 Nov 1;176(9):849-57. Epub 2007 Aug 16.
9. The effects of neuropeptide S on general anesthesia in rats. Kushikata T, etal., Anesth Analg. 2011 Apr;112(4):845-9. doi: 10.1213/ANE.0b013e31820b990d. Epub 2011 Feb 2.
10. Characterization of a common susceptibility locus for asthma-related traits. Laitinen T, etal., Science. 2004 Apr 9;304(5668):300-4.
11. Nasal application of neuropeptide S inhibits arthritis pain-related behaviors through an action in the amygdala. Medina G, etal., Mol Pain. 2014 May 29;10:32. doi: 10.1186/1744-8069-10-32.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Neuropeptide S inhibits stress-stimulated faecal output in the rat. Petrella C, etal., Pharmacol Res. 2011 Nov;64(5):471-7. doi: 10.1016/j.phrs.2011.06.007. Epub 2011 Jun 17.
14. G protein-coupled receptor for asthma susceptibility associates with respiratory distress syndrome. Pulkkinen V, etal., Ann Med. 2006;38(5):357-66.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Neuropeptide S receptor gene expression in alcohol withdrawal and protracted abstinence in postdependent rats. Ruggeri B, etal., Alcohol Clin Exp Res. 2010 Jan;34(1):90-7. doi: 10.1111/j.1530-0277.2009.01070.x. Epub 2009 Oct 23.
20. Antagonism of the neuropeptide S receptor with RTI-118 decreases cocaine self-administration and cocaine-seeking behavior in rats. Schmoutz CD, etal., Pharmacol Biochem Behav. 2012 Dec;103(2):332-7. doi: 10.1016/j.pbb.2012.09.003. Epub 2012 Sep 12.
21. A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. Thorsell A, etal., J Neurosci. 2013 Jun 12;33(24):10132-42. doi: 10.1523/JNEUROSCI.4742-12.2013.
Additional References at PubMed
PMID:15057822   PMID:15947423   PMID:16790440   PMID:17645946   PMID:20950671   PMID:24978951   PMID:26227793   PMID:29157796   PMID:32044336  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2822,606,946 - 22,831,558 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl822,606,946 - 22,831,558 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx826,641,001 - 26,865,608 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0824,938,241 - 25,162,852 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0822,837,781 - 23,062,363 (+)NCBIRnor_WKY
Rnor_6.0825,246,174 - 25,483,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl825,246,292 - 25,482,647 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0825,328,131 - 25,514,199 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4823,736,081 - 23,970,242 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera824,184,221 - 24,410,253 (+)NCBICelera
Cytogenetic Map8q13NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38734,658,218 - 34,878,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl734,658,218 - 34,878,332 (+)EnsemblGRCh38hg38GRCh38
GRCh37734,697,830 - 34,917,944 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36734,664,422 - 34,884,469 (+)NCBINCBI36Build 36hg18NCBI36
Build 34734,471,136 - 34,691,184NCBI
Celera734,678,763 - 34,899,690 (+)NCBICelera
Cytogenetic Map7p14.3NCBI
HuRef734,579,047 - 34,799,739 (+)NCBIHuRef
CHM1_1734,697,921 - 34,917,510 (+)NCBICHM1_1
T2T-CHM13v2.0734,798,021 - 35,019,005 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2734,742,034 - 34,962,952 (+)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39924,009,212 - 24,229,151 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl924,009,292 - 24,227,694 (+)EnsemblGRCm39 Ensembl
GRCm38924,097,912 - 24,317,590 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl924,097,996 - 24,316,398 (+)EnsemblGRCm38mm10GRCm38
MGSCv37923,902,462 - 24,120,842 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36923,848,425 - 24,066,805 (+)NCBIMGSCv36mm8
Celera921,355,713 - 21,573,552 (+)NCBICelera
Cytogenetic Map9A3- A4NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049555601,069,651 - 1,243,111 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555601,069,651 - 1,243,111 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1735,663,335 - 35,883,988 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl735,663,335 - 35,883,988 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0735,274,102 - 35,494,389 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11446,465,169 - 46,610,256 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1446,466,544 - 46,609,477 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1445,908,550 - 46,051,177 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01446,406,554 - 46,549,450 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1446,406,661 - 46,549,459 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11446,514,493 - 46,657,229 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01446,191,033 - 46,333,686 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01446,564,692 - 46,707,288 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440511891,141,108 - 91,331,221 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647810,352,741 - 10,544,102 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647810,352,894 - 10,542,949 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1838,942,487 - 39,085,754 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11838,942,499 - 39,212,791 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21842,772,920 - 42,892,071 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12123,558,313 - 23,784,475 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604279,478,183 - 79,684,440 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Variants in Npsr1
1516 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:677
Count of miRNA genes:291
Interacting mature miRNAs:370
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Low 2 23 3
Below cutoff 2 10 20 7 13 7 2 2 27 18 32 10 2


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021625   ⟹   ENSRNOP00000021625
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl822,606,946 - 22,831,558 (+)Ensembl
Rnor_6.0 Ensembl825,246,292 - 25,482,647 (+)Ensembl
RefSeq Acc Id: NM_001106808   ⟹   NP_001100278
Rat AssemblyChrPosition (strand)Source
mRatBN7.2822,606,946 - 22,831,558 (+)NCBI
Rnor_6.0825,246,292 - 25,482,647 (+)NCBI
Rnor_5.0825,328,131 - 25,514,199 (+)NCBI
RGSC_v3.4823,736,081 - 23,970,242 (+)RGD
Celera824,184,221 - 24,410,253 (+)RGD
Protein Sequences
Protein RefSeqs NP_001100278 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83371 (Get FASTA)   NCBI Sequence Viewer  
  EDL83372 (Get FASTA)   NCBI Sequence Viewer  
  P0C0L6 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100278   ⟸   NM_001106808
- UniProtKB: A0A0H2UHN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021625   ⟸   ENSRNOT00000021625
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C0L6-F1-model_v2 AlphaFold P0C0L6 1-372 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564154 AgrOrtholog
BioCyc Gene G2FUF-31350 BioCyc
Ensembl Genes ENSRNOG00000015863 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000021625 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021625 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPS_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vasoprsn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:300458 UniProtKB/TrEMBL
PANTHER PTHR24244:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Npsr1 PhenoGen
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Npsr1  neuropeptide S receptor 1  RGD1564154_predicted  similar to G protein-coupled receptor 154 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564154_predicted  similar to G protein-coupled receptor 154 (predicted)  LOC300458  similar to G protein-coupled receptor 154  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC300458  similar to G protein-coupled receptor 154      Symbol and Name status set to provisional 70820 PROVISIONAL