Prknl1 (parkin RBR E3 ubiquitin protein ligase like 1) - Rat Genome Database

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Gene: Prknl1 (parkin RBR E3 ubiquitin protein ligase like 1) Rattus norvegicus
Analyze
Symbol: Prknl1
Name: parkin RBR E3 ubiquitin protein ligase like 1
RGD ID: 1564133
Description: ENCODES a protein that exhibits small molecule binding (inferred); FOUND IN extracellular space (inferred); INTERACTS WITH bisphenol A
Type: protein-coding
RefSeq Status: MODEL
Previously known as: lipocalin-1-like; LOC103690145; LOC502612; odorant-binding protein 2a-like; RGD1564133; similar to odorant binding protein 2B; uncharacterized LOC103690145
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,965,802 - 28,972,738 (+)NCBIGRCr8
mRatBN7.238,571,021 - 8,574,555 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.032,990,757 - 2,994,002 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.032,970,815 - 2,974,019 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,923,899 - 3,927,279 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Prknl1
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:93
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000071907
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_063284812   ⟹   XP_063140882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,969,928 - 28,972,738 (+)NCBI
RefSeq Acc Id: XM_063284813   ⟹   XP_063140883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,965,802 - 28,972,738 (+)NCBI
Protein Sequences
Protein RefSeqs XP_063140882 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140883 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074582.2
Reference Protein Sequences
RefSeq Acc Id: XP_063140883   ⟸   XM_063284813
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K8F0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140882   ⟸   XM_063284812
- Peptide Label: isoform X1
Protein Domains
Lipocalin/cytosolic fatty-acid binding

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-50417 BioCyc
Ensembl Genes ENSRNOG00000067005 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080402.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.128.20 UniProtKB/TrEMBL
InterPro Calycin UniProtKB/TrEMBL
  Lipocalin UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/TrEMBL
  von_Ebner_gland UniProtKB/TrEMBL
NCBI Gene 502612 ENTREZGENE
PANTHER LIPOCALIN UniProtKB/TrEMBL
  ODORANT-BINDING PROTEIN 2A-RELATED UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/TrEMBL
PhenoGen Prknl1 PhenoGen
PRINTS VNEBNERGLAND UniProtKB/TrEMBL
Superfamily-SCOP Lipocalins UniProtKB/TrEMBL
UniProt A0A0G2K8F0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Prknl1  parkin RBR E3 ubiquitin protein ligase like 1  RGD1564133  similar to odorant binding protein 2B  Symbol and Name Changed 1299863 APPROVED
2021-03-09 RGD1564133  similar to odorant binding protein 2B  LOC103690145  uncharacterized LOC103690145  Data merged from RGD:9137231 737654 PROVISIONAL
2014-08-25 LOC103690145  uncharacterized LOC103690145      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1564133  similar to odorant binding protein 2B   RGD1564133_predicted  similar to odorant binding protein 2B (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564133_predicted  similar to odorant binding protein 2B (predicted)  LOC502612  similar to odorant binding protein 2B  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC502612  similar to odorant binding protein 2B      Symbol and Name status set to provisional 70820 PROVISIONAL