Vit (vitrin) - Rat Genome Database

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Gene: Vit (vitrin) Rattus norvegicus
Analyze
Symbol: Vit
Name: vitrin
RGD ID: 1564128
Description: Predicted to enable glycosaminoglycan binding activity. Predicted to be involved in extracellular matrix organization; positive regulation of cell-substrate adhesion; and spinal cord development. Predicted to be located in extracellular matrix. Predicted to be active in interstitial matrix. Orthologous to human VIT (vitrin); INTERACTS WITH bisphenol A; cadmium dichloride; Cuprizon.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC313831; RGD1564128; similar to vitrin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8622,198,095 - 22,317,758 (-)NCBIGRCr8
mRatBN7.2616,445,966 - 16,565,644 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl616,445,955 - 16,565,665 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.061,091,817 - 1,208,888 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl61,147,012 - 1,208,392 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.061,083,150 - 1,199,622 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.461,319,479 - 1,399,647 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera616,094,236 - 16,211,803 (-)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18757743   PMID:25331329  


Genomics

Comparative Map Data
Vit
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8622,198,095 - 22,317,758 (-)NCBIGRCr8
mRatBN7.2616,445,966 - 16,565,644 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl616,445,955 - 16,565,665 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.061,091,817 - 1,208,888 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl61,147,012 - 1,208,392 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.061,083,150 - 1,199,622 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.461,319,479 - 1,399,647 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera616,094,236 - 16,211,803 (-)NCBICelera
Cytogenetic Map6q12NCBI
VIT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38236,696,707 - 36,814,794 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl236,696,690 - 36,814,794 (+)EnsemblGRCh38hg38GRCh38
GRCh37236,923,850 - 37,041,937 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36236,777,418 - 36,895,433 (+)NCBINCBI36Build 36hg18NCBI36
Build 34236,835,564 - 36,953,580NCBI
Celera236,764,899 - 36,882,980 (+)NCBICelera
Cytogenetic Map2p22.2NCBI
HuRef236,664,350 - 36,808,557 (+)NCBIHuRef
CHM1_1236,853,402 - 36,971,176 (+)NCBICHM1_1
T2T-CHM13v2.0236,703,628 - 36,821,971 (+)NCBIT2T-CHM13v2.0
Vit
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391778,815,480 - 78,934,838 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1778,815,493 - 78,934,837 (+)EnsemblGRCm39 Ensembl
GRCm381778,508,051 - 78,627,409 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1778,508,064 - 78,627,408 (+)EnsemblGRCm38mm10GRCm38
MGSCv371778,907,480 - 79,026,738 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361778,413,198 - 78,532,456 (+)NCBIMGSCv36mm8
Celera1782,812,373 - 82,934,688 (+)NCBICelera
Cytogenetic Map17E3NCBI
cM Map1749.38NCBI
Vit
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554414,546,984 - 4,649,962 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554414,527,281 - 4,650,384 (+)NCBIChiLan1.0ChiLan1.0
VIT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21289,665,711 - 89,780,489 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A89,669,694 - 89,784,465 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A36,726,717 - 36,841,491 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A37,490,294 - 37,604,177 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A37,490,294 - 37,604,177 (+)Ensemblpanpan1.1panPan2
VIT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11729,142,924 - 29,259,800 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1729,143,069 - 29,243,406 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1728,956,626 - 29,062,499 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01729,793,055 - 29,897,704 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1729,793,067 - 29,899,491 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11729,021,084 - 29,125,612 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01729,082,651 - 29,187,237 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01729,301,977 - 29,406,620 (+)NCBIUU_Cfam_GSD_1.0
Vit
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629242,737,221 - 42,842,844 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366631,403,128 - 1,484,353 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366631,402,713 - 1,508,253 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VIT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3103,377,575 - 103,492,985 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13103,379,127 - 103,492,989 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23109,958,866 - 110,020,029 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VIT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11470,593,305 - 70,725,537 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1470,593,739 - 70,688,664 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604541,232,217 - 41,360,522 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vit
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473818,358,372 - 18,447,689 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473818,339,587 - 18,448,639 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Vit
856 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:48
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000006360
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
8693699Alc37Alcohol consumption QTL 372.60.224drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)6796416721301982Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6507449719988050Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6984331220338915Rat
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6984331220338915Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)61653614027261739Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
8693690Alc35Alcohol consumption QTL 352.20.606drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)6796416721301982Rat

Markers in Region
D6Rat40  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2616,536,243 - 16,536,392 (-)MAPPERmRatBN7.2
Rnor_6.061,120,393 - 1,120,541NCBIRnor6.0
Rnor_5.061,111,498 - 1,111,646UniSTSRnor5.0
RGSC_v3.461,301,953 - 1,302,101UniSTSRGSC3.4
RGSC_v3.461,301,952 - 1,302,101RGDRGSC3.4
RGSC_v3.161,301,953 - 1,302,101RGD
Celera616,183,650 - 16,183,798UniSTS
RH 3.4 Map629.0UniSTS
RH 3.4 Map629.0RGD
RH 2.0 Map6124.4RGD
SHRSP x BN Map618.3798RGD
Cytogenetic Map6q11UniSTS
D6Rat80  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2616,536,140 - 16,536,392 (-)MAPPERmRatBN7.2
Rnor_6.061,120,393 - 1,120,644NCBIRnor6.0
Rnor_5.061,111,498 - 1,111,749UniSTSRnor5.0
RGSC_v3.461,301,952 - 1,302,204RGDRGSC3.4
RGSC_v3.461,301,953 - 1,302,204UniSTSRGSC3.4
RGSC_v3.161,301,953 - 1,302,204RGD
Celera616,183,547 - 16,183,798UniSTS
RH 3.4 Map623.9UniSTS
RH 3.4 Map623.9RGD
RH 2.0 Map6122.3RGD
SHRSP x BN Map618.3999RGD
Cytogenetic Map6q11UniSTS
Cytogenetic Map6q14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 28 113 35 34 4 19 4 6 121 70 93 30 54 30

Sequence


Ensembl Acc Id: ENSRNOT00000006360   ⟹   ENSRNOP00000006360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl616,445,955 - 16,541,126 (-)Ensembl
Rnor_6.0 Ensembl61,147,012 - 1,208,392 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098785   ⟹   ENSRNOP00000081700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl616,445,955 - 16,565,665 (-)Ensembl
RefSeq Acc Id: XM_008764427   ⟹   XP_008762649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8622,198,095 - 22,317,758 (-)NCBI
mRatBN7.2616,445,966 - 16,565,644 (-)NCBI
Rnor_6.061,091,817 - 1,208,888 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039113076   ⟹   XP_038969004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8622,198,095 - 22,230,912 (-)NCBI
mRatBN7.2616,445,966 - 16,478,754 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001418816 (Get FASTA)   NCBI Sequence Viewer  
  XP_008762649 (Get FASTA)   NCBI Sequence Viewer  
  XP_038969004 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM02817 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006360.8
  ENSRNOP00000081700.1
RefSeq Acc Id: XP_008762649   ⟸   XM_008764427
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000006360   ⟸   ENSRNOT00000006360
RefSeq Acc Id: XP_038969004   ⟸   XM_039113076
- Peptide Label: isoform X2
- UniProtKB: A6H9W2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081700   ⟸   ENSRNOT00000098785
Protein Domains
LCCL   VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M095-F1-model_v2 AlphaFold F1M095 1-616 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564128 AgrOrtholog
BioCyc Gene G2FUF-38484 BioCyc
Ensembl Genes ENSRNOG00000004706 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006360.8 UniProtKB/TrEMBL
  ENSRNOT00000098785.1 UniProtKB/TrEMBL
Gene3D-CATH 2.170.130.20 UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/TrEMBL
InterPro ECM_Assembly_Org UniProtKB/TrEMBL
  LCCL UniProtKB/TrEMBL
  LCCL_sf UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
KEGG Report rno:313831 UniProtKB/TrEMBL
NCBI Gene 313831 ENTREZGENE
PANTHER COLLAGEN ALPHA UniProtKB/TrEMBL
  VITRIN UniProtKB/TrEMBL
Pfam LCCL UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
PhenoGen Vit PhenoGen
PRINTS VWFADOMAIN UniProtKB/TrEMBL
PROSITE LCCL UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004706 RatGTEx
SMART LCCL UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP LCCL UniProtKB/TrEMBL
  SSF53300 UniProtKB/TrEMBL
UniProt A0A8I5ZT33 ENTREZGENE, UniProtKB/TrEMBL
  A6H9W2 ENTREZGENE, UniProtKB/TrEMBL
  F1M095_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Vit  vitrin  RGD1564128_predicted  similar to vitrin (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564128_predicted  similar to vitrin (predicted)  LOC313831  similar to vitrin  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC313831  similar to vitrin      Symbol and Name status set to provisional 70820 PROVISIONAL